8GFN

Room temperature X-ray structure of truncated SARS-CoV-2 main protease C145A mutant, residues 1-304, in complex with BBH1

Summary for 8GFN

Entry DOI	10.2210/pdb8gfn/pdb
Related	8GFK
Descriptor	3C-like proteinase nsp5, (1R,2S,5S)-N-{(2S)-1-(1,3-benzothiazol-2-yl)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-3-[N-(tert-butylcarbamoyl)-3-methyl-L-valyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide (3 entities in total)
Functional Keywords	viral cysteine protease, inactive c145a mutant, homodimer, inhibitor complex, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2)
Total number of polymer chains	2
Total formula weight	68314.00
Authors	Kovalevsky, A.,Coates, L. (deposition date: 2023-03-08, release date: 2023-07-12)
Primary citation	Kovalevsky, A.,Aniana, A.,Coates, L.,Bonnesen, P.V.,Nashed, N.T.,Louis, J.M. Contribution of the catalytic dyad of SARS-CoV-2 main protease to binding covalent and noncovalent inhibitors. J.Biol.Chem., 299:104886-104886, 2023 Cited by PubMed: 37271339 DOI: 10.1016/j.jbc.2023.104886 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation