PDB: 594 件ウェブページステータス検索Chemie searchBIRD

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6CMS	Closed structure of active SHP2 mutant E76K bound to SHP099 inhibitor 分子名称: 6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine, Tyrosine-protein phosphatase non-receptor type 11 著者 Padua, R.A.P, Sun, Y, Marko, I, Pitsawong, W, Kern, D. 登録日 2018-03-06 公開日 2018-11-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2. Nat Commun, 9, 2018
6CMP	Closed structure of inactive SHP2 mutant C459E 分子名称: Tyrosine-protein phosphatase non-receptor type 11 著者 Padua, R.A.P, Sun, Y, Marko, I, Pitsawong, W, Kern, D. 登録日 2018-03-06 公開日 2018-11-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2. Nat Commun, 9, 2018
6CMQ	Structure of human SHP2 without N-SH2 domain 分子名称: Tyrosine-protein phosphatase non-receptor type 11 著者 Padua, R.A.P, Sun, Y, Marko, I, Pitsawong, W, Kern, D. 登録日 2018-03-06 公開日 2018-11-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2. Nat Commun, 9, 2018
6CRG	Crystal Structure of Shp2 E76K GOF Mutant in complex with SHP099 分子名称: 6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine, GLYCEROL, SULFATE ION, ... 著者 Stams, T, Fodor, M. 登録日 2018-03-17 公開日 2018-11-07 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition. Nat Commun, 9, 2018
6CRF	Crystal Structure of Shp2 E76K GOF Mutant in the Open Conformation 分子名称: GLYCEROL, Tyrosine-protein phosphatase non-receptor type 11 著者 Stams, T, Fodor, M. 登録日 2018-03-17 公開日 2018-11-07 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.62 Å) 主引用文献 Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition. Nat Commun, 9, 2018
6E2P	Structure of human JAK2 FERM/SH2 in complex with Leptin Receptor 分子名称: Leptin receptor, SULFATE ION, Tyrosine-protein kinase JAK2 著者 Ferrao, R, Lupardus, P.J, Wallweber, H.J.A. 登録日 2018-07-11 公開日 2018-08-08 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.83 Å) 主引用文献 Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation. Elife, 7, 2018
6E2Q	Structure of human JAK2 FERM/SH2 in complex with Erythropoietin Receptor 分子名称: Erythropoietin receptor, Tyrosine-protein kinase JAK2 著者 Ferrao, R, Lupardus, P.J. 登録日 2018-07-11 公開日 2018-08-08 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation. Elife, 7, 2018
6E8H	Legionella Longbeachae LeSH (Llo2327) 分子名称: CHLORIDE ION, LeSH (Llo2327) 著者 Kaneko, T, Li, S.S.C. 登録日 2018-07-29 公開日 2018-11-14 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Identification and characterization of a large family of superbinding bacterial SH2 domains. Nat Commun, 9, 2018
6E8I	Legionella Longbeachae LeSH (Llo2327) bound to phosphotyrosine 分子名称: LeSH (Llo2327), O-PHOSPHOTYROSINE 著者 Kaneko, T, Li, S.S.C. 登録日 2018-07-29 公開日 2018-11-14 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Identification and characterization of a large family of superbinding bacterial SH2 domains. Nat Commun, 9, 2018
6E8K	Legionella Longbeachae LeSH (Llo2327) bound to the human interleukin-2 receptor beta pTyr387 peptide 分子名称: LeSH (Llo2327), interleukin-2 receptor beta pTyr387 peptide 著者 Kaneko, T, Li, S.S.C. 登録日 2018-07-30 公開日 2018-11-14 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Identification and characterization of a large family of superbinding bacterial SH2 domains. Nat Commun, 9, 2018
6E8M	Legionella Longbeachae LeSH (Llo2327) bound to the human DnaJ-A1 pTyr381 peptide 分子名称: DnaJ-A1 pTyr381 peptide, LeSH (Llo2327) 著者 Kaneko, T, Li, S.S.C. 登録日 2018-07-30 公開日 2018-11-14 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 Identification and characterization of a large family of superbinding bacterial SH2 domains. Nat Commun, 9, 2018
6MBW	Structure of Transcription Factor 分子名称: Signal transducer and activator of transcription 5B 著者 Seo, H.-S, Dhe-Paganon, S. 登録日 2018-08-30 公開日 2019-06-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.29 Å) 主引用文献 Structural and functional consequences of the STAT5BN642H driver mutation. Nat Commun, 10, 2019
6MBZ	Structure of Transcription Factor 分子名称: Signal transducer and activator of transcription 5B 著者 Seo, H.-S, Dhe-Paganon, S. 登録日 2018-08-30 公開日 2019-06-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.21 Å) 主引用文献 Structural and functional consequences of the STAT5BN642Hdriver mutation. Nat Commun, 10, 2019
