PDB: 13252 件ウェブページステータス検索Chemie searchBIRD

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7Z77	Crystal structure of compound 6 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB 分子名称: (2~{S},4~{R})-~{N}-[(1~{S})-4-[4-(4-bromanyl-7-cyclopentyl-5-oxidanylidene-benzimidazolo[1,2-a]quinazolin-9-yl)piperidin-1-yl]-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]butyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... 著者 Bader, G, Boettcher, J, Wolkerstorfer, B. 登録日 2022-03-15 公開日 2022-09-14 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo. Nat Commun, 13, 2022
7Z76	Crystal structure of compound 10 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB 分子名称: (2~{S},4~{R})-~{N}-[(1~{R})-2-[(2~{R})-1-[4-(4-bromanyl-7-cyclopentyl-5-oxidanylidene-benzimidazolo[1,2-a]quinazolin-9-yl)piperidin-1-yl]propan-2-yl]oxy-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]-1-[(2~{S})-2-[[1-(dimethylamino)cyclopropyl]carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... 著者 Bader, G, Boettcher, J, Wolkerstorfer, B. 登録日 2022-03-15 公開日 2022-09-14 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.32 Å) 主引用文献 A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo. Nat Commun, 13, 2022
6EIH	The crystal structure of 14-3-3 epsilon in complex with the phosphorylated NELFE peptide 分子名称: 14-3-3 protein epsilon, SER-ILE-SEP-ARG 著者 Akutsu, M, Wagner, S.A, Beli, P. 登録日 2017-09-19 公開日 2018-02-14 最終更新日 2019-10-16 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage. Nat Commun, 9, 2018
2P3O	Crystal Structure of Dengue Methyltransferase in Complex with 7MeGpppA and S-Adenosyl-L-homocysteine 分子名称: CITRIC ACID, P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Egloff, M.P, Marseilles Structural Genomics Program @ AFMB (MSGP) 登録日 2007-03-09 公開日 2007-08-28 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.756 Å) 主引用文献 Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5 J.Mol.Biol., 372, 2007
5IP2	Tomato spotted wilt tospovirus nucleocapsid protein-ssRNA complex 分子名称: Nucleoprotein, RNA (5'-D(P*UP*UP*U)-3'), RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 著者 Komoda, K, Narita, M, Yamashita, K, Tanaka, I, Yao, M. 登録日 2016-03-09 公開日 2017-03-22 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Asymmetric Trimeric Ring Structure of the Nucleocapsid Protein of Tospovirus. J. Virol., 91, 2017
5AN4	Crystal structure of the human 8-oxoguanine glycosylase (OGG1) processed with the CrystalDirect automated mounting and cryo-cooling technology 分子名称: N-GLYCOSYLASE/DNA LYASE, SULFATE ION 著者 Zander, U, Ytre-Arne, M, Dalhus, B, Hoffmann, G, Cornaciu, I, Cipriani, F, Marquez, J.A. 登録日 2015-09-04 公開日 2016-04-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Automated Harvesting and Processing of Protein Crystals Through Laser Photoablation. Acta Crystallogr.,Sect.D, 72, 2016
8Q1N	Cyclic peptide binder of the WBM-site of WDR5 分子名称: Cyclic peptide inhibitor, WD repeat-containing protein 5 著者 Schmeing, S, Chang, J.Y, t Hart, P, Gasper, R. 登録日 2023-08-01 公開日 2023-09-06 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.843 Å) 主引用文献 Macrocyclic peptides as inhibitors of WDR5-lncRNA interactions. Chem.Commun.(Camb.), 59, 2023
2P41	Crystal Structure of Dengue Methyltransferase in Complex with 7MeGpppG2'OMe and S-Adenosyl-L-homocysteine 分子名称: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-(2'-O-METHYL)-GUANOSINE, CITRIC ACID, GLYCEROL, ... 著者 Egloff, M.P, Marseilles Structural Genomics Program @ AFMB (MSGP) 登録日 2007-03-11 公開日 2007-08-28 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.801 Å) 主引用文献 Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5 J.Mol.Biol., 372, 2007
