PDB: 608 件ウェブページステータス検索Chemie searchBIRD

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7D8P	CRTC1 pSer151 peptide in complex with 14-3-3 zeta 分子名称: 14-3-3 protein zeta/delta, CRTC1 pSer151 peptide, GLYCEROL 著者 Chen, H, Zhang, H, Xiang, S. 登録日 2020-10-08 公開日 2021-02-24 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Insights into the Interaction Between CRTCs and 14-3-3. J.Mol.Biol., 433, 2021
6A5Q	Structure of 14-3-3 beta in complex with TFEB 14-3-3 binding motif 分子名称: 14-3-3 protein beta/alpha, MALONIC ACID, TFEB pS211-peptide 著者 Xu, Y, Ren, J.Q, Feng, W. 登録日 2018-06-25 公開日 2019-02-13 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization. Autophagy, 15, 2019
7O3S	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-045 分子名称: 14-3-3 protein sigma, 3-methoxy-1-(4-methylphenyl)sulfonyl-azetidine, CHLORIDE ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-04-02 公開日 2021-06-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7O6F	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-178 分子名称: 14-3-3 protein sigma, 4-[4-(2-hydroxyethyl)piperidin-1-yl]carbonylbenzaldehyde, CALCIUM ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-04-11 公開日 2021-06-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
1QJA	14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 2) 分子名称: 14-3-3 PROTEIN ZETA, PHOSPHOPEPTIDE 著者 Rittinger, K, Budman, J, Xu, J, Volinia, S, Cantley, L.C, Smerdon, S.J, Gamblin, S.J, Yaffe, M.B. 登録日 1999-06-23 公開日 1999-09-15 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding Mol.Cell, 4, 1999
3SMM	Crystal structure of human 14-3-3 sigma C38N/N166H in complex with task-3 peptide and stabilizer Fusicoccin J aglycone 分子名称: 14-3-3 protein sigma, CHLORIDE ION, Fusicoccin J aglycone, ... 著者 Anders, C, Schumacher, B, Ottmann, C. 登録日 2011-06-28 公開日 2012-07-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface. Chem. Biol., 20, 2013
7QIK	SARS-CoV-2 Nucleocapsid phosphopeptide 193-200 bound to human 14-3-3 sigma 分子名称: 14-3-3 protein sigma, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BROMIDE ION, ... 著者 Sluchanko, N.N, Tugaeva, K.V, Smith, J.L.R, Antson, A.A. 登録日 2021-12-15 公開日 2021-12-29 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 SARS-CoV-2 Nucleocapsid phosphopeptide 193-200 bound to human 14-3-3 sigma To Be Published
6YMO	Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pS617 peptide 分子名称: 14-3-3 protein zeta/delta, 2-HYDROXYBENZOIC ACID, Glucocorticoid receptor, ... 著者 Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C. 登録日 2020-04-09 公開日 2021-03-24 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators. J.Biol.Chem., 296, 2021
6T5H	Human 14-3-3 sigma fused to the StARD1 peptide including phosphoserine-57 分子名称: 14-3-3 protein sigma,Steroidogenic acute regulatory protein, mitochondrial, IMIDAZOLE, ... 著者 Sluchanko, N.N, Tugaeva, K.V, Titterington, J, Antson, A.A. 登録日 2019-10-16 公開日 2020-11-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Molecular basis for the recognition of steroidogenic acute regulatory protein by the 14-3-3 protein family. Febs J., 287, 2020
4JC3	14-3-3 protein interaction with Estrogen Receptor Alpha provides a novel drug target interface 分子名称: 14-3-3 protein sigma, Estrogen receptor Peptide, MAGNESIUM ION 著者 Bier, D, Ottmann, C. 登録日 2013-02-21 公開日 2013-05-15 最終更新日 2017-06-07 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface. Proc. Natl. Acad. Sci. U.S.A., 110, 2013
6YOX	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-027 分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2020-04-15 公開日 2020-09-23 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Fragment-Based Stabilizers of Protein-Protein Interactions through Imine-Based Tethering. Angew.Chem.Int.Ed.Engl., 59, 2020
6YGJ	small-molecule stabilizer of 14-3-3 and the Carbohydrate Response Element Binding Protein (ChREBP) protein-protein interaction 分子名称: 14-3-3 protein beta/alpha, Carbohydrate-responsive element-binding protein, [2-[2-oxidanylidene-2-(2-phenylethylamino)ethoxy]phenyl]phosphonic acid 著者 Ottmann, C, Visser, E.J. 登録日 2020-03-27 公開日 2020-09-16 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein-protein interactions. Nat Commun, 11, 2020
5NWJ	14-3-3c in complex with CPP7 分子名称: 14-3-3-like protein C, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Saponaro, A, Porro, A, Chaves-Sanjuan, A, Nardini, M, Thiel, G, Moroni, A. 登録日 2017-05-06 公開日 2017-11-22 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Fusicoccin Activates KAT1 Channels by Stabilizing Their Interaction with 14-3-3 Proteins. Plant Cell, 29, 2017
3EFZ	Crystal Structure of a 14-3-3 protein from cryptosporidium parvum (cgd1_2980) 分子名称: 1,2-ETHANEDIOL, 14-3-3 protein 著者 Wernimont, A.K, Dong, A, Qiu, W, Lew, J, Wasney, G.A, Vedadi, M, Kozieradzki, I, Zhao, Y, Ren, H, Alam, Z, Lin, Y.H, Sundstrom, M, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Hui, R, Brokx, S, Structural Genomics Consortium (SGC) 登録日 2008-09-10 公開日 2008-09-23 最終更新日 2012-02-22 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Characterization of 14-3-3 proteins from Cryptosporidium parvum. Plos One, 6, 2011
5NAS	Crystal structure of human 14-3-3 zeta in complex with PI4KIIIB peptide 分子名称: 14-3-3 protein zeta/delta, Phosphatidylinositol 4-kinase beta 著者 Boura, E, Eisenreichova, A. 登録日 2017-02-28 公開日 2017-03-29 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Crystal structure of human 14-3-3 zeta in complex with PI4KIIIB peptide To Be Published
6YO8	Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pT524 peptide 分子名称: 14-3-3 protein zeta/delta, Glucocorticoid receptor 著者 Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C. 登録日 2020-04-14 公開日 2021-03-24 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators. J.Biol.Chem., 296, 2021
6A5S	Structure of 14-3-3 gamma in complex with TFEB 14-3-3 binding motif 分子名称: 14-3-3 protein gamma, MAGNESIUM ION, SODIUM ION, ... 著者 Xu, Y, Ren, J.Q, Feng, W. 登録日 2018-06-25 公開日 2019-02-13 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.099 Å) 主引用文献 YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization. Autophagy, 15, 2019
7OBY	Crystal structure of 14-3-3 sigma in complex with SSBP4 phosphopeptide and stabilizer Fusicoccin-A 分子名称: 14-3-3 protein sigma, CHLORIDE ION, FUSICOCCIN, ... 著者 Centorrino, F, Andlovic, B, Ottmann, C. 登録日 2021-04-24 公開日 2022-05-04 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
8BWH	Small molecule stabilizer for 14-3-3/ChREBP (Cmd 42) 分子名称: 14-3-3 protein sigma, Carbohydrate-responsive element-binding protein, MAGNESIUM ION, ... 著者 Pennings, M.A.M, Visser, E.J, Ottmann, C. 登録日 2022-12-06 公開日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. Biorxiv, 2024
5YQG	The structure of 14-3-3 and pNumb peptide 分子名称: 14-3-3 protein eta, Peptide from Protein numb homolog 著者 Chen, X, Liu, Z, Wen, W. 登録日 2017-11-06 公開日 2018-02-07 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural determinants controlling 14-3-3 recruitment to the endocytic adaptor Numb and dissociation of the Numb/alpha-adaptin complex. J. Biol. Chem., 293, 2018
5D2D	Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768 分子名称: 14-3-3 protein zeta/delta, CHLORIDE ION, Cystic fibrosis transmembrane conductance regulator, ... 著者 Stevers, L.M, Leysen, S.F.R, Ottmann, C. 登録日 2015-08-05 公開日 2016-03-16 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR. Proc.Natl.Acad.Sci.USA, 113, 2016
4JDD	14-3-3 protein interaction with Estrogen Receptor Alpha provides a novel drug target interface 分子名称: 14-3-3 protein sigma, Estrogen receptor Peptide, FUSICOCCIN 著者 Bier, D, Ottmann, C. 登録日 2013-02-25 公開日 2013-05-15 最終更新日 2017-06-07 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface. Proc. Natl. Acad. Sci. U.S.A., 110, 2013
3SMK	Crystal structure of human 14-3-3 sigma C38V/N166H in complex with TASK-3 peptide and stabilizer Cotylenin A 分子名称: 14-3-3 protein sigma, Cotylenin A, MAGNESIUM ION, ... 著者 Anders, C, Schumacher, B, Ottmann, C. 登録日 2011-06-28 公開日 2012-07-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface. Chem. Biol., 20, 2013
6YR7	14-3-3 sigma in complex with hDMX-342+367 peptide 分子名称: 14-3-3 protein sigma, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Protein Mdm4 著者 Wolter, M, Srdanovic, S, Warriner, S, Wilson, A, Ottmann, C. 登録日 2020-04-19 公開日 2021-11-03 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.105 Å) 主引用文献 Understanding the interaction of 14-3-3 proteins with hDMX and hDM2: a structural and biophysical study. Febs J., 2022
6FNC	Mono- and bivalent 14-3-3 inhibitors for characterizing supramolecular lysine-PEG interactions in proteins 分子名称: 14-3-3 protein zeta/delta, BENZOIC ACID, CALCIUM ION, ... 著者 Bier, D, Ottann, C. 登録日 2018-02-02 公開日 2018-07-04 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Mono- and Bivalent 14-3-3 Inhibitors for Characterizing Supramolecular "Lysine Wrapping" of Oligoethylene Glycol (OEG) Moieties in Proteins. Chemistry, 24, 2018

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