PDB: 66324 件ウェブページステータス検索Chemie searchBIRD

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2FSO	mitogen activated protein kinase p38alpha (D176A) activating mutant 分子名称: Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside 著者 Diskin, R, Livnah, O. 登録日 2006-01-23 公開日 2006-12-05 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Structures of p38alpha Active Mutants Reveal Conformational Changes in L16 Loop that Induce Autophosphorylation and Activation J.Mol.Biol., 365, 2007
2FSL	mitogen activated protein kinase p38alpha (D176A+F327S) activating mutant form-A 分子名称: Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside 著者 Diskin, R, Livnah, O. 登録日 2006-01-23 公開日 2006-12-05 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structures of p38alpha Active Mutants Reveal Conformational Changes in L16 Loop that Induce Autophosphorylation and Activation J.Mol.Biol., 365, 2007
3EFX	Novel binding site identified in a hybrid between cholera toxin and heat-labile enterotoxin, 1.9A crystal structure reveals the details 分子名称: Cholera enterotoxin subunit B, Heat-labile enterotoxin B chain, alpha-L-fucopyranose-(1-2)-[2-acetamido-2-deoxy-alpha-D-galactopyranose-(1-3)]beta-D-galactopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]beta-D-glucopyranose 著者 Holmner, A, Lebens, M, Teneberg, S, Angstrom, J, Okvist, M, Krengel, U. 登録日 2008-09-10 公開日 2008-09-23 最終更新日 2024-04-10 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Novel binding site identified in a hybrid between cholera toxin and heat-labile enterotoxin: 1.9 A crystal structure reveals the details Structure, 12, 2004
3ECM	Crystal structure of the unliganded PDE8A catalytic domain 分子名称: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ZINC ION 著者 Wang, H, Yan, Z, Yang, S, Cai, J, Robinson, H, Ke, H. 登録日 2008-09-01 公開日 2008-11-25 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity Biochemistry, 47, 2008
3FAS	X-ray structure of iGluR4 flip ligand-binding core (S1S2) in complex with (S)-glutamate at 1.40A resolution 分子名称: GLUTAMIC ACID, GLYCEROL, Glutamate receptor 4, ... 著者 Kasper, C, Frydenvang, K, Naur, P, Gajhede, M, Kastrup, J.S. 登録日 2008-11-18 公開日 2008-12-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4 Febs Lett., 582, 2008
3G10	Structure of S. pombe Pop2p - Mg2+ and Mn2+ bound form 分子名称: CCR4-Not complex subunit Caf1, MAGNESIUM ION, MANGANESE (II) ION 著者 Andersen, K.R, Jonstrup, A.T, Van, L.B, Brodersen, D.E. 登録日 2009-01-29 公開日 2009-03-31 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.597 Å) 主引用文献 The activity and selectivity of fission yeast Pop2p are affected by a high affinity for Zn2+ and Mn2+ in the active site Rna, 15, 2009
3G0Z	Structure of S. pombe Pop2p - Zn2+ and Mn2+ bound form 分子名称: CCR4-Not complex subunit Caf1, MANGANESE (II) ION, ZINC ION 著者 Andersen, K.R, Jonstrup, A.T, Van, L.B, Brodersen, D.E. 登録日 2009-01-29 公開日 2009-03-31 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.004 Å) 主引用文献 The activity and selectivity of fission yeast Pop2p are affected by a high affinity for Zn2+ and Mn2+ in the active site Rna, 15, 2009
3G6W	Asymetric GTP bound structure of UPRTase from Sulfolobus solfataricus containing PRPP-mg2+ in half of the active sites and R5P and PPi in the other half 分子名称: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 5-O-phosphono-alpha-D-ribofuranose, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Kadziola, A, Christoffersen, S. 登録日 2009-02-09 公開日 2009-09-01 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural and kinetic studies of the allosteric transition in Sulfolobus solfataricus uracil phosphoribosyltransferase: Permanent activation by engineering of the C-terminus J.Mol.Biol., 393, 2009
