8GAU
 
 | | Structure of human NDS.1 Fab and 1G01 Fab in complex with influenza virus neuraminidase from A/Indiana/10/2011 (H3N2v) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 1G01, heavy chain, ... | | 著者 | Tsybovsky, Y, Lederhofer, J, Kwong, P.D, Kanekiyo, M. | | 登録日 | 2023-02-23 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase.
Immunity, 57, 2024
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8GAT
 | | Structure of human NDS.1 Fab and 1G01 Fab in complex with influenza virus neuraminidase from A/Indiana/10/2011 (H3N2v), based on consensus cryo-EM map with only Fab 1G01 resolved | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 1G01, heavy chain, ... | | 著者 | Tsybovsky, Y, Lederhofer, J, Kwong, P.D, Kanekiyo, M. | | 登録日 | 2023-02-23 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase.
Immunity, 57, 2024
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8GAS
 | | vFP48.02 Fab in complex with BG505 DS-SOSIP Env trimer | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... | | 著者 | Gorman, J, Kwong, P.D. | | 登録日 | 2023-02-23 | | 公開日 | 2023-04-19 | | 最終更新日 | 2023-06-14 | | 実験手法 | ELECTRON MICROSCOPY (4.04 Å) | | 主引用文献 | Diverse Murine Vaccinations Reveal Distinct Antibody Classes to Target Fusion Peptide and Variation in Peptide Length to Improve HIV Neutralization.
J.Virol., 97, 2023
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8GAL
 | | Crystal Structure of the E. coli LptA in complex with Murgantia histrionica Thanatin | | 分子名称: | Lipopolysaccharide export system protein LptA, Thanatin | | 著者 | Kibrom, A, Huynh, K, Donald, B, Zhou, P. | | 登録日 | 2023-02-23 | | 公開日 | 2023-07-19 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Discovery, characterization, and redesign of potent antimicrobial thanatin orthologs from Chinavia ubica and Murgantia histrionica targeting E. coli LptA.
J Struct Biol X, 8, 2023
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8GAG
 | | Cannabinoid receptor 1-Gi complex with novel ligand | | 分子名称: | Cannabinoid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Tummino, T.A, Iliopoulos-Tsoutsouvas, C, Braz, J.M, O'Brien, E.S, Krishna Kumar, K, Makriyannis, M, Basbaum, A.I, Shoichet, B.K. | | 登録日 | 2023-02-22 | | 公開日 | 2024-02-28 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Cannabinoid receptor 1-Gi complex with novel ligand
To Be Published
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8GA8
 | | Structure of the yeast (HDAC) Rpd3L complex | | 分子名称: | Histone deacetylase RPD3, Transcriptional regulatory protein DEP1, Transcriptional regulatory protein PHO23, ... | | 著者 | Patel, A.B, Radhakrishnan, I, He, Y. | | 登録日 | 2023-02-22 | | 公開日 | 2023-07-12 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Cryo-EM structure of the Saccharomyces cerevisiae Rpd3L histone deacetylase complex.
Nat Commun, 14, 2023
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8GA7
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8GA6
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8GA2
 | | Bromodomain of CBP liganded with inhibitor iCBP5 | | 分子名称: | (6S)-6-{(5M)-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(1s,4R)-4-methoxycyclohexyl]-1H-benzimidazol-2-yl}-1-phenylpiperidin-2-one, 1,2-ETHANEDIOL, CREB-binding protein | | 著者 | Schonbrunn, E, Bikowitz, M. | | 登録日 | 2023-02-22 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition.
Nat Commun, 15, 2024
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8G9Z
 | | High-resolution crystal structure of the human selenomethionine-derived SepSecS-tRNASec complex | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, O-phosphoseryl-tRNA(Sec) selenium transferase, ... | | 著者 | Puppala, A, Simonovic, M, Castillo Suchkou, J. | | 登録日 | 2023-02-22 | | 公開日 | 2023-04-05 | | 最終更新日 | 2023-05-17 | | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | | 主引用文献 | Structural basis for the tRNA-dependent activation of the terminal complex of selenocysteine synthesis in humans.
Nucleic Acids Res., 51, 2023
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8G9Y
 | | Cryo-EM structure of vFP49.02 Fab in complex with HIV-1 Env BG505 DS-SOSIP.664 (conformation 3) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... | | 著者 | Changela, A, Gorman, J, Kwong, P.D. | | 登録日 | 2023-02-22 | | 公開日 | 2023-04-19 | | 最終更新日 | 2023-06-14 | | 実験手法 | ELECTRON MICROSCOPY (4.28 Å) | | 主引用文献 | Diverse Murine Vaccinations Reveal Distinct Antibody Classes to Target Fusion Peptide and Variation in Peptide Length to Improve HIV Neutralization.
