PDB: 1556 件ウェブページステータス検索Chemie searchBIRD

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1FQM	X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT 分子名称: CARBONIC ANHYDRASE, MERCURY (II) ION, ZINC ION 著者 Cox, J.D, Hunt, J.A, Compher, K.M, Fierke, C.A, Christianson, D.W. 登録日 2000-09-06 公開日 2001-01-17 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II. Biochemistry, 39, 2000
4MO8	The crystal structure of the human carbonic anhydrase II in complex with N-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]sulfamide 分子名称: Carbonic anhydrase 2, N-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]sulfamide, ZINC ION 著者 Alterio, V, De Simone, G. 登録日 2013-09-11 公開日 2013-10-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Hypoxia-Targeting Carbonic Anhydrase IX Inhibitors by a New Series of Nitroimidazole-Sulfonamides/Sulfamides/Sulfamates. J.Med.Chem., 56, 2013
6SDT	HUMAN CARBONIC ANHYDRASE VII IN COMPLEX WITH A SULFONAMIDE INHIBITOR 分子名称: Carbonic anhydrase 7, ZINC ION, phenyl-(4-sulfamoylphenoxy)phosphinic acid 著者 Alterio, V, De Simone, G, Esposito, D. 登録日 2019-07-29 公開日 2020-06-10 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Phenyl(thio)phosphon(amid)ate Benzenesulfonamides as Potent and Selective Inhibitors of Human Carbonic Anhydrases II and VII Counteract Allodynia in a Mouse Model of Oxaliplatin-Induced Neuropathy. J.Med.Chem., 63, 2020
3MNK	Human Carbonic Anhydrase II Mutant K170H 分子名称: Carbonic anhydrase 2, SODIUM ION, ZINC ION 著者 Domsic, J.F, McKenna, R. 登録日 2010-04-21 公開日 2010-07-14 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structural and kinetic study of the extended active site for proton transfer in human carbonic anhydrase II. Biochemistry, 49, 2010
4QEF	Human Carbonic Anhydrase II V207I - cyanate inhibitor complex 分子名称: Carbonic anhydrase 2, GLYCEROL, ZINC ION, ... 著者 West, D.M. 登録日 2014-05-15 公開日 2014-10-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.469 Å) 主引用文献 Human carbonic anhydrase II-cyanate inhibitor complex: putting the debate to rest. Acta Crystallogr F Struct Biol Commun, 70, 2014
1FQL	X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT 分子名称: CARBONIC ANHYDRASE, MERCURY (II) ION, ZINC ION 著者 Cox, J.D, Hunt, J.A, Compher, K.M, Fierke, C.A, Christianson, D.W. 登録日 2000-09-05 公開日 2001-01-17 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II. Biochemistry, 39, 2000
3MNH	Human Carbonic Anhydrase II Mutant K170A 分子名称: Carbonic anhydrase 2, SODIUM ION, ZINC ION 著者 Domsic, J.F, McKenna, R. 登録日 2010-04-21 公開日 2010-07-14 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structural and kinetic study of the extended active site for proton transfer in human carbonic anhydrase II. Biochemistry, 49, 2010
1BCD	X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A COMPLEX BETWEEN HUMAN CARBONIC ANHYDRASE II AND A NEW TOPICAL INHIBITOR, TRIFLUOROMETHANE SULPHONAMIDE 分子名称: CARBONIC ANHYDRASE II, TRIFLUOROMETHANE SULFONAMIDE, ZINC ION 著者 Hakansson, K, Liljas, A. 登録日 1993-08-31 公開日 1993-10-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The structure of a complex between carbonic anhydrase II and a new inhibitor, trifluoromethane sulphonamide. FEBS Lett., 350, 1994
3MNI	Human Carbonic Anhydrase II Mutant K170D 分子名称: Carbonic anhydrase 2, SODIUM ION, ZINC ION 著者 Domsic, J.F, McKenna, R. 登録日 2010-04-21 公開日 2010-07-14 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structural and kinetic study of the extended active site for proton transfer in human carbonic anhydrase II. Biochemistry, 49, 2010
3MNJ	Human Carbonic Anhydrase II Mutant K170E 分子名称: Carbonic anhydrase 2, SODIUM ION, ZINC ION 著者 Domsic, J.F, McKenna, R. 登録日 2010-04-21 公開日 2010-07-14 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structural and kinetic study of the extended active site for proton transfer in human carbonic anhydrase II. Biochemistry, 49, 2010
3TMJ	Joint X-ray/neutron structure of human carbonic anhydrase II at pH 7.8 分子名称: Carbonic anhydrase 2, ZINC ION 著者 Fisher, Z. 登録日 2011-08-31 公開日 2011-11-09 最終更新日 2023-09-13 実験手法 NEUTRON DIFFRACTION (2 Å), X-RAY DIFFRACTION 主引用文献 Neutron Structure of Human Carbonic Anhydrase II: A Hydrogen-Bonded Water Network "Switch" Is Observed between pH 7.8 and 10.0. Biochemistry, 50, 2011
1G0F	SITE-SPECIFIC MUTANT (HIS64 REPLACED WITH ALA) OF HUMAN CARBONIC ANHYDRASE II 分子名称: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION 著者 Duda, D, McKenna, R. 登録日 2000-10-06 公開日 2000-10-18 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural and kinetic analysis of the chemical rescue of the proton transfer function of carbonic anhydrase II. Biochemistry, 40, 2001
