PDB: 222415 件ウェブページステータス検索Chemie searchBIRD

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8XAI	Crystal structure of Protease CPAVM1 in Bacillus subtilis LjM2 分子名称: Lipoprotein 著者 Zhang, J, Wang, C.Y. 登録日 2023-12-04 公開日 2024-06-19 最終更新日 2024-07-10 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Anti-influenza activity of CPAVM1 protease secreted by Bacillus subtilis LjM2. Antiviral Res., 228, 2024
7LFV	Crystal structure of the SARS CoV-1 Papain-like protease in complex with peptide inhibitor VIR251 分子名称: 1,2-ETHANEDIOL, AMMONIUM ION, CHLORIDE ION, ... 著者 Olsen, S.K, Lv, Z. 登録日 2021-01-18 公開日 2021-11-10 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease. Cell Rep, 36, 2021
6DOP	Crystal Structure of Bacillus Halodurans Ribonuclease H1 in Complex with an RNA/DNA Hybrid: Reaction in 2 mM Mg2+ and 200 mM K+ for 120 s at 21 C (dataset 1) 分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*CP*GP*AP*TP*GP*T)-3'), GLYCEROL, ... 著者 Samara, N.L, Yang, W. 登録日 2018-06-09 公開日 2018-08-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Cation trafficking propels RNA hydrolysis. Nat. Struct. Mol. Biol., 25, 2018
7LFU	Crystal structure of the SARS CoV-1 Papain-like protease in complex with peptide inhibitor VIR250 分子名称: Papain-like protease peptide inhibitor VIR250, papain-like protease 著者 Olsen, S.K, Lv, Z. 登録日 2021-01-18 公開日 2021-11-10 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease. Cell Rep, 36, 2021
1M3I	Perfringolysin O, new crystal form 分子名称: perfringolysin O 著者 Rossjohn, J, Parker, M, Polekhina, G, Feil, S, Tweten, R. 登録日 2002-06-28 公開日 2004-02-03 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural Snapshots in the Molecular Mechanism of PFO Revealed To be Published
8XH7	Structure of EBV LMP1 oligomer 分子名称: Latent membrane protein 1 著者 Gao, P, Huang, J.F. 登録日 2023-12-17 公開日 2024-06-26 実験手法 ELECTRON MICROSCOPY (3.52 Å) 主引用文献 Assembly and activation of EBV latent membrane protein 1 To Be Published
8YF1	Cryo-EM structure of human SV2A in complex with Brivaracetam 分子名称: (2S)-2-[(4R)-2-oxidanylidene-4-propyl-pyrrolidin-1-yl]butanamide, Synaptic vesicle glycoprotein 2A 著者 Qu, Q, Liu, S, Zhou, Z. 登録日 2024-02-23 公開日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.38 Å) 主引用文献 Cryo-EM structure of human SV2A in complex with Brivaracetam To Be Published
6DPK	Crystal Structure of Bacillus Halodurans Ribonuclease H1 K196A in Complex with an RNA/DNA Hybrid: Reaction in 4 mM Mn2+ and 200 mM K+ for 240 s at 21 C 分子名称: 1,2-ETHANEDIOL, 5'-R(*AP*CP*AP*U)-3' portion of cleaved RNA 5'-R(*AP*CP*AP*UP*CP*G)-3', 5'-R(P*CP*G)-3' portion of cleaved RNA (5'-R(*AP*CP*AP*UP*CP*G)-3'), ... 著者 Samara, N.L, Yang, W. 登録日 2018-06-09 公開日 2018-08-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.391 Å) 主引用文献 Cation trafficking propels RNA hydrolysis. Nat. Struct. Mol. Biol., 25, 2018
8ZH5	The Crystal Structure of the ROCK1 from Biortus. 分子名称: Rho-associated protein kinase 1 著者 Wang, F, Cheng, W, Yuan, Z, Lin, D, Wang, J. 登録日 2024-05-10 公開日 2024-06-26 実験手法 X-RAY DIFFRACTION (3.7 Å) 主引用文献 The Crystal Structure of the ROCK1 from Biortus. To Be Published
8ZM2	Structure of human pyruvate dehydrogenase kinase 2 complexed with compound 16 分子名称: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial, methyl (9~{R})-9-oxidanyl-9-(trifluoromethyl)fluorene-4-carboxylate 著者 Akai, S, Orita, T, Nomura, A, Adachi, T. 登録日 2024-05-22 公開日 2024-06-19 最終更新日 2024-07-03 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Design and synthesis of novel fluorene derivatives as inhibitors of pyruvate dehydrogenase kinase. Bioorg.Med.Chem.Lett., 109, 2024
