8G9D

Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with 5- phosphonodifluoroacetamide inositol pentakisphosphate (5-PCF2Am-InsP5), an analogue of 5-InsP7

Summary for 8G9D

• Entry DOI: 10.2210/pdb8g9d/pdb
• Descriptor: Diphosphoinositol polyphosphate phosphohydrolase 1, (1,1-difluoro-2-oxo-2-{[(1s,2R,3S,4s,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl]amino}ethyl)phosphonic acid (3 entities in total)
• Functional Keywords: phosphatase, nudix, catalysis mechanism, substrate specificity, inositol, inositol pyrophosphate, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 20234.04

Authors

Zong, G.,Wang, H.,Shears, S. (deposition date: 2023-02-21, release date: 2024-01-03)

• Primary citation: Hostachy, S.,Wang, H.,Zong, G.,Franke, K.,Riley, A.M.,Schmieder, P.,Potter, B.V.L.,Shears, S.B.,Fiedler, D.; Fluorination Influences the Bioisostery of Myo-Inositol Pyrophosphate Analogs.; Chemistry, 29:e202302426-e202302426, 2023; PubMed: 37773020; DOI: 10.1002/chem.202302426

Experimental method

X-RAY DIFFRACTION (1.6 Å)