J.Virol., 97, 2023
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8G9X
 | | Cryo-EM structure of vFP49.02 Fab in complex with HIV-1 Env BG505 DS-SOSIP.664 (conformation 2) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... | | 著者 | Changela, A, Gorman, J, Kwong, P.D. | | 登録日 | 2023-02-22 | | 公開日 | 2023-04-19 | | 最終更新日 | 2023-06-14 | | 実験手法 | ELECTRON MICROSCOPY (4.46 Å) | | 主引用文献 | Diverse Murine Vaccinations Reveal Distinct Antibody Classes to Target Fusion Peptide and Variation in Peptide Length to Improve HIV Neutralization.
J.Virol., 97, 2023
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8G9W
 | | Cryo-EM structure of vFP49.02 Fab in complex with HIV-1 Env BG505 DS-SOSIP.664 (conformation 1) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... | | 著者 | Changela, A, Gorman, J, Kwong, P.D. | | 登録日 | 2023-02-22 | | 公開日 | 2023-04-19 | | 最終更新日 | 2023-06-14 | | 実験手法 | ELECTRON MICROSCOPY (4.66 Å) | | 主引用文献 | Diverse Murine Vaccinations Reveal Distinct Antibody Classes to Target Fusion Peptide and Variation in Peptide Length to Improve HIV Neutralization.
J.Virol., 97, 2023
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8G9V
 | | Crystal structures of 17-beta-hydroxysteroid dehydrogenase 13 | | 分子名称: | 17-beta-hydroxysteroid dehydrogenase 13, 4-{[2,5-dimethyl-3-(4-methylbenzene-1-sulfonyl)benzene-1-sulfonyl]amino}benzoic acid, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | | 著者 | Liu, S. | | 登録日 | 2023-02-22 | | 公開日 | 2023-08-09 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.645 Å) | | 主引用文献 | Structural basis of lipid-droplet localization of 17-beta-hydroxysteroid dehydrogenase 13.
Nat Commun, 14, 2023
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8G9K
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8G9J
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8G9D
 | | Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with 5- phosphonodifluoroacetamide inositol pentakisphosphate (5-PCF2Am-InsP5), an analogue of 5-InsP7 | | 分子名称: | (1,1-difluoro-2-oxo-2-{[(1s,2R,3S,4s,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl]amino}ethyl)phosphonic acid, Diphosphoinositol polyphosphate phosphohydrolase 1 | | 著者 | Zong, G, Wang, H, Shears, S. | | 登録日 | 2023-02-21 | | 公開日 | 2024-01-03 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Fluorination Influences the Bioisostery of Myo-Inositol Pyrophosphate Analogs.
Chemistry, 29, 2023
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8G9C
 | | Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with 5- difluoromethylenebisphosphonate inositol pentakisphosphate (5-PCF2P-IP5), an analogue of 5-InsP7 | | 分子名称: | CHLORIDE ION, Diphosphoinositol polyphosphate phosphohydrolase 1, FLUORIDE ION, ... | | 著者 | Zong, G, Wang, H, Shears, S. | | 登録日 | 2023-02-21 | | 公開日 | 2024-01-03 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Fluorination Influences the Bioisostery of Myo-Inositol Pyrophosphate Analogs.
Chemistry, 29, 2023
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8G9A
 | | Crystal structure of a resurrected ancestor (AncRNase) of the pancreatic-type RNases 2 and 3 sub-families | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, SULFATE ION, ... | | 著者 | Tran, T.T.Q, Pham, N.T.H, Calmettes, C, Doucet, N. | | 登録日 | 2023-02-21 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | Ancestral sequence reconstruction dissects structural and functional differences among eosinophil ribonucleases.
J.Biol.Chem., 300, 2024
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8G98
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8G97
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8G96
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8G93
 | | Crystal structures of 17-beta-hydroxysteroid dehydrogenase 13 | | 分子名称: | 3-fluoro-N-({(1r,4r)-4-[(2-fluorophenoxy)methyl]-1-hydroxycyclohexyl}methyl)-4-hydroxybenzamide, Hydroxysteroid 17-beta dehydrogenase 13, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | 著者 | Liu, S. | | 登録日 | 2023-02-21 | | 公開日 | 2023-08-09 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | Structural basis of lipid-droplet localization of 17-beta-hydroxysteroid dehydrogenase 13.
Nat Commun, 14, 2023
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8G92
 | | Structure of inhibitor 16d-bound SPNS2 | | 分子名称: | 3-[3-(4-decylphenyl)-1,2,4-oxadiazol-5-yl]propan-1-amine, Sphingosine-1-phosphate transporter SPNS2 | | 著者 | Chen, H, Li, X. | | 登録日 | 2023-02-21 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-12-13 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate.
Cell, 186, 2023
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8G91
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