7U5Z

Crystal Structure of HIV-1 Reverse Transcriptase in Complex with JLJ353

Summary for 7U5Z

Entry DOI	10.2210/pdb7u5z/pdb
Descriptor	Reverse transcriptase/ribonuclease H, p51 RT, 2-chloro-4-({5-[(2,6-difluorophenyl)methyl]-1,3-oxazol-2-yl}amino)benzonitrile, ... (4 entities in total)
Functional Keywords	reverse transcriptase, antiviral, drug design, viral protein, hiv-1
Biological source	Human immunodeficiency virus type 1 BH10 More
Total number of polymer chains	2
Total formula weight	114374.46
Authors	Hollander, K.,Carter, Z.,Jorgensen, W.L.,Anderson, K.S. (deposition date: 2022-03-03, release date: 2023-03-15, Last modification date: 2023-10-25)
Primary citation	Carter, Z.J.,Hollander, K.,Spasov, K.A.,Anderson, K.S.,Jorgensen, W.L. Design, synthesis, and biological testing of biphenylmethyloxazole inhibitors targeting HIV-1 reverse transcriptase. Bioorg.Med.Chem.Lett., 84:129216-129216, 2023 Cited by PubMed: 36871704 DOI: 10.1016/j.bmcl.2023.129216 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation