PDB: 45459 件ウェブページステータス検索Chemie searchBIRD

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7VPR	Crystal structure of the ligand-binding domain of C. glabrata Upc2 in complex with ergosterol 分子名称: ERGOSTEROL, Sterol uptake control protein 2 (Upc2) 著者 Tan, L, Im, Y.J. 登録日 2021-10-17 公開日 2022-09-07 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.59 Å) 主引用文献 Structural basis for activation of fungal sterol receptor Upc2 and azole resistance. Nat.Chem.Biol., 18, 2022
5U6O	Structure of the human HCN1 hyperpolarization-activated cyclic nucleotide-gated ion channel 分子名称: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 著者 Lee, C.-H, MacKinnon, R. 登録日 2016-12-08 公開日 2017-01-25 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structures of the Human HCN1 Hyperpolarization-Activated Channel. Cell, 168, 2017
7V4Q	The crystal structure of the apo form of KFDV NS3H 分子名称: Serine protease NS3 著者 Zhang, C.Y, Jin, T.C. 登録日 2021-08-14 公開日 2022-08-31 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Kyasanur Forest disease virus NS3 helicase: Insights into structure, activity, and inhibitors. Int.J.Biol.Macromol., 2023
7K9H	SARS-CoV-2 Spike in complex with neutralizing Fab 2B04 (one up, two down conformation) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2B04 heavy chain, ... 著者 Errico, J.M, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2020-09-29 公開日 2021-09-29 最終更新日 2021-11-10 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural mechanism of SARS-CoV-2 neutralization by two murine antibodies targeting the RBD. Cell Rep, 37, 2021
7KC5	X-ray structure of Lfa-1 I domain in complex with BMS-68852 collected at 273 K 分子名称: 6-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl]pyridine-3-carboxylic acid, Integrin alpha-L, MAGNESIUM ION 著者 Woldeyes, R.A, Hallenbeck, K.K, Pfaff, S.J, Lee, G, Cortez, S.V, Kelly, M.J, Akassoglou, K, Arkin, M.R, Fraser, J.S. 登録日 2020-10-05 公開日 2021-10-06 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Divergent conformational dynamics controls allosteric ligand accessibility across evolutionarily related I-domain-containing integrins To Be Published
7K9J	SARS-CoV-2 Spike in complex with neutralizing Fab 2H04 (three down conformation) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2H04 heavy chain, ... 著者 Errico, J.M, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2020-09-29 公開日 2021-09-29 最終更新日 2021-11-10 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural mechanism of SARS-CoV-2 neutralization by two murine antibodies targeting the RBD. Cell Rep, 37, 2021
7KC3	X-ray structure of Lfa-1 I domain collected at 273 K 分子名称: Integrin alpha-L, MAGNESIUM ION 著者 Woldeyes, R.A, Hallenbeck, K.K, Pfaff, S.J, Lee, G, Cortez, S.V, Kelly, M.J, Akassoglou, K, Arkin, M.R, Fraser, J.S. 登録日 2020-10-05 公開日 2021-10-06 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Divergent conformational dynamics controls allosteric ligand accessibility across evolutionarily related I-domain-containing integrins To Be Published
7KC6	X-ray structure of Lfa-1 I domain in complex with Lovastatin collected at 273 K 分子名称: Integrin alpha-L, LOVASTATIN, MAGNESIUM ION 著者 Woldeyes, R.A, Hallenbeck, K.K, Pfaff, S.J, Lee, G, Cortez, S.V, Kelly, M.J, Akassoglou, K, Arkin, M.R, Fraser, J.S. 登録日 2020-10-05 公開日 2021-10-06 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Divergent conformational dynamics controls allosteric ligand accessibility across evolutionarily related I-domain-containing integrins To Be Published
7VKA	Crystal Structure of GH3.6 in complex with an inhibitor 分子名称: ADENOSINE MONOPHOSPHATE, GLYCEROL, Indole-3-acetic acid-amido synthetase GH3.6, ... 著者 Wang, N, Luo, M, Bao, H, Huang, H. 登録日 2021-09-29 公開日 2022-08-31 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.401 Å) 主引用文献 Chemical genetic screening identifies nalacin as an inhibitor of GH3 amido synthetase for auxin conjugation. Proc.Natl.Acad.Sci.USA, 119, 2022
5TSR	Crystal structure of PRL-3 phosphatase in complex with the Bateman domain of CNNM3 magnesium transporter 分子名称: Metal transporter CNNM3, Protein tyrosine phosphatase type IVA 3 著者 Kozlov, G, Zhang, H, Gehring, K. 登録日 2016-10-31 公開日 2017-02-08 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.188 Å) 主引用文献 PRL3 phosphatase active site is required for binding the putative magnesium transporter CNNM3. Sci Rep, 7, 2017
5TT2	Inactive conformation of engineered human cystathionine gamma lyase (E59N, R119L, E339V) to depleting methionine 分子名称: Cystathionine gamma-lyase, SULFATE ION 著者 Yan, W, Zhang, Y. 登録日 2016-10-31 公開日 2017-10-11 最終更新日 2019-11-27 実験手法 X-RAY DIFFRACTION (2.949 Å) 主引用文献 Structural Snapshots of an Engineered Cystathionine-gamma-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site. Biochemistry, 56, 2017
5U1T	Crystal structure of the Saccharomyces cerevisiae separase-securin complex at 2.6 angstrom resolution 分子名称: Securin, Separin 著者 Luo, S, Tong, L. 登録日 2016-11-29 公開日 2017-02-08 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Molecular mechanism for the regulation of yeast separase by securin. Nature, 542, 2017
