PDB: 36667 件ウェブページステータス検索Chemie searchBIRD

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7Z5I	Transcription factor MYF5 bound to symmetrical site 分子名称: DNA (5'-D(P*AP*CP*GP*CP*GP*TP*CP*AP*GP*CP*TP*GP*AP*CP*GP*CP*GP*C)-3'), DNA (5'-D(P*GP*CP*GP*CP*GP*TP*CP*AP*GP*CP*TP*GP*AP*CP*GP*CP*GP*T)-3'), Myogenic factor 5 著者 Morgunova, E, Popov, A, Yin, Y, Taipale, J. 登録日 2022-03-09 公開日 2023-03-22 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Transcription factor MYF5 bound to symmetrical site To Be Published
7Z5K	Transcription factor MYF5 bound to non-symmetrical site 分子名称: DNA (5'-D(P*AP*CP*GP*CP*GP*TP*CP*AP*GP*CP*TP*GP*TP*TP*GP*CP*GP*C)-3'), DNA (5'-D(P*GP*CP*GP*CP*AP*AP*CP*AP*GP*CP*TP*GP*AP*CP*GP*CP*GP*T)-3'), Myogenic factor 5 著者 Morgunova, E, Popov, A, Yin, Y, Taipale, J. 登録日 2022-03-09 公開日 2023-03-22 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Transcription factor MYF5 bound to non-symmetrical site To Be Published
7Z5N	Crystal structure of DYRK1A in complex with CX-4945 分子名称: 1,2-ETHANEDIOL, 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid, DI(HYDROXYETHYL)ETHER, ... 著者 Pustelny, K, Grygier, P, Golik, P, Dubin, G, Czarna, A. 登録日 2022-03-09 公開日 2023-03-22 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.77 Å) 主引用文献 Crystal structure DYRK1A in complex with CX-4945 To Be Published
7Z5L	Crystal structure of human insulin, crystallised in the presence of macrophage migration inhibitory factor (MIF) and dimethyl sulfoxide (DMSO) 分子名称: GLYCEROL, Insulin A chain, Insulin B chain, ... 著者 van den Elsen, J.M.H, Wahid, A.A, Crennell, C. 登録日 2022-03-09 公開日 2023-03-22 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Dissociation of Hexameric Insulin Facilitated by Macrophage Migration Inhibitory Factor Indicates a Novel Role in Insulin Signalling To Be Published
7Z5Q	Crystal structure of human insulin, crystallised in the presence of macrophage migration inhibitory factor (MIF) and p-Hydroxyphenylpyruvate (HPP) 分子名称: Insulin, Insulin A chain, SULFATE ION 著者 van den Elsen, J.M.H, Wahid, A.A, Crennell, S.J. 登録日 2022-03-09 公開日 2023-03-22 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Dissociation of Hexameric Insulin Facilitated by Macrophage Migration Inhibitory Factor Indicates a Novel Role in Insulin Signalling To Be Published
7U8O	Structure of porcine V-ATPase with mEAK7 and SidK, Rotary state 2 分子名称: ATPase H(+)-transporting lysosomal accessory protein 2, ATPase H+ transporting accessory protein 1, Bacterial effector protein SidK, ... 著者 Tan, Y.Z, Keon, K.A. 登録日 2022-03-09 公開日 2022-07-06 最終更新日 2024-02-14 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 CryoEM of endogenous mammalian V-ATPase interacting with the TLDc protein mEAK-7. Life Sci Alliance, 5, 2022
7U8R	Structure of porcine kidney V-ATPase with SidK, Rotary State 3 分子名称: ADENOSINE-5'-DIPHOSPHATE, ATPase H(+)-transporting lysosomal accessory protein 2, ATPase H+ transporting accessory protein 1, ... 著者 Tan, Y.Z, Keon, K.A. 登録日 2022-03-09 公開日 2022-07-06 最終更新日 2024-02-14 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 CryoEM of endogenous mammalian V-ATPase interacting with the TLDc protein mEAK-7. Life Sci Alliance, 5, 2022
7U8P	Structure of porcine kidney V-ATPase with SidK, Rotary State 1 分子名称: ADENOSINE-5'-DIPHOSPHATE, ATPase H(+)-transporting lysosomal accessory protein 2, ATPase H+ transporting accessory protein 1, ... 著者 Tan, Y.Z, Keon, K.A. 登録日 2022-03-09 公開日 2022-07-06 最終更新日 2024-02-14 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 CryoEM of endogenous mammalian V-ATPase interacting with the TLDc protein mEAK-7. Life Sci Alliance, 5, 2022
7U8Q	Structure of porcine kidney V-ATPase with SidK, Rotary State 2 分子名称: ADENOSINE-5'-DIPHOSPHATE, ATPase H(+)-transporting lysosomal accessory protein 2, ATPase H+ transporting accessory protein 1, ... 著者 Tan, Y.Z, Keon, K.A. 登録日 2022-03-09 公開日 2022-07-06 最終更新日 2024-02-14 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 CryoEM of endogenous mammalian V-ATPase interacting with the TLDc protein mEAK-7. Life Sci Alliance, 5, 2022
7U8F	Ternary complex structure of Cereblon-DDB1 bound to IKZF2(ZF2) and the molecular glue DKY709 分子名称: (3S)-3-[5-(1-benzylpiperidin-4-yl)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DNA damage-binding protein 1, ... 著者 Ma, X, Ornelas, E, Clifton, M.C. 登録日 2022-03-08 公開日 2023-03-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy. Cell Chem Biol, 30, 2023
7U8K	Magic Angle Spinning NMR Structure of Human Cofilin-2 Assembled on Actin Filaments 分子名称: Actin, alpha skeletal muscle, Cofilin-2 著者 Kraus, J, Russell, R, Kudryashova, E, Xu, C, Katyal, N, Kudryashov, D, Perilla, J.R, Polenova, T. 登録日 2022-03-08 公開日 2023-08-16 最終更新日 2024-02-28 実験手法 SOLID-STATE NMR 主引用文献 Magic angle spinning NMR structure of human cofilin-2 assembled on actin filaments reveals isoform-specific conformation and binding mode. Nat Commun, 13, 2022
7U8H	Discovery of a KRAS G12V Inhibitor in vivo Tool Compound starting from an HSQC-NMR based Fragment Hit 分子名称: 1H-benzimidazol-2-ylmethanethiol, 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile, GTPase KRas, ... 著者 Phan, J, Fesik, S.W. 登録日 2022-03-08 公開日 2022-11-09 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.702 Å) 主引用文献 Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRAS G12C Inhibitor. J.Med.Chem., 65, 2022
7U71	Crystal Structure of Mouse Cadherin-23 EC13-15 分子名称: ACETATE ION, CALCIUM ION, Cadherin-23 著者 De La Torre, P, Sandhu, J.S, Velez-Cortes, F, Sotomayor, M. 登録日 2022-03-07 公開日 2023-03-15 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.975 Å) 主引用文献 Crystal Structure of Mouse Cadherin-23 EC13-15 To be published
7Z52	Human NEXT dimer - focused reconstruction of the single MTR4 分子名称: Exosome RNA helicase MTR4, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, RNA (5'-R(P*UP*UP*UP*UP*U)-3'), ... 著者 Gerlach, P, Lingaraju, M, Salerno-Kochan, A, Bonneau, F, Basquin, J, Conti, E. 登録日 2022-03-07 公開日 2022-06-22 最終更新日 2022-07-20 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome. Mol.Cell, 82, 2022
7U7N	IL-27 quaternary receptor signaling complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-27 receptor subunit alpha, ... 著者 Caveney, N.A, Glassman, C.R, Jude, K.M, Tsutsumi, N, Garcia, K.C. 登録日 2022-03-07 公開日 2022-05-25 実験手法 ELECTRON MICROSCOPY (3.47 Å) 主引用文献 Structure of the IL-27 quaternary receptor signaling complex. Elife, 11, 2022
7U7M	Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the presence of carbamazepine and ATP with Kir6.2-CTD in the up conformation 分子名称: ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ATP-sensitive inward rectifier potassium channel 11 著者 Shyng, S.L, Sung, M.W, Driggers, C.M. 登録日 2022-03-07 公開日 2022-08-31 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (5.2 Å) 主引用文献 Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel. J.Mol.Biol., 434, 2022
7X6I	Cryo-EM structure of the human TRPC5 ion channel in complex with G alpha i3 subunits, class1 分子名称: (2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... 著者 Won, J, Jeong, H, Lee, H.H. 登録日 2022-03-07 公開日 2023-04-26 最終更新日 2023-05-24 実験手法 ELECTRON MICROSCOPY (3.93 Å) 主引用文献 Molecular architecture of the G alpha i -bound TRPC5 ion channel. Nat Commun, 14, 2023
