8GG3
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![BU of 8gg3 by Molmil](/molmil-images/mine/8gg3) | CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #9 of 20) | 分子名称: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Papasergi-Scott, M.M, Skiniotis, G. | 登録日 | 2023-03-08 | 公開日 | 2024-03-06 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8GG2
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![BU of 8gg2 by Molmil](/molmil-images/mine/8gg2) | CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #8 of 20) | 分子名称: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Papasergi-Scott, M.M, Skiniotis, G. | 登録日 | 2023-03-08 | 公開日 | 2024-03-06 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8GG1
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![BU of 8gg1 by Molmil](/molmil-images/mine/8gg1) | CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #7 of 20) | 分子名称: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Papasergi-Scott, M.M, Skiniotis, G. | 登録日 | 2023-03-08 | 公開日 | 2024-03-06 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8GG0
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![BU of 8gg0 by Molmil](/molmil-images/mine/8gg0) | CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #6 of 20) | 分子名称: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Papasergi-Scott, M.M, Skiniotis, G. | 登録日 | 2023-03-08 | 公開日 | 2024-03-06 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8GFZ
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![BU of 8gfz by Molmil](/molmil-images/mine/8gfz) | CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #5 of 20) | 分子名称: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Papasergi-Scott, M.M, Skiniotis, G. | 登録日 | 2023-03-08 | 公開日 | 2024-03-06 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8GFY
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![BU of 8gfy by Molmil](/molmil-images/mine/8gfy) | CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #4 of 20) | 分子名称: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Papasergi-Scott, M.M, Skiniotis, G. | 登録日 | 2023-03-08 | 公開日 | 2024-03-06 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8GFX
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![BU of 8gfx by Molmil](/molmil-images/mine/8gfx) | CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #3 of 20) | 分子名称: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Papasergi-Scott, M.M, Skiniotis, G. | 登録日 | 2023-03-08 | 公開日 | 2024-03-06 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8GFW
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![BU of 8gfw by Molmil](/molmil-images/mine/8gfw) | CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #2 of 20) | 分子名称: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Papasergi-Scott, M.M, Skiniotis, G. | 登録日 | 2023-03-08 | 公開日 | 2024-03-06 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8GFV
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![BU of 8gfv by Molmil](/molmil-images/mine/8gfv) | CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #1 of 20) | 分子名称: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Papasergi-Scott, M.M, Skiniotis, G. | 登録日 | 2023-03-08 | 公開日 | 2024-03-06 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8GFR
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![BU of 8gfr by Molmil](/molmil-images/mine/8gfr) | Room temperature X-ray structure of truncated SARS-CoV-2 main protease C145A mutant, residues 1-304, in complex with NBH2 | 分子名称: | (1R,2S,5S)-N-{(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl}-6,6-dimethyl-3-[3-methyl-N-({1-[(2-methylpropane-2-sulfonyl)methyl]cyclohexyl}carbamoyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | 著者 | Kovalevsky, A, Coates, L. | 登録日 | 2023-03-08 | 公開日 | 2023-07-12 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Contribution of the catalytic dyad of SARS-CoV-2 main protease to binding covalent and noncovalent inhibitors. J.Biol.Chem., 299, 2023
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8GFO
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![BU of 8gfo by Molmil](/molmil-images/mine/8gfo) | |
8GFN
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![BU of 8gfn by Molmil](/molmil-images/mine/8gfn) | Room temperature X-ray structure of truncated SARS-CoV-2 main protease C145A mutant, residues 1-304, in complex with BBH1 | 分子名称: | (1R,2S,5S)-N-{(2S)-1-(1,3-benzothiazol-2-yl)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-3-[N-(tert-butylcarbamoyl)-3-methyl-L-valyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | 著者 | Kovalevsky, A, Coates, L. | 登録日 | 2023-03-08 | 公開日 | 2023-07-12 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Contribution of the catalytic dyad of SARS-CoV-2 main protease to binding covalent and noncovalent inhibitors. J.Biol.Chem., 299, 2023
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8GFA
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![BU of 8gfa by Molmil](/molmil-images/mine/8gfa) | Cryo-EM structure of human TRPV1 in complex with the analgesic drug SB-366791 | 分子名称: | (2E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-enamide, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, ... | 著者 | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | 登録日 | 2023-03-07 | 公開日 | 2023-05-10 | 実験手法 | ELECTRON MICROSCOPY (2.29 Å) | 主引用文献 | Human TRPV1 structure and inhibition by the analgesic SB-366791. Nat Commun, 14, 2023
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8GF9
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![BU of 8gf9 by Molmil](/molmil-images/mine/8gf9) | Cryo-EM structure of human TRPV1 in cNW11 nanodisc and POPC:POPE:POPG lipids | 分子名称: | (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, ... | 著者 | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | 登録日 | 2023-03-07 | 公開日 | 2023-05-10 | 実験手法 | ELECTRON MICROSCOPY (2.58 Å) | 主引用文献 | Human TRPV1 structure and inhibition by the analgesic SB-366791. Nat Commun, 14, 2023