2P3Q	Crystal Structure of Dengue Methyltransferase in Complex with GpppG and S-Adenosyl-L-homocysteine 分子名称: DIGUANOSINE-5'-TRIPHOSPHATE, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... 著者 Egloff, M.P, Marseilles Structural Genomics Program @ AFMB (MSGP) 登録日 2007-03-09 公開日 2007-08-28 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5 J.Mol.Biol., 372, 2007
6DCZ	The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 3-hydroxy-4-oxo-4H-pyran-2-carboxylic acid 分子名称: 3-hydroxy-4-oxo-4H-pyran-2-carboxylic acid, MANGANESE (II) ION, Polymerase acidic protein 著者 Dick, B.L, Morrison, C.N, Cohen, S.M. 登録日 2018-05-08 公開日 2018-11-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 Structure-Activity Relationships in Metal-Binding Pharmacophores for Influenza Endonuclease. J. Med. Chem., 61, 2018
6DCY	The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 5-hydroxy-2-methyl-4-oxo-4H-pyran-3-carboxylic acid 分子名称: 5-hydroxy-2-methyl-4-oxo-4H-pyran-3-carboxylic acid, MANGANESE (II) ION, Polymerase acidic protein 著者 Dick, B.L, Morrison, C.N, Cohen, S.M. 登録日 2018-05-08 公開日 2018-11-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Structure-Activity Relationships in Metal-Binding Pharmacophores for Influenza Endonuclease. J. Med. Chem., 61, 2018
2JLS	Dengue virus 4 NS3 helicase in complex with ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, BETA-MERCAPTOETHANOL, CHLORIDE ION, ... 著者 Luo, D.H, Xu, T, Watson, R.P, Becker, D.S, Sampath, A, Jahnke, W, Yeong, S.S, Wang, C.H, Lim, S.P, Vasudevan, S.G, Lescar, J. 登録日 2008-09-15 公開日 2008-11-25 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Insights Into RNA Unwinding and ATP Hydrolysis by the Flavivirus Ns3 Protein. Embo J., 27, 2008
8DVR	Cryo-EM structure of RIG-I bound to the end of p3SLR30 (+AMPPNP) 分子名称: Antiviral innate immune response receptor RIG-I, GUANOSINE-5'-TRIPHOSPHATE, ZINC ION, ... 著者 Wang, W, Pyle, A.M. 登録日 2022-07-29 公開日 2022-11-02 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands. Mol.Cell, 82, 2022
8DVS	Cryo-EM structure of RIG-I bound to the end of OHSLR30 (+ATP) 分子名称: ADENOSINE-5'-DIPHOSPHATE, Antiviral innate immune response receptor RIG-I, MAGNESIUM ION, ... 著者 Wang, W, Pyle, A.M. 登録日 2022-07-29 公開日 2022-11-16 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands. Mol.Cell, 82, 2022
6E0Q	The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 4,6-dihydroxy-2-methyl-5-oxocyclohepta-1,3,6-triene-1-carboxylic acid 分子名称: 1,2-ETHANEDIOL, 4,6-dihydroxy-2-methyl-5-oxocyclohepta-1,3,6-triene-1-carboxylic acid, MANGANESE (II) ION, ... 著者 Dick, B.L, Morrison, C.N, Cohen, S.M. 登録日 2018-07-06 公開日 2018-11-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structure-Activity Relationships in Metal-Binding Pharmacophores for Influenza Endonuclease. J. Med. Chem., 61, 2018
2JLR	Dengue virus 4 NS3 helicase in complex with AMPPNP 分子名称: MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SERINE PROTEASE SUBUNIT NS3 著者 Luo, D.H, Xu, T, Watson, R.P, Becker, D.S, Sampath, A, Jahnke, W, Yeong, S.S, Wang, C.H, Lim, S.P, Vasudevan, S.G, Lescar, J. 登録日 2008-09-15 公開日 2008-11-25 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Insights Into RNA Unwinding and ATP Hydrolysis by the Flavivirus Ns3 Protein. Embo J., 27, 2008
2JLQ	Dengue virus 4 NS3 helicase structure, apo enzyme. 分子名称: CHLORIDE ION, GLYCEROL, SERINE PROTEASE SUBUNIT NS3 著者 Luo, D.H, Xu, T, Watson, R.P, Becker, D.S, Sampath, A, Jahnke, W, Yeong, S.S, Wang, C.H, Lim, S.P, Vasudevan, S.G, Lescar, J. 登録日 2008-09-15 公開日 2008-11-25 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Insights Into RNA Unwinding and ATP Hydrolysis by the Flavivirus Ns3 Protein. Embo J., 27, 2008