6MD7	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Pyrimidinone 7 分子名称: 2-[4-(aminomethyl)-4-methylpiperidin-1-yl]-5-{[2-(trifluoromethyl)pyridin-3-yl]sulfanyl}pyrimidin-4(3H)-one, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 11 著者 Fodor, M, Stams, T. 登録日 2018-09-04 公開日 2019-02-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors. J. Med. Chem., 62, 2019
6MDB	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Pyrazolo-pyrimidinone 5 分子名称: 6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)-5-methyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 11 著者 Fodor, M, Stams, T. 登録日 2018-09-04 公開日 2019-02-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors. J. Med. Chem., 62, 2019
6MDC	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Pyrazolo-pyrimidinone 1 SHP389 分子名称: 6-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-[3-chloro-2-(cyclopropylamino)pyridin-4-yl]-5-methyl-2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 11 著者 Fodor, M, Stams, T. 登録日 2018-09-04 公開日 2019-02-13 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors. J. Med. Chem., 62, 2019
6MD9	NON-RECEPTOR PROTEIN TYROSINE PHOSPHATASE SHP2 IN COMPLEX WITH ALLOSTERIC INHIBITOR Isoxazolo-pyridinone 3 分子名称: 3-(2-chlorophenyl)-6-{4-[(dimethylamino)methyl]phenyl}-5-methyl[1,2]oxazolo[4,5-c]pyridin-4(5H)-one, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 11 著者 Fodor, M, Stams, T. 登録日 2018-09-04 公開日 2019-02-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors. J. Med. Chem., 62, 2019
6MDA	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Pyrazolo-pyridine 4 分子名称: 3-(4-bromophenyl)-6-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 11 著者 Fodor, M, Stams, T. 登録日 2018-09-04 公開日 2019-02-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors. J. Med. Chem., 62, 2019
6MDD	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Imidazo-pyridine 24 分子名称: 5-[(2,3-dichlorophenyl)sulfanyl]-3H-imidazo[4,5-b]pyridin-2-amine, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 11 著者 Fodor, M, Stams, T. 登録日 2018-09-04 公開日 2019-02-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors. J. Med. Chem., 62, 2019
6ICH	Grb2 SH2 domain in domain swapped dimer form 分子名称: Growth factor receptor-bound protein 2 著者 Hosoe, Y, Numoto, N, Inaba, S, Ogawa, S, Morii, H, Abe, R, Ito, N, Oda, M. 登録日 2018-09-06 公開日 2019-07-17 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural and functional properties of Grb2 SH2 dimer in CD28 binding. Biophys Physicobio., 16, 2019
6ICG	Grb2 SH2 domain in phosphopeptide free form 分子名称: GLYCEROL, Growth factor receptor-bound protein 2, SULFATE ION 著者 Hosoe, Y, Numoto, N, Inaba, S, Ogawa, S, Morii, H, Abe, R, Ito, N, Oda, M. 登録日 2018-09-06 公開日 2019-07-17 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 Structural and functional properties of Grb2 SH2 dimer in CD28 binding. Biophys Physicobio., 16, 2019
6HTF	Crystal structure of human Btk SH2 domain bound to rF10 repebody 分子名称: Tyrosine-protein kinase BTK, rF10 repebody 著者 Duarte, D.P, Pojer, F, Hantschel, O. 登録日 2018-10-04 公開日 2020-05-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.102 Å) 主引用文献 Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms. Nat Commun, 11, 2020
6I4X	Crystal structure of SOCS2:Elongin C:Elongin B in complex with erythropoietin receptor peptide 分子名称: DI(HYDROXYETHYL)ETHER, Elongin-B, Elongin-C, ... 著者 Kung, W.W, Ramachandran, S, Makukhin, N, Bruno, E, Ciulli, A. 登録日 2018-11-12 公開日 2019-05-29 最終更新日 2019-06-19 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase. Nat Commun, 10, 2019
6I5J	Crystal structure of SOCS2:Elongin C:Elongin B in complex with growth hormone receptor peptide 分子名称: COBALT (II) ION, Elongin-B, Elongin-C, ... 著者 Kung, W.W, Ramachandran, S, Makukhin, N, Bruno, E, Ciulli, A. 登録日 2018-11-13 公開日 2019-05-29 最終更新日 2019-11-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase. Nat Commun, 10, 2019
6I5N	Crystal structure of SOCS2:Elongin C:Elongin B in complex with growth hormone receptor peptide 分子名称: COBALT (II) ION, Elongin-B, Elongin-C, ... 著者 Kung, W.W, Ramachandran, S, Makukhin, N, Bruno, E, Ciulli, A. 登録日 2018-11-14 公開日 2019-05-29 最終更新日 2019-06-19 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase. Nat Commun, 10, 2019

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