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8GF8
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![BU of 8gf8 by Molmil](/molmil-images/mine/8gf8) | Cryo-EM structure of human TRPV1 in cNW11 nanodisc and soybean lipids | 分子名称: | (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, ... | 著者 | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | 登録日 | 2023-03-07 | 公開日 | 2023-05-10 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Human TRPV1 structure and inhibition by the analgesic SB-366791. Nat Commun, 14, 2023
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8GF3
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![BU of 8gf3 by Molmil](/molmil-images/mine/8gf3) | Crystallographic structure from BlMan5_7 | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, ... | 著者 | Briganti, L, Araujo, E.A, Polikarpov, I. | 登録日 | 2023-03-07 | 公開日 | 2024-04-17 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Crystallographic structure from BlMan5_7 To be published
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8GEZ
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![BU of 8gez by Molmil](/molmil-images/mine/8gez) | |
8GEY
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![BU of 8gey by Molmil](/molmil-images/mine/8gey) | Crystal structure of human cellular retinol binding protein 1 in complex with 4-(hydroxymethyl)-1-[(4-methoxy-5,6,7,8-tetrahydronaphthalen-1-yl)sulfonyl]piperidin-4-ol | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-(hydroxymethyl)-1-(4-methoxy-5,6,7,8-tetrahydronaphthalene-1-sulfonyl)piperidin-4-ol, Retinol-binding protein 1 | 著者 | Plau, J, Golczak, M. | 登録日 | 2023-03-07 | 公開日 | 2023-10-04 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Discovery of Nonretinoid Inhibitors of CRBP1: Structural and Dynamic Insights for Ligand-Binding Mechanisms. Acs Chem.Biol., 18, 2023
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8GEU
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![BU of 8geu by Molmil](/molmil-images/mine/8geu) | Crystal structure of human cellular retinol binding protein 1 in complex with methyl({3-[1-(4-methylphenyl)cyclopentyl]-1,2,4-oxadiazol-5-yl}methyl)[(1-methylpyrazol-4-yl)methyl]amine | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, N-methyl-1-{3-[1-(4-methylphenyl)cyclopentyl]-1,2,4-oxadiazol-5-yl}-N-[(1-methyl-1H-pyrazol-4-yl)methyl]methanamine, Retinol-binding protein 1 | 著者 | Plau, J, Golczak, M. | 登録日 | 2023-03-07 | 公開日 | 2023-10-11 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Discovery of Nonretinoid Inhibitors of CRBP1: Structural and Dynamic Insights for Ligand-Binding Mechanisms. Acs Chem.Biol., 18, 2023
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8GET
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![BU of 8get by Molmil](/molmil-images/mine/8get) | R. hominis 2 beta-glucuronidase bound to norquetiapine-glucuronide | 分子名称: | 11-(4-beta-D-glucopyranuronosylpiperazin-1-yl)dibenzo[b,f][1,4]thiazepine, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... | 著者 | Simpson, J.B, Redinbo, M.R. | 登録日 | 2023-03-07 | 公開日 | 2024-03-20 | 最終更新日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Gut microbial beta-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics. Cell Host Microbe, 32, 2024
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8GES
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![BU of 8ges by Molmil](/molmil-images/mine/8ges) | R. hominis 2 beta-glucuronidase bound to UNC10201652-glucuronide | 分子名称: | 8-(4-beta-D-glucopyranuronosylpiperazin-1-yl)-5-(morpholin-4-yl)-1,2,3,4-tetrahydro[1,2,3]triazino[4',5':4,5]thieno[2,3 -c]isoquinoline, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... | 著者 | Simpson, J.B, Redinbo, M.R. | 登録日 | 2023-03-07 | 公開日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Diverse Human Therapeutics Impact Hormone and Neurotransmitter Homeostasis by Inhibiting Gut Microbial Enzymes To Be Published
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8GEQ
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![BU of 8geq by Molmil](/molmil-images/mine/8geq) | |
8GEO
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![BU of 8geo by Molmil](/molmil-images/mine/8geo) | E. eligens beta-glucuronidase bound to 3-OH-desloratidine-glucuronide | 分子名称: | 8-chloro-11-(1-beta-D-glucopyranuronosylpiperidin-4-ylidene)-3-hydroxy-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine, Beta-glucuronidase, GLYCEROL | 著者 | Simpson, J.B, Redinbo, M.R. | 登録日 | 2023-03-07 | 公開日 | 2024-03-20 | 最終更新日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | 主引用文献 | Gut microbial beta-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics. Cell Host Microbe, 32, 2024
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8GEL
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![BU of 8gel by Molmil](/molmil-images/mine/8gel) | Cryo-EM structure of synthetic tetrameric building block sC4 | 分子名称: | sC4 | 著者 | Redler, R.L, Huddy, T.F, Hsia, Y, Baker, D, Ekiert, D, Bhabha, G. | 登録日 | 2023-03-07 | 公開日 | 2024-03-13 | 最終更新日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Blueprinting extendable nanomaterials with standardized protein blocks. Nature, 627, 2024
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8GEJ
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![BU of 8gej by Molmil](/molmil-images/mine/8gej) | CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#20 of 20) | 分子名称: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Papasergi-Scott, M.M, Skiniotis, G. | 登録日 | 2023-03-06 | 公開日 | 2024-03-06 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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