7OBH
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7OBD
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4DAU
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3SMM
| Crystal structure of human 14-3-3 sigma C38N/N166H in complex with task-3 peptide and stabilizer Fusicoccin J aglycone | 分子名称: | 14-3-3 protein sigma, CHLORIDE ION, Fusicoccin J aglycone, ... | 著者 | Anders, C, Schumacher, B, Ottmann, C. | 登録日 | 2011-06-28 | 公開日 | 2012-07-11 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface. Chem. Biol., 20, 2013
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3SMN
| Crystal structure of human 14-3-3 sigma C38N/N166H in complex with task-3 peptide and stabilizer Fusicoccin A-THF | 分子名称: | 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... | 著者 | Anders, C, Schumacher, B, Ottmann, C. | 登録日 | 2011-06-28 | 公開日 | 2012-07-11 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface. Chem. Biol., 20, 2013
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6A5Q
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6SLW
| Fragment AZ-004 binding at the TAZpS89/14-3-3 sigma interface | 分子名称: | 14-3-3 protein sigma, 4-methyl-5-phenyl-thiophene-2-carboximidamide, WW domain-containing transcription regulator protein 1 | 著者 | Ottmann, C, Wolter, M, Guillory, X, Leysen, S, Genet, S, Somsen, B, Patel, J, Castaldi, P. | 登録日 | 2019-08-20 | 公開日 | 2020-06-17 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
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2C1N
| Molecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-3 | 分子名称: | 14-3-3 PROTEIN ZETA/DELTA, HISTONE H3 ACETYLPHOSPHOPEPTIDE | 著者 | Welburn, J.P.I, Macdonald, N, Noble, M.E.M, Nguyen, A, Yaffe, M.B, Clynes, D, Moggs, J.G, Orphanides, G, Thomson, S, Edmunds, J.W, Clayton, A.L, Endicott, J.A, Mahadevan, L.C. | 登録日 | 2005-09-16 | 公開日 | 2005-11-02 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Molecular Basis for the Recognition of Phosphorylated and Phosphoacetylated Histone H3 by 14-3-3. Mol.Cell, 20, 2005
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6KZG
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7D8P
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6S3C
| Fragment AZ-019 binding at the p53pT387/14-3-3 sigma interface | 分子名称: | 14-3-3 protein sigma, 4-phenyl-5-(piperidin-4-ylmethyl)thiophene-2-carboximidamide, CHLORIDE ION, ... | 著者 | Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Castaldi, P, Ottmann, C. | 登録日 | 2019-06-25 | 公開日 | 2020-06-17 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
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1QJB
| 14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 1) | 分子名称: | 14-3-3 PROTEIN ZETA/DELTA, PHOSPHOPEPTIDE | 著者 | Rittinger, K, Budman, J, Xu, J, Volinia, S, Cantley, L.C, Smerdon, S.J, Gamblin, S.J, Yaffe, M.B. | 登録日 | 1999-06-23 | 公開日 | 1999-09-15 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding Mol.Cell, 4, 1999
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3O8I
| Structure of 14-3-3 isoform sigma in complex with a C-Raf1 peptide and a stabilizing small molecule fragment | 分子名称: | 14-3-3 binding site peptide of RAF proto-oncogene serine/threonine-protein kinase, 14-3-3 protein sigma, 6,6-dihydroxy-1-methoxyhexan-2-one | 著者 | Ottmann, C, Rose, R, Kaiser, M, Kuhenne, P. | 登録日 | 2010-08-03 | 公開日 | 2010-09-29 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Impaired Binding of 14-3-3 to C-RAF in Noonan Syndrome Suggests New Approaches in Diseases with Increased Ras Signaling Mol.Cell.Biol., 30, 2010
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7QIK
| SARS-CoV-2 Nucleocapsid phosphopeptide 193-200 bound to human 14-3-3 sigma | 分子名称: | 14-3-3 protein sigma, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BROMIDE ION, ... | 著者 | Sluchanko, N.N, Tugaeva, K.V, Smith, J.L.R, Antson, A.A. | 登録日 | 2021-12-15 | 公開日 | 2021-12-29 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | SARS-CoV-2 Nucleocapsid phosphopeptide 193-200 bound to human 14-3-3 sigma To Be Published
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6YMO
| Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pS617 peptide | 分子名称: | 14-3-3 protein zeta/delta, 2-HYDROXYBENZOIC ACID, Glucocorticoid receptor, ... | 著者 | Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C. | 登録日 | 2020-04-09 | 公開日 | 2021-03-24 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators. J.Biol.Chem., 296, 2021
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6T5H
| Human 14-3-3 sigma fused to the StARD1 peptide including phosphoserine-57 | 分子名称: | 14-3-3 protein sigma,Steroidogenic acute regulatory protein, mitochondrial, IMIDAZOLE, ... | 著者 | Sluchanko, N.N, Tugaeva, K.V, Titterington, J, Antson, A.A. | 登録日 | 2019-10-16 | 公開日 | 2020-11-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Molecular basis for the recognition of steroidogenic acute regulatory protein by the 14-3-3 protein family. Febs J., 287, 2020
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6YOX
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4JC3
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6YGJ
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5NWJ
| 14-3-3c in complex with CPP7 | 分子名称: | 14-3-3-like protein C, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Saponaro, A, Porro, A, Chaves-Sanjuan, A, Nardini, M, Thiel, G, Moroni, A. | 登録日 | 2017-05-06 | 公開日 | 2017-11-22 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Fusicoccin Activates KAT1 Channels by Stabilizing Their Interaction with 14-3-3 Proteins. Plant Cell, 29, 2017
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3EFZ
| Crystal Structure of a 14-3-3 protein from cryptosporidium parvum (cgd1_2980) | 分子名称: | 1,2-ETHANEDIOL, 14-3-3 protein | 著者 | Wernimont, A.K, Dong, A, Qiu, W, Lew, J, Wasney, G.A, Vedadi, M, Kozieradzki, I, Zhao, Y, Ren, H, Alam, Z, Lin, Y.H, Sundstrom, M, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Hui, R, Brokx, S, Structural Genomics Consortium (SGC) | 登録日 | 2008-09-10 | 公開日 | 2008-09-23 | 最終更新日 | 2012-02-22 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | Characterization of 14-3-3 proteins from Cryptosporidium parvum. Plos One, 6, 2011
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5NAS
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6YO8
| Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pT524 peptide | 分子名称: | 14-3-3 protein zeta/delta, Glucocorticoid receptor | 著者 | Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C. | 登録日 | 2020-04-14 | 公開日 | 2021-03-24 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators. J.Biol.Chem., 296, 2021
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6A5S
| Structure of 14-3-3 gamma in complex with TFEB 14-3-3 binding motif | 分子名称: | 14-3-3 protein gamma, MAGNESIUM ION, SODIUM ION, ... | 著者 | Xu, Y, Ren, J.Q, Feng, W. | 登録日 | 2018-06-25 | 公開日 | 2019-02-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.099 Å) | 主引用文献 | YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization. Autophagy, 15, 2019
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8BWH
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