PDB: 1327 件ウェブページステータス検索Chemie searchBIRD

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2Q3H	The crystal structure of RhouA in the GDP-bound state. 分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras homolog gene family, ... 著者 Gileadi, C, Yang, X, Papagrigoriou, E, Elkins, J, Zhao, Y, Bray, J, Gileadi, O, Umeano, C, Ugochukwu, E, Uppenberg, J, Bunkoczi, G, von Delft, F, Pike, A.C.W, Phillips, C, Savitsky, P, Fedorov, O, Edwards, A, Weigelt, J, Arrowsmith, C.H, Sundstrom, M, Doyle, D.A, Structural Genomics Consortium (SGC) 登録日 2007-05-30 公開日 2007-06-19 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 The crystal structure of RhouA in the GDP-bound state. To be Published
2Q21	CRYSTAL STRUCTURES AT 2.2 ANGSTROMS RESOLUTION OF THE CATALYTIC DOMAINS OF NORMAL RAS PROTEIN AND AN ONCOGENIC MUTANT COMPLEXED WITH GSP 分子名称: C-H-RAS P21 PROTEIN CATALYTIC DOMAIN, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Kim, S.-H. 登録日 1991-09-25 公開日 1992-07-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structures at 2.2 A resolution of the catalytic domains of normal ras protein and an oncogenic mutant complexed with GDP. J.Mol.Biol., 217, 1991
2QRZ	Cdc42 bound to GMP-PCP: Induced Fit by Effector is Required 分子名称: Cell division control protein 42 homolog precursor, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... 著者 Phillips, M.J, Calero, G, Chan, B, Cerione, R.A. 登録日 2007-07-30 公開日 2008-03-18 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Effector Proteins Exert an Important Influence on the Signaling-active State of the Small GTPase Cdc42. J.Biol.Chem., 283, 2008
2QUZ	Crystal Structure of the activating H-RasK117R mutant in Costello Syndrome, bound to Mg-GDP 分子名称: GTPase HRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Parret, A, Scheffzek, K. 登録日 2007-08-07 公開日 2007-12-11 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Mutation analysis in Costello syndrome: functional and structural characterization of the HRAS p.Lys117Arg mutation. Hum.Mutat., 29, 2008
2RGD	Crystal structure of H-RasQ61L-GppNHp 分子名称: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... 著者 Buhrman, G, Wink, G, Mattos, C. 登録日 2007-10-03 公開日 2007-12-18 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Transformation Efficiency of RasQ61 Mutants Linked to Structural Features of the Switch Regions in the Presence of Raf. Structure, 15, 2007
2RGE	Crystal structure of H-Ras-GppNHp 分子名称: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... 著者 Buhrman, G, Wink, G, Mattos, C. 登録日 2007-10-03 公開日 2007-12-18 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Transformation Efficiency of RasQ61 Mutants Linked to Structural Features of the Switch Regions in the Presence of Raf. Structure, 15, 2007
2RGB	Crystal structure of H-RasQ61K-GppNHp 分子名称: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... 著者 Buhrman, G, Wink, G, Mattos, C. 登録日 2007-10-03 公開日 2007-12-18 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Transformation Efficiency of RasQ61 Mutants Linked to Structural Features of the Switch Regions in the Presence of Raf. Structure, 15, 2007
2RGG	Crystal structure of H-RasQ61I-GppNHp, trigonal crystal form 分子名称: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER 著者 Buhrman, G, Wink, G, Mattos, C. 登録日 2007-10-03 公開日 2007-12-18 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Transformation Efficiency of RasQ61 Mutants Linked to Structural Features of the Switch Regions in the Presence of Raf. Structure, 15, 2007
2RGA	Crystal structure of H-RasQ61I-GppNHp 分子名称: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... 著者 Buhrman, G, Wink, G, Mattos, C. 登録日 2007-10-03 公開日 2007-12-18 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Transformation Efficiency of RasQ61 Mutants Linked to Structural Features of the Switch Regions in the Presence of Raf. Structure, 15, 2007
2RGC	Crystal structure of H-RasQ61V-GppNHp 分子名称: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... 著者 Buhrman, G, Wink, G, Mattos, C. 登録日 2007-10-03 公開日 2007-12-18 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Transformation Efficiency of RasQ61 Mutants Linked to Structural Features of the Switch Regions in the Presence of Raf. Structure, 15, 2007
2RAP	THE SMALL G PROTEIN RAP2A IN COMPLEX WITH GTP 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RAP2A 著者 Cherfils, J, Menetrey, J, Lebras, G. 登録日 1998-05-06 公開日 1998-06-17 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS. EMBO J., 16, 1997
2UZI	Crystal structure of HRAS(G12V) - anti-RAS Fv complex 分子名称: ANTI-RAS FV HEAVY CHAIN, ANTI-RAS FV LIGHT CHAIN, GTPASE HRAS, ... 著者 Tanaka, T, williams, R.L, Rabbitts, T.H. 登録日 2007-04-27 公開日 2007-06-26 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Tumour Prevention by a Single Antibody Domain Targeting the Interaction of Signal Transduction Proteins with Ras. Embo J., 26, 2007