9BFY	Tri-complex of Compound-12, KRAS G12C, and CypA 分子名称: (3R)-N-[(2S)-1-{[(1M,8R,10R,14S,21M)-22-ethyl-4-hydroxy-21-{2-[(1R)-1-methoxyethyl]pyridin-3-yl}-18,18-dimethyl-9,15-dioxo-16-oxa-10,22,28-triazapentacyclo[18.5.2.1~2,6~.1~10,14~.0~23,27~]nonacosa-1(25),2(29),3,5,20,23,26-heptaen-8-yl]amino}-3-methyl-1-oxobutan-2-yl]-N-methyl-1-propanoylpyrrolidine-3-carboxamide (non-preferred name), CHLORIDE ION, GTPase KRas, ... 著者 Tomlinson, A.C.A, Saldajeno-Concar, M, Knox, J.E, Yano, J.K. 登録日 2024-04-18 公開日 2024-06-12 最終更新日 2024-06-26 実験手法 X-RAY DIFFRACTION (1.26 Å) 主引用文献 Tri-complex of Compound-12, KRAS G12C, and CypA To be published
8ZQ3	Structure of ORP1L-RAB7A in the presence of GDP 分子名称: GUANOSINE-5'-DIPHOSPHATE, Oxysterol-binding protein-related protein 1, Ras-related protein Rab-7a 著者 Lu, Q, Zhang, J, Xu, C. 登録日 2024-05-31 公開日 2024-06-26 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 Structure of GDP-bound Rab7 Q67L in complex with ORP1L. Biochem.Biophys.Res.Commun., 725, 2024
9B8Q	Synaptic Vesicle V-ATPase with synaptophysin and SidK, State 3, peripheral stalks 分子名称: V-type proton ATPase 116 kDa subunit a isoform 1, V-type proton ATPase subunit C 1, V-type proton ATPase subunit E 1, ... 著者 Coupland, C.E, Rubinstein, J.L. 登録日 2024-03-31 公開日 2024-06-26 最終更新日 2024-07-03 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 High-resolution electron cryomicroscopy of V-ATPase in native synaptic vesicles. Science, 2024
7LXH	Bacillus cereus DNA glycosylase AlkD bound to a CC1065-adenine nucleobase adduct and DNA containing an abasic site 分子名称: 7-{7-[(1R)-1-{[(4P)-6-amino-3H-purin-3-yl]methyl}-5-hydroxy-8-methyl-1,6-dihydropyrrolo[3,2-e]indole-3(2H)-carbonyl]-4-hydroxy-5-methoxy-1,6-dihydropyrrolo[3,2-e]indole-3(2H)-carbonyl}-4-hydroxy-5-methoxy-1,6-dihydropyrrolo[3,2-e]indole-3(2H)-carboxamide, CALCIUM ION, DNA (5'-D(*AP*GP*CP*AP*AP*(ORP)P*GP*GP*C)-3'), ... 著者 Mullins, E.A, Eichman, B.F. 登録日 2021-03-03 公開日 2021-11-17 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.667 Å) 主引用文献 Structural evolution of a DNA repair self-resistance mechanism targeting genotoxic secondary metabolites. Nat Commun, 12, 2021
9EUD	The FK1 domain of FKBP51 in complex with SAFit-analog 23c 分子名称: (1-propan-2-ylpyrazol-4-yl)methyl (2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)ethanoyl]piperidine-2-carboxylate, Peptidyl-prolyl cis-trans isomerase FKBP5 著者 Meyners, C, Buffa, V, Hausch, F. 登録日 2024-03-27 公開日 2024-06-12 実験手法 X-RAY DIFFRACTION (2.022 Å) 主引用文献 1,4-Pyrazolyl-containing SAFit-analogues are selective FKBP51 inhibitors with improved ligand efficiency and drug-like profile. Chemmedchem, 2024
9C0Z	Clathrin terminal domain complexed with pitstop 2d 分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, ... 著者 Bulut, H, Horatscheck, A, Krauss, M, Santos, K.F, McCluskey, A, Wahl, C.W, Nazare, M, Haucke, V. 登録日 2024-05-28 公開日 2024-06-26 実験手法 X-RAY DIFFRACTION (1.51 Å) 主引用文献 Acute inhibition of clathrin-mediated endocytosis by next-generation small molecule inhibitors of clathrin function To Be Published
9EY4	The FK1 domain of FKBP51 in complex with (3S,11S)-12-((3,5-dichlorophenyl)sulfonyl)-5-oxo-11-vinyldecahydro-1H-6,10-epiminopyrrolo[1,2-a]azonine-3-carboxamide 分子名称: (1~{S},4~{S},7~{S},8~{S},9~{R})-13-[3,5-bis(chloranyl)phenyl]sulfonyl-8-ethenyl-2-oxidanylidene-3,13-diazatricyclo[7.3.1.0^{3,7}]tridecane-4-carboxamide, Peptidyl-prolyl cis-trans isomerase FKBP5 著者 Meyners, C, Krajczy, P, Hausch, F. 登録日 2024-04-09 公開日 2024-06-12 実験手法 X-RAY DIFFRACTION (1.16 Å) 主引用文献 Structure-Based Design of Ultrapotent Tricyclic Ligands for FK506-Binding proteins. Chemistry, 2024