7X6C	Cryo-EM structure of the human TRPC5 ion channel in lipid nanodiscs, class1 分子名称: (2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, ... 著者 Won, J, Jeong, H, Lee, H.H. 登録日 2022-03-07 公開日 2023-05-24 実験手法 ELECTRON MICROSCOPY (3.15 Å) 主引用文献 Molecular architecture of the G alpha i -bound TRPC5 ion channel. Nat Commun, 14, 2023
7Z4Z	Human NEXT dimer - focused reconstruction of the dimerization module 分子名称: Exosome RNA helicase MTR4, Zinc finger CCHC domain-containing protein 8 著者 Gerlach, P, Lingaraju, M, Salerno-Kochan, A, Bonneau, F, Basquin, J, Conti, E. 登録日 2022-03-06 公開日 2022-06-22 最終更新日 2022-07-20 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome. Mol.Cell, 82, 2022
7Z4Y	Human NEXT dimer - overall reconstruction of the core complex 分子名称: Exosome RNA helicase MTR4, Zinc finger CCHC domain-containing protein 8 著者 Gerlach, P, Lingaraju, M, Salerno-Kochan, A, Bonneau, F, Basquin, J, Conti, E. 登録日 2022-03-06 公開日 2022-06-22 最終更新日 2022-07-20 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome. Mol.Cell, 82, 2022
7U6Y	Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the presence of glibenclamide and ATP with Kir6.2-CTD in the down conformation 分子名称: ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ATP-sensitive inward rectifier potassium channel 11 著者 Shyng, S.L, Sung, M.W, Driggers, C.M. 登録日 2022-03-06 公開日 2022-08-31 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (7.4 Å) 主引用文献 Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel. J.Mol.Biol., 434, 2022
7Z4V	Structure of Serine-Threonine kinase STK25 in complex with compound 分子名称: 1,2-ETHANEDIOL, Serine/threonine-protein kinase 25, ~{N}-(5-~{tert}-butyl-1~{H}-pyrazol-3-yl)-4-pyrrolidin-1-ylsulfonyl-benzamide 著者 Nawrotek, A, Vuillard, L, Miallau, L. 登録日 2022-03-04 公開日 2022-04-06 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.644 Å) 主引用文献 Targeting non-alcoholic fatty liver disease: Design, X-ray co-crystal structure and synthesis of 'first-in-kind' inhibitors of serine/threonine kinase25. Bioorg.Med.Chem.Lett., 75, 2022
7X5H	Serotonin 5A (5-HT5A) receptor-Gi protein complex 分子名称: 3-(2-azanylethyl)-1H-indole-5-carboxamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Tan, Y, Xu, P, Huang, S, Xu, H.E, Jiang, Y. 登録日 2022-03-04 公開日 2022-09-14 最終更新日 2022-09-21 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural insights into the ligand binding and G i coupling of serotonin receptor 5-HT 5A . Cell Discov, 8, 2022
7X5B	Crystal structure of RuvB 分子名称: ADENOSINE-5'-DIPHOSPHATE, Holliday junction ATP-dependent DNA helicase RuvB 著者 Lin, Z, Qu, Q, Zhang, X, Zhou, Z, Dai, L. 登録日 2022-03-04 公開日 2023-03-08 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.16 Å) 主引用文献 Cryo-EM structure of the RuvAB-Holliday junction intermediate complex from Pseudomonas aeruginosa. Front Plant Sci, 14, 2023
7U5Z	Crystal Structure of HIV-1 Reverse Transcriptase in Complex with JLJ353 分子名称: 2-chloro-4-({5-[(2,6-difluorophenyl)methyl]-1,3-oxazol-2-yl}amino)benzonitrile, Reverse transcriptase/ribonuclease H, p51 RT 著者 Hollander, K, Carter, Z, Jorgensen, W.L, Anderson, K.S. 登録日 2022-03-03 公開日 2023-03-15 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Design, synthesis, and biological testing of biphenylmethyloxazole inhibitors targeting HIV-1 reverse transcriptase. Bioorg.Med.Chem.Lett., 84, 2023

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