7VGN	Crystal structure of CmnC 分子名称: 2-OXOGLUTARIC ACID, ACETATE ION, CmnC, ... 著者 Huang, S.J, Hsiao, Y.H, Lin, E.C, Lee, Y.C, Zheng, Y.Z, Chang, C.Y. 登録日 2021-09-17 公開日 2022-09-21 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Crystal structure of the alpha-ketoglutarate-dependent non-heme iron oxygenase CmnC in capreomycin biosynthesis and its engineering to catalyze hydroxylation of the substrate enantiomer. Front Chem, 10, 2022
7VKF	Reduced enzyme of FAD-dpendent Glucose Dehydrogenase complex with D-glucono-1,5-lactone at pH8.5 分子名称: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, D-glucono-1,5-lactone, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, ... 著者 Nakajima, Y, Nishiya, Y, Ito, K. 登録日 2021-09-29 公開日 2022-10-05 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Conformational change of catalytic residue in reduced enzyme of FAD-dependent Glucose Dehydrogenase at pH6.5 To Be Published
7VGL	Crystal structure of CmnC 分子名称: ACETATE ION, CmnC 著者 Hsiao, Y.H, Huang, S.J, Lin, E.C, Lee, Y.C, Zheng, Y.Z, Chang, C.Y. 登録日 2021-09-17 公開日 2022-09-21 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Crystal structure of the alpha-ketoglutarate-dependent non-heme iron oxygenase CmnC in capreomycin biosynthesis and its engineering to catalyze hydroxylation of the substrate enantiomer. Front Chem, 10, 2022
5U9K	Crystal structure of V71F mutant of the FKBP domain of human aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) 分子名称: Aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) 著者 Yadav, R.P, Gakhar, L, Liping, Y, Artemyev, N.O. 登録日 2016-12-16 公開日 2017-07-26 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Unique structural features of the AIPL1-FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5TOA	Crystal Structure of ER beta bound to Estradiol 分子名称: ESTRADIOL, Estrogen receptor beta 著者 Textor, L, Nascimento, A.S, Polikarpov, I. 登録日 2016-10-17 公開日 2017-06-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 An alternative conformation of ER beta bound to estradiol reveals H12 in a stable antagonist position. Sci Rep, 7, 2017
5TPA	Structure of the human GluN1/GluN2A LBD in complex with compound 9 (GNE3500) 分子名称: (1R,2R)-2-(2-{[5-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-7-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-6-yl)cyclopropane-1-carbonitrile, GLUTAMIC ACID, GLYCINE, ... 著者 Wallweber, H.J.A, Lupardus, P.J. 登録日 2016-10-20 公開日 2016-11-30 最終更新日 2017-02-01 実験手法 X-RAY DIFFRACTION (2.48 Å) 主引用文献 GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile. ACS Med Chem Lett, 8, 2017
7KQP	Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with ADP-ribose (P43 crystal form) 分子名称: Non-structural protein 3, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE 著者 Correy, G.J, Young, I.D, Thompson, M.C, Fraser, J.S. 登録日 2020-11-17 公開日 2020-12-09 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (0.88 Å) 主引用文献 Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking. Sci Adv, 7, 2021
7VKD	Reduced enzyme of FAD-dpendent Glucose Dehydrogenase at pH6.5 分子名称: DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, GMC oxidoreductase 著者 Nakajima, Y, Nishiya, Y, Ito, K. 登録日 2021-09-29 公開日 2022-10-05 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Conformational change of catalytic residue in reduced enzyme of FAD-dependent Glucose Dehydrogenase at pH6.5 To Be Published
7L32	Molybdopterin biosynthesis MoaE protein from Burkholderia ambifaria MC40-6 分子名称: BROMIDE ION, MPT synthase subunit 2 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2020-12-17 公開日 2020-12-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Molybdopterin biosynthesis MoaE protein from Burkholderia ambifaria MC40-6 to be published
5U1S	Crystal structure of the Saccharomyces cerevisiae separase-securin complex at 3.0 angstrom resolution 分子名称: Securin, Separin 著者 Luo, S, Tong, L. 登録日 2016-11-29 公開日 2017-02-08 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (3.002 Å) 主引用文献 Molecular mechanism for the regulation of yeast separase by securin. Nature, 542, 2017
7WBK	Crystal structure of Legionella pneumophila effector protein Lpg0081 分子名称: Lpg0081, SULFATE ION 著者 Lee, J, Kim, H, Oh, B.H. 登録日 2021-12-16 公開日 2022-06-15 実験手法 X-RAY DIFFRACTION (2.74 Å) 主引用文献 Reversible modification of mitochondrial ADP/ATP translocases by paired Legionella effector proteins. Proc.Natl.Acad.Sci.USA, 119, 2022
7WBM	Crystal structure of Legionella pneumophila effector protein Lpg0081 分子名称: Lpg0081, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE 著者 Lee, J, Kim, H, Oh, B.H. 登録日 2021-12-17 公開日 2022-06-15 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Reversible modification of mitochondrial ADP/ATP translocases by paired Legionella effector proteins. Proc.Natl.Acad.Sci.USA, 119, 2022
7W79	Heme exporter HrtBA in complex with Mn-AMPPNP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, Putative ABC transport system integral membrane protein, ... 著者 Hisano, T, Nakamura, H, Rahman, M.M, Tosha, T, Shirouzu, M, Shiro, Y. 登録日 2021-12-04 公開日 2022-06-22 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structural basis for heme detoxification by an ATP-binding cassette-type efflux pump in gram-positive pathogenic bacteria. Proc.Natl.Acad.Sci.USA, 119, 2022

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