3HHC

Interferon-lambda is functionally an interferon but structurally related to the IL-10 family

Summary for 3HHC

• Entry DOI: 10.2210/pdb3hhc/pdb
• Descriptor: Interleukin-28B, IODIDE ION (3 entities in total)
• Functional Keywords: interferon, il-22, antiviral, antiviral defense, cytokine, secreted
• Biological source: Homo sapiens (human)
• Cellular location: Secreted : Q8IZI9
• Total number of polymer chains: 4
• Total formula weight: 91395.27

Authors

Gad, H.H.,Hamming, O.J.,Hartmann, R. (deposition date: 2009-05-15, release date: 2009-07-21, Last modification date: 2024-10-16)

Primary citation

Gad, H.H.,Dellgren, C.,Hamming, O.J.,Vends, S.,Paludan, S.R.,Hartmann, R.
Interferon-{lambda} Is Functionally an Interferon but Structurally Related to the Interleukin-10 Family
J.Biol.Chem., 284:20869-20875, 2009

PubMed Abstract: Interferon-lambda (IFN-lambda) is an antiviral cytokine that signals through a distinct receptor complex, composed of the IFN-lambdaR1 and interleukin-10R2 (IL-10R2) receptor chains. We have determined the crystal structure of human IFN-lambda3 and characterized the interaction with its receptor complex through structure-based site-directed mutagenesis. The ability of IFN-lambda3 mutants to signal was determined by measuring the antiviral activity and induced STAT2 phosphorylation. In conclusion, our data show that, although IFN-lambda is functionally an interferon, it is clearly structurally related to members of the IL-10 family. In particular, we found an interesting similarity between IFN-lambda and IL-22, and we suggest that IFN-lambda and IL-22 possess parallel functions, protecting epithelial tissue against viral and bacterial infections, respectively.

PubMed: 19457860
DOI: 10.1074/jbc.M109.002923

Experimental method

X-RAY DIFFRACTION (2.8 Å)