8XZD	The structure of fox ACE2 and Omicron BF.7 RBD complex 分子名称: Angiotensin-converting enzyme, Spike protein S1, ZINC ION 著者 sun, J.Q. 登録日 2024-01-21 公開日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.47 Å) 主引用文献 The structure of fox ACE2 and Omicron BF.7 RBD complex To Be Published
8YF0	Cryo-EM structure of human SV2A 分子名称: Synaptic vesicle glycoprotein 2A 著者 Qu, Q, Liu, S, Zhou, Z. 登録日 2024-02-23 公開日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.49 Å) 主引用文献 Cryo-EM structure of human SV2A To Be Published
8YAX	SARS-CoV-2 DMV nsp3-4 pore complex (full-pore) 分子名称: Non-structural protein 4, Papain-like protease nsp3 著者 Huang, Y.X, Zhong, L.J, Zhang, W.X, Ni, T. 登録日 2024-02-10 公開日 2024-06-19 実験手法 ELECTRON MICROSCOPY (4.9 Å) 主引用文献 Molecular Architecture of Coronavirus Double Membrane Vesicle Pore Complex To Be Published
9BBG	Co-crystal structure of human DDB1 bound to fragment UB028671 分子名称: 1,2-ETHANEDIOL, 1H-indol-6-amine, DNA damage-binding protein 1, ... 著者 Zeng, H, Dong, A, Frommlet, A, Seitova, A, Loppnau, P, Ackloo, S, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) 登録日 2024-04-05 公開日 2024-06-12 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Co-crystal structure of human DDB1 bound to fragment UB028671 To be published
7LXJ	Bacillus cereus DNA glycosylase AlkD bound to a duocarmycin SA-adenine nucleobase adduct and DNA containing an abasic site 分子名称: CALCIUM ION, DNA (5'-D(*AP*GP*CP*AP*AP*(ORP)P*GP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*CP*TP*TP*TP*GP*C)-3'), ... 著者 Mullins, E.A, Eichman, B.F. 登録日 2021-03-03 公開日 2021-11-17 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Structural evolution of a DNA repair self-resistance mechanism targeting genotoxic secondary metabolites. Nat Commun, 12, 2021
2G0A	X-ray structure of mouse pyrimidine 5'-nucleotidase type 1 with lead(II) bound in active site 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Cytosolic 5'-nucleotidase III, LEAD (II) ION 著者 Bitto, E, Bingman, C.A, Wesenberg, G.E, Phillips Jr, G.N, Center for Eukaryotic Structural Genomics (CESG) 登録日 2006-02-11 公開日 2006-04-04 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structure of pyrimidine 5'-nucleotidase type 1. Insight into mechanism of action and inhibition during lead poisoning. J.Biol.Chem., 281, 2006
9EP1	Structure of the Integrator arm module containing INTS10/13/14/15 subunits (state 2) 分子名称: Integrator complex subunit 10, Integrator complex subunit 13, Integrator complex subunit 14, ... 著者 Razew, M, Galej, W.P. 登録日 2024-03-16 公開日 2024-06-12 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structural basis of the Integrator complex assembly and association with transcription factors. Mol.Cell, 2024
8ZNE	Cryo-EM structure of W89F mutated Glutamate dehydrogenase from Thermococcus profundus in complex with NADP and GLU in the steady stage of reaction 分子名称: GLUTAMIC ACID, Glutamate dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Wakabayashi, T, Nakasako, M. 登録日 2024-05-26 公開日 2024-06-26 実験手法 ELECTRON MICROSCOPY (2.64 Å) 主引用文献 Mechanism for drastic reduction in catalytic activity of Trp89Phe-mutated glutamate dehydrogenase revealed by cryoEM-sampling metastable conformation in action To Be Published

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