2VH5	CRYSTAL STRUCTURE OF HRAS(G12V) - ANTI-RAS FV (disulfide free mutant) COMPLEX 分子名称: ANTI-RAS FV HEAVY CHAIN, ANTI-RAS FV LIGHT CHAIN, GTPASE HRAS, ... 著者 Tanaka, T, Williams, R.L, Rabbitts, T.H. 登録日 2007-11-19 公開日 2008-01-22 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Functional Intracellular Antibody Fragments Do not Require Invariant Intra-Domain Disulfide Bonds. J.Mol.Biol., 376, 2008
2W2X	Complex of Rac2 and PLCg2 spPH Domain 分子名称: 1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, ... 著者 Opaleye, O, Bunney, T.D, Roe, S.M, Pearl, L.H. 登録日 2008-11-04 公開日 2009-05-05 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural Insights Into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2. Mol.Cell, 34, 2009
2W2V	Rac2 (G12V) in complex with GTPgS 分子名称: GUANOSINE-5'-TRIPHOSPHATE, RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2 著者 Opaleye, O, Bunney, T.D, Roe, S.M, Pearl, L.H. 登録日 2008-11-04 公開日 2009-05-05 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Insights Into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2. Mol.Cell, 34, 2009
2W2T	Rac2 (G12V) in complex with GDP 分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2 著者 Opaleye, O, Bunney, T.D, Roe, S.M, Pearl, L.H. 登録日 2008-11-04 公開日 2009-05-05 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural Insights Into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2. Mol.Cell, 34, 2009
4LYH	Crystal Structure of small molecule vinylsulfonamide 9 covalently bound to K-Ras G12C 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, N-{1-[N-(4-chloro-5-iodo-2-methoxyphenyl)glycyl]piperidin-4-yl}ethanesulfonamide, ... 著者 Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. 登録日 2013-07-31 公開日 2013-11-27 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.371 Å) 主引用文献 K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
4M22	Crystal Structure of small molecule acrylamide 16 covalently bound to K-Ras G12C 分子名称: 1-{4-[(2,4-dichlorophenoxy)acetyl]piperazin-1-yl}propan-1-one, GUANOSINE-5'-DIPHOSPHATE, K-Ras GTPase, ... 著者 Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. 登録日 2013-08-05 公開日 2013-11-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
4LUC	Crystal Structure of small molecule disulfide 6 bound to K-Ras G12C 分子名称: CALCIUM ION, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. 登録日 2013-07-25 公開日 2013-11-27 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.29 Å) 主引用文献 K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
4LPK	Crystal Structure of K-Ras WT, GDP-bound 分子名称: CALCIUM ION, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. 登録日 2013-07-16 公開日 2013-11-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
4M1T	Crystal Structure of small molecule vinylsulfonamide 14 covalently bound to K-Ras G12C 分子名称: GUANOSINE-5'-DIPHOSPHATE, K-Ras GTPase, N-{1-[(2,4-dichlorophenoxy)acetyl]piperidin-4-yl}ethanesulfonamide 著者 Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. 登録日 2013-08-04 公開日 2013-11-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.703 Å) 主引用文献 K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
4M1S	Crystal Structure of small molecule vinylsulfonamide 13 covalently bound to K-Ras G12C 分子名称: GUANOSINE-5'-DIPHOSPHATE, K-Ras GTPase, N-{1-[N-(2,4-dichlorophenyl)glycyl]piperidin-4-yl}ethanesulfonamide 著者 Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. 登録日 2013-08-04 公開日 2013-11-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.552 Å) 主引用文献 K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
4LRW	Crystal Structure of K-Ras G12C (cysteine-light), GDP-bound 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. 登録日 2013-07-21 公開日 2013-11-27 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.151 Å) 主引用文献 K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
4LYJ	Crystal Structure of small molecule vinylsulfonamide 9 covalently bound to K-Ras G12C, alternative space group 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. 登録日 2013-07-31 公開日 2013-11-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.927 Å) 主引用文献 K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
4LV6	Crystal Structure of small molecule disulfide 4 covalently bound to K-Ras G12C 分子名称: 1-[(2,4-dichlorophenoxy)acetyl]-N-(2-sulfanylethyl)piperidine-4-carboxamide, CALCIUM ION, GTPase KRas, ... 著者 Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. 登録日 2013-07-26 公開日 2013-11-27 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013

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