8DGY
| Structure of MERS 3CL protease in complex with the cyclopropane based inhibitor 16d (high resolution) | 分子名称: | 3C-like proteinase, [(1~{R},2~{R})-2-(cyclohexylmethyl)cyclopropyl]methyl ~{N}-[(2~{S})-1-[[(1~{R},2~{S})-1-[bis(oxidanyl)-oxidanylidene-$l^{5}-sulfanyl]-1-oxidanyl-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]carbamate, [(1~{R},2~{R})-2-(cyclohexylmethyl)cyclopropyl]methyl ~{N}-[(2~{S})-1-[[(1~{S},2~{S})-1-[bis(oxidanyl)-oxidanylidene-$l^{5}-sulfanyl]-1-oxidanyl-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]carbamate | 著者 | Lovell, S, Liu, L, Battaile, K.P, Nguyen, H.N, Chamandi, S.D, Picard, H.R, Madden, T.K, Thruman, H.A, Kim, Y, Groutas, W.C, Chang, K.O. | 登録日 | 2022-06-24 | 公開日 | 2022-07-06 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Broad-Spectrum Cyclopropane-Based Inhibitors of Coronavirus 3C-like Proteases: Biochemical, Structural, and Virological Studies. Acs Pharmacol Transl Sci, 6, 2023
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8DGX
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8DGU
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8DGV
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8DGW
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7Y7J
| SARS-CoV-2 S trimer in complex with 1F Fab | 分子名称: | 1F VH, 1F VL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhao, S, Liu, F, Yang, X, Zhong, G. | 登録日 | 2022-06-22 | 公開日 | 2023-02-22 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | A core epitope targeting antibody of SARS-CoV-2. Protein Cell, 14, 2023
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7Y7K
| SARS-CoV-2 RBD in complex with 1F Fab | 分子名称: | 1F VH, 1F VL, Spike protein S1 | 著者 | Zhao, S, Liu, F, Yang, X, Zhong, G. | 登録日 | 2022-06-22 | 公開日 | 2023-02-22 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | A core epitope targeting antibody of SARS-CoV-2. Protein Cell, 14, 2023
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7Y6L
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7Y6N
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8DDL
| SARS-CoV-2 Main Protease (Mpro) H163A Mutant Apo Structure | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ORF1a polyprotein, ... | 著者 | Tran, N, McLeod, M.J, Kalyaanamoorthy, S, Ganesan, A, Holyoak, T. | 登録日 | 2022-06-18 | 公開日 | 2023-06-28 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | The H163A mutation unravels an oxidized conformation of the SARS-CoV-2 main protease. Nat Commun, 14, 2023
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8DDI
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8DDM
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8DD6
| SARS-CoV-2 Main Protease (Mpro) H163A Mutant in Complex with GC376 | 分子名称: | (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, DIMETHYL SULFOXIDE, ORF1a polyprotein | 著者 | Tran, N, McLeod, M.J, Kalyaanamoorthy, S, Ganesan, A, Holyoak, T. | 登録日 | 2022-06-17 | 公開日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The H163A mutation unravels an oxidized conformation of the SARS-CoV-2 main protease. Nat Commun, 14, 2023
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8DAO
| Crystal structure of SARS-CoV-2 spike stem fusion peptide in complex with neutralizing antibody COV44-79 | 分子名称: | COV44-79 heavy chain constant domain, COV44-79 heavy chain variable domain, COV44-79 light chain constant domain, ... | 著者 | Lin, T.H, Lee, C.C.D, Yuan, M, Wilson, I.A. | 登録日 | 2022-06-13 | 公開日 | 2022-07-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Broadly neutralizing antibodies target the coronavirus fusion peptide. Science, 377, 2022
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7Y42
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8A4T
| crystal structures of diastereomer (S,S,S)-13b (13b-K) in complex with the SARS-CoV-2 Mpro | 分子名称: | 3C-like proteinase nsp5, CHLORIDE ION, ~{tert}-butyl ~{N}-[1-[(2~{S})-3-cyclopropyl-1-oxidanylidene-1-[[(2~{S},3~{R})-3-oxidanyl-4-oxidanylidene-1-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]amino]propan-2-yl]-2-oxidanylidene-pyridin-3-yl]carbamate | 著者 | Ibrahim, M, Hilgenfeld, R, Zhang, L. | 登録日 | 2022-06-13 | 公開日 | 2022-10-12 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Diastereomeric Resolution Yields Highly Potent Inhibitor of SARS-CoV-2 Main Protease. J.Med.Chem., 65, 2022
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8A4Q
| crystal structures of diastereomer (R,S,S)-13b (13b-H) in complex with the SARS-CoV-2 Mpro. | 分子名称: | 3C-like proteinase nsp5, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | 著者 | Ibrahim, M, Hilgenfeld, R, Zhang, L. | 登録日 | 2022-06-13 | 公開日 | 2022-10-12 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Diastereomeric Resolution Yields Highly Potent Inhibitor of SARS-CoV-2 Main Protease. J.Med.Chem., 65, 2022
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7Y3N
| Crystal structure of SARS-CoV receptor binding domain in complex with human antibody BIOLS56 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of BIOLS56, ... | 著者 | Rao, X, Chai, Y, Wu, Y, Gao, F. | 登録日 | 2022-06-11 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.97 Å) | 主引用文献 | Defining a de novo non-RBM antibody as RBD-8 and its synergistic rescue of immune-evaded antibodies to neutralize Omicron SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 120, 2023
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7Y3O
| Crystal structure of SARS-CoV-2 receptor binding domain in complex with human antibody BIOLS56 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of BIOLS56, Light chain of BIOLS56, ... | 著者 | Rao, X, Gao, F, Wu, Y, Gao, F. | 登録日 | 2022-06-11 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Defining a de novo non-RBM antibody as RBD-8 and its synergistic rescue of immune-evaded antibodies to neutralize Omicron SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 120, 2023
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7Y1Y
| S-ECD (Omicron BA.2) in complex with PD of ACE2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ... | 著者 | Li, Y.N, Shen, Y.P, Zhang, Y.Y, Yan, R.H. | 登録日 | 2022-06-09 | 公開日 | 2023-07-12 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural Basis for the Enhanced Infectivity and Immune Evasion of Omicron Subvariants. Viruses, 15, 2023
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7Y1Z
| S-ECD (Omicron BA.3) in complex with three PD of ACE2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ... | 著者 | Li, Y.N, Shen, Y.P, Zhang, Y.Y, Yan, R.H. | 登録日 | 2022-06-09 | 公開日 | 2023-07-12 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural Basis for the Enhanced Infectivity and Immune Evasion of Omicron Subvariants. Viruses, 15, 2023
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5SQ0
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5SPZ
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5SRW
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5SSB
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