3V7X	Complex of human carbonic anhydrase II with N-[2-(3,4-dimethoxyphenyl)ethyl]-4-sulfamoylbenzamide 分子名称: Carbonic anhydrase 2, GLYCEROL, MERCURIBENZOIC ACID, ... 著者 Mader, P, Brynda, J, Rezacova, P. 登録日 2011-12-22 公開日 2012-04-04 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.03 Å) 主引用文献 Synthesis, Structure-Activity Relationship Studies, and X-ray Crystallographic Analysis of Arylsulfonamides as Potent Carbonic Anhydrase Inhibitors. J.Med.Chem., 55, 2012
3KNE	Carbonic Anhydrase II H64C mutant in complex with an in situ formed triazole 分子名称: (4-CARBOXYPHENYL)(CHLORO)MERCURY, Carbonic anhydrase 2, N-[(S)-(1-{2-oxo-2-[(3-sulfanylpropyl)amino]ethyl}-1H-1,2,3-triazol-5-yl)(phenyl)methyl]-4-sulfamoylbenzamide, ... 著者 Schulze-Wischeler, J, Heine, A, Klebe, G. 登録日 2009-11-12 公開日 2011-05-18 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Stereo- and Regioselective Azide/Alkyne Cycloadditions in Carbonic Anhydrase II via Tethering, Monitored by Crystallography and Mass Spectrometry. Chemistry, 17, 2011
1FLJ	CRYSTAL STRUCTURE OF S-GLUTATHIOLATED CARBONIC ANHYDRASE III 分子名称: CARBONIC ANHYDRASE III, GLUTATHIONE, ZINC ION 著者 Mallis, R.J, Poland, B.W, Chatterjee, T.K, Fisher, R.A, Darmawan, S, Honzatko, R.B, Thomas, J.A. 登録日 2000-08-14 公開日 2000-09-04 最終更新日 2017-10-04 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of S-glutathiolated carbonic anhydrase III. FEBS Lett., 482, 2000
4LU3	The crystal structure of the human carbonic anhydrase XIV 分子名称: 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, Carbonic anhydrase 14, GLYCEROL, ... 著者 Alterio, V, De Simone, G, Monti, S.M. 登録日 2013-07-24 公開日 2014-01-01 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The structural comparison between membrane-associated human carbonic anhydrases provides insights into drug design of selective inhibitors. Biopolymers, 101, 2014
3KS3	High resolution structure of Human Carbonic Anhydrase II at 0.9 A 分子名称: Carbonic anhydrase 2, GLYCEROL, ZINC ION 著者 Avvaru, B.S. 登録日 2009-11-20 公開日 2010-01-26 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (0.9 Å) 主引用文献 A short, strong hydrogen bond in the active site of human carbonic anhydrase II. Biochemistry, 49, 2010
3MWO	Human carbonic anhydrase II in a doubled monoclinic cell: a re-determination 分子名称: Carbonic anhydrase 2, ZINC ION 著者 Robbins, A.H, McKenna, R. 登録日 2010-05-06 公開日 2010-06-09 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Emerging from pseudo-symmetry: the redetermination of human carbonic anhydrase II in monoclinic P2(1) with a doubled a axis. Acta Crystallogr.,Sect.D, 66, 2010
1A42	HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH BRINZOLAMIDE 分子名称: (4R)-2-(2-ethoxyethyl)-4-(ethylamino)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide, CARBONIC ANHYDRASE II, MERCURY (II) ION, ... 著者 Boriack-Sjodin, P.A, Christianson, D.W. 登録日 1998-02-10 公開日 1999-03-23 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination. Protein Sci., 7, 1998
3M5S	Carbonic Anhydrase II mutant H64C in complex with carbonate 分子名称: CARBONATE ION, Carbonic anhydrase 2, ZINC ION 著者 Schulze Wischeler, J, Heine, A, Klebe, G. 登録日 2010-03-13 公開日 2011-05-25 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Mutational study on Carbonic Anhydrase II TO BE PUBLISHED
3KKX	Neutron structure of human carbonic anhydrase II 分子名称: Carbonic anhydrase 2, ZINC ION 著者 Fisher, S.Z, Langan, P.A. 登録日 2009-11-06 公開日 2010-01-12 最終更新日 2023-09-06 実験手法 NEUTRON DIFFRACTION (2 Å) 主引用文献 Neutron structure of human carbonic anhydrase II: implications for proton transfer. Biochemistry, 49, 2010
1HEB	STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II 分子名称: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION 著者 Nair, S.K, Christianson, D.W. 登録日 1992-07-16 公開日 1992-10-15 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural consequences of hydrophilic amino acid substitutions in the hydrophobic pocket of human carbonic anhydrase II. Biochemistry, 32, 1993
1HEC	STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II 分子名称: CARBONIC ANHYDRASE II, ZINC ION 著者 Nair, S.K, Christianson, D.W. 登録日 1992-07-16 公開日 1992-10-15 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural consequences of hydrophilic amino acid substitutions in the hydrophobic pocket of human carbonic anhydrase II. Biochemistry, 32, 1993
1HED	STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II 分子名称: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION 著者 Nair, S.K, Christianson, D.W. 登録日 1992-07-16 公開日 1992-10-15 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural consequences of hydrophilic amino acid substitutions in the hydrophobic pocket of human carbonic anhydrase II. Biochemistry, 32, 1993
3MNA	The crystal structure of human carbonic anhydrase Ii in complex with a 1,3,5-triazine-substituted benzenesulfonamide inhibitor 分子名称: Carbonic anhydrase 2, GLYCEROL, ZINC ION, ... 著者 Avvaru, B.S, Wagner, J, Robbins, A.H, Mckenna, R. 登録日 2010-04-21 公開日 2011-04-20 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies. Bioorg.Med.Chem., 19, 2011

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