3GJC	Crystal Structure of the E290S mutant of LeuT with bound OG 分子名称: LEUCINE, SODIUM ION, Transporter, ... 著者 Winther, A.M.L, Quick, M, Javitch, J.A, Nissen, P. 登録日 2009-03-08 公開日 2009-04-28 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation Proc.Natl.Acad.Sci.USA, 106, 2009
3ECN	Crystal structure of PDE8A catalytic domain in complex with IBMX 分子名称: 3-ISOBUTYL-1-METHYLXANTHINE, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ... 著者 Wang, H, Yan, Z, Yang, S, Cai, J, Robinson, H, Ke, H. 登録日 2008-09-01 公開日 2008-11-25 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity Biochemistry, 47, 2008
3H6X	Crystal structure of dUTPase from Streptococcus mutans 分子名称: dUTPase 著者 Li, G.L, Wang, K.T, Liu, X, Li, L.F, Su, X.D. 登録日 2009-04-24 公開日 2010-05-05 最終更新日 2018-05-23 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure and activity analysis of dUTP nucleotidohydrolase from Streptococcus mutans To be Published
3FAT	X-ray structure of iGluR4 flip ligand-binding core (S1S2) in complex with (S)-AMPA at 1.90A resolution 分子名称: (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID, ACETIC ACID, GLYCEROL, ... 著者 Kasper, C, Frydenvang, K, Naur, P, Gajhede, M, Kastrup, J.S. 登録日 2008-11-18 公開日 2008-12-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4 Febs Lett., 582, 2008
3DHZ	Apo (iron free) structure of C. ammoniagenes R2 protein 分子名称: FE (II) ION, Ribonucleotide reductase subunit R2F 著者 Hogbom, M, Nordlund, P. 登録日 2008-06-19 公開日 2008-07-01 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Structural and mutational studies of the carboxylate cluster in Iron-free Ribonucleotide Reductase R2. Biochemistry, 43, 2004
3DTG	Structural analysis of mycobacterial branched chain aminotransferase- implications for inhibitor design 分子名称: Branched-chain amino acid aminotransferase, GLYCEROL, O-benzylhydroxylamine, ... 著者 Castell, A, Unge, T. 登録日 2008-07-15 公開日 2009-06-23 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural analysis of mycobacterial branched chain aminotransferase - implications for inhibitor design To be Published
3HHC	Interferon-lambda is functionally an interferon but structurally related to the IL-10 family 分子名称: IODIDE ION, Interleukin-28B 著者 Gad, H.H, Hamming, O.J, Hartmann, R. 登録日 2009-05-15 公開日 2009-07-21 最終更新日 2018-01-24 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Interferon-{lambda} Is Functionally an Interferon but Structurally Related to the Interleukin-10 Family J.Biol.Chem., 284, 2009
3HFO	Crystal Structure of an Hfq protein from Synechocystis sp. 分子名称: Ssr3341 protein 著者 Boggild, A, Overgaard, M, Valentin-Hansen, P, Brodersen, D.E. 登録日 2009-05-12 公開日 2009-07-14 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Cyanobacteria contain a structural homologue of the Hfq protein with altered RNA-binding properties. Febs J., 276, 2009
3EEO	M. HhaI co-crystallized with synthetic dsDNA containing a propane diol in place of the deoxycytidine residue targeted for methylation. 分子名称: 5'-D(P*DCP*DCP*DAP*DTP*DGP*DCP*DGP*DCP*DTP*DGP*DAP*DC)-3', 5'-D(P*DGP*DTP*DCP*DAP*DGP*(PDI)P*DGP*DCP*DAP*DTP*DGP*DG)-3', Modification methylase HhaI, ... 著者 Porta, J.C, Christman, J.K, Borgstahl, G.E.O. 登録日 2008-09-05 公開日 2010-03-02 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 M. HhaI co-crystallized with synthetic dsDNA containing a propane diol in place of the deoxycytidine residue targeted for methylation. To be Published
2Q2Z	Crystal Structure of KSP in Complex with Inhibitor 22 分子名称: 1-[(4R)-4-[3-(4-ACETYLPIPERAZIN-1-YL)PROPYL]-1-(2-FLUORO-5-METHYLPHENYL)-4-PHENYL-4,5-DIHYDRO-1H-PYRAZOL-3-YL]ETHANONE, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, ... 著者 Yan, Y. 登録日 2007-05-29 公開日 2007-09-18 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP. Bioorg.Med.Chem.Lett., 17, 2007
2GM2	NMR structure of Xanthomonas campestris XCC1710: Northeast Structural Genomics Consortium target XcR35 分子名称: conserved hypothetical protein 著者 Cort, J.R, Xiao, R, Wang, D.Y, Ma, L.C, Ciano, M, Montelione, G.T, Ramelot, T.A, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) 登録日 2006-04-05 公開日 2006-04-25 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 NMR structure of Xanthomonas campestris XCC1710 protein To be Published
4YT4	Iron guanylylpyridinol (FeGP) cofactor-reconstituted HmdII from Methanocaldococcus jannaschii 分子名称: H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338, iron-guanylyl pyridinol cofactor 著者 Fujishiro, T, Ermler, U, Shima, S. 登録日 2015-03-17 公開日 2015-07-01 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Towards a functional identification of catalytically inactive [Fe]-hydrogenase paralogs. Febs J., 282, 2015
3ICR	Crystal structure of oxidized Bacillus anthracis CoADR-RHD 分子名称: COENZYME A, Coenzyme A-Disulfide Reductase, FLAVIN-ADENINE DINUCLEOTIDE 著者 Wallen, J.R, Claiborne, A. 登録日 2009-07-18 公開日 2009-11-17 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure and catalytic properties of Bacillus anthracis CoADR-RHD: implications for flavin-linked sulfur trafficking. Biochemistry, 48, 2009
3WR1	Crystal structure of Cormorant (Phalacrocorax carbo) hemoglobin 分子名称: Hemoglobin subunit alpha-A, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE 著者 Jagadeesan, G, Vinodh Kumar, V, Peters, H.G, Malathy, P, Harikrishna Etti, S, Gunasekaran, K, Aravindhan, S. 登録日 2014-02-09 公開日 2014-03-05 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Crystal structure of Cormorant (Phalacrocorax carbo) hemoglobin To be Published
4AA4	P38ALPHA MAP KINASE BOUND TO CMPD 22 分子名称: MITOGEN-ACTIVATED PROTEIN KINASE 14, N-[4-METHYL-3-[6-(4-METHYLPIPERAZIN-1-YL)-4-OXIDANYLIDENE-QUINAZOLIN-3-YL]PHENYL]FURAN-3-CARBOXAMIDE 著者 Gerhardt, S, Hargreaves, D. 登録日 2011-11-30 公開日 2012-05-16 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The Discovery of N-Cyclopropyl-4-Methyl-3-[6--(4-Methylpiperazin-1-Yl-4-Oxoquinazolin-3(4H)-Yl]Benzamide (Azd6703), a Clinical P38Alpha Map Kinase Inhibitor for the Treatment of Inflammatory Diseases Bioorg.Med.Chem.Lett., 22, 2012
4A9Y	P38ALPHA MAP KINASE BOUND TO CMPD 8 分子名称: MITOGEN-ACTIVATED PROTEIN KINASE 14, N-(3-{[7-METHOXY-6-(2-PYRROLIDIN-1-YLETHOXY)QUINAZOLIN-4-YL]AMINO}-4-METHYLPHENYL)-2-MORPHOLIN-4-YLISONICOTINAMIDE 著者 Gerhardt, S, Hargreaves, D. 登録日 2011-11-29 公開日 2012-05-16 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The Discovery of N-Cyclopropyl-4-Methyl-3-[6--(4-Methylpiperazin-1-Yl-4-Oxoquinazolin-3(4H)-Yl]Benzamide (Azd6703), a Clinical P38Alpha Map Kinase Inhibitor for the Treatment of Inflammatory Diseases Bioorg.Med.Chem.Lett., 22, 2012
4AA0	P38ALPHA MAP KINASE BOUND TO CMPD 2 分子名称: MITOGEN-ACTIVATED PROTEIN KINASE 14, N-[4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxidanylidene-quinazolin-3-yl]phenyl]-2-morpholin-4-yl-pyridine-4-carboxamide 著者 Gerhardt, S, Hargreaves, D. 登録日 2011-11-30 公開日 2012-05-16 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 The Discovery of N-Cyclopropyl-4-Methyl-3-[6--(4-Methylpiperazin-1-Yl-4-Oxoquinazolin-3(4H)-Yl]Benzamide (Azd6703), a Clinical P38Alpha Map Kinase Inhibitor for the Treatment of Inflammatory Diseases Bioorg.Med.Chem.Lett., 22, 2012

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