7DE9	crystal structure of Arabidopsis RDM15 tudor domain in complex with an H3K4me1 peptide 分子名称: Histone H3.2, Transcriptional regulator 著者 Song, Z, Du, J. 登録日 2020-11-03 公開日 2021-04-07 最終更新日 2021-06-23 実験手法 X-RAY DIFFRACTION (1.711 Å) 主引用文献 A histone H3K4me1-specific binding protein is required for siRNA accumulation and DNA methylation at a subset of loci targeted by RNA-directed DNA methylation. Nat Commun, 12, 2021
6DZQ	The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic acid 分子名称: 1,2-ETHANEDIOL, 3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic acid, MANGANESE (II) ION, ... 著者 Dick, B.L, Morrison, C.N, Cohen, S.M. 登録日 2018-07-05 公開日 2018-11-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structure-Activity Relationships in Metal-Binding Pharmacophores for Influenza Endonuclease. J. Med. Chem., 61, 2018
2JZB	Solution structure of the complex between E.coli NusA-AR2 and RNAP-aCTD 分子名称: DNA-directed RNA polymerase subunit alpha, Transcription elongation protein nusA 著者 Prasch, S, Schweimer, K, Roesch, P. 登録日 2008-01-02 公開日 2009-04-28 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 structural basis of transcription elongation control: the NusA-aCTD complex To be Published
2WJ8	Respiratory Syncitial Virus RiboNucleoProtein 分子名称: BORATE ION, NUCLEOPROTEIN, RNA (5'-R(*CP*CP*CP*CP*CP*C)-3') 著者 Tawar, R.G, Duquerroy, S, Vonrhein, C, Varela, P.F, Damier-Piolle, L, Castagne, N, MacLellan, K, Bedouelle, H, Bricogne, G, Bhella, D, Eleouet, J, Rey, F.A. 登録日 2009-05-25 公開日 2009-12-08 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (3.29 Å) 主引用文献 Crystal Structure of a Nucleocapsid-Like Nucleoprotein-RNA Complex of Respiratory Syncytial Virus Science, 326, 2009
2HOK	Crystal structure of an E. coli thi-box riboswitch bound to thiamine pyrophosphate, calcium ions 分子名称: CALCIUM ION, THIAMINE DIPHOSPHATE, thi-box riboswitch 著者 Edwards, T.E, Ferre-D'Amare, A.R. 登録日 2006-07-14 公開日 2006-09-19 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Crystal Structures of the Thi-Box Riboswitch Bound to Thiamine Pyrophosphate Analogs Reveal Adaptive RNA-Small Molecule Recognition Structure, 14, 2006
2HOM	Crystal structure of an E. coli thi-box riboswitch bound to thiamine monophosphate 分子名称: CALCIUM ION, MAGNESIUM ION, THIAMIN PHOSPHATE, ... 著者 Edwards, T.E, Ferre-D'Amare, A.R. 登録日 2006-07-14 公開日 2006-09-19 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 Crystal Structures of the Thi-Box Riboswitch Bound to Thiamine Pyrophosphate Analogs Reveal Adaptive RNA-Small Molecule Recognition Structure, 14, 2006
2HOL	Crystal structure of an E. coli thi-box riboswitch bound to thiamine pyrophosphate, barium ions 分子名称: BARIUM ION, CALCIUM ION, MAGNESIUM ION, ... 著者 Edwards, T.E, Ferre-D'Amare, A.R. 登録日 2006-07-14 公開日 2006-09-19 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal Structures of the Thi-Box Riboswitch Bound to Thiamine Pyrophosphate Analogs Reveal Adaptive RNA-Small Molecule Recognition Structure, 14, 2006
2HOJ	Crystal structure of an E. coli thi-box riboswitch bound to thiamine pyrophosphate, manganese ions 分子名称: MAGNESIUM ION, MANGANESE (II) ION, THIAMINE DIPHOSPHATE, ... 著者 Edwards, T.E, Ferre-D'Amare, A.R. 登録日 2006-07-14 公開日 2006-09-19 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal Structures of the Thi-Box Riboswitch Bound to Thiamine Pyrophosphate Analogs Reveal Adaptive RNA-Small Molecule Recognition Structure, 14, 2006

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