8G47
KRAS G12C complex with GDP and AMG 510 imaged on a cryo-EM imaging scaffold
Summary for 8G47
| Entry DOI | 10.2210/pdb8g47/pdb |
| EMDB information | 29715 |
| Descriptor | RCG-33 - Cryo-EM imaging scaffold subunit B fused to DARPin, GTPase KRas, MAGNESIUM ION, ... (5 entities in total) |
| Functional Keywords | cryoem imaging scaffold, cancer, gtpase, signaling protein |
| Biological source | synthetic construct More |
| Total number of polymer chains | 2 |
| Total formula weight | 58104.83 |
| Authors | Castells-Graells, R.,Sawaya, M.R.,Yeates, T.O. (deposition date: 2023-02-08, release date: 2023-08-09, Last modification date: 2023-09-27) |
| Primary citation | Castells-Graells, R.,Meador, K.,Arbing, M.A.,Sawaya, M.R.,Gee, M.,Cascio, D.,Gleave, E.,Debreczeni, J.E.,Breed, J.,Leopold, K.,Patel, A.,Jahagirdar, D.,Lyons, B.,Subramaniam, S.,Phillips, C.,Yeates, T.O. Cryo-EM structure determination of small therapeutic protein targets at 3 angstrom -resolution using a rigid imaging scaffold. Proc.Natl.Acad.Sci.USA, 120:e2305494120-e2305494120, 2023 Cited by PubMed: 37669364DOI: 10.1073/pnas.2305494120 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.19 Å) |
Structure validation
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