4NV0
 
 | | Crystal structure of cytosolic 5'-nucleotidase IIIB (cN-IIIB) bound to 7-methylguanosine | | 分子名称: | 7-METHYLGUANOSINE, 7-methylguanosine phosphate-specific 5'-nucleotidase, MAGNESIUM ION, ... | | 著者 | Monecke, T, Neumann, P, Ficner, R. | | 登録日 | 2013-12-04 | | 公開日 | 2014-03-19 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Crystal Structures of the Novel Cytosolic 5'-Nucleotidase IIIB Explain Its Preference for m7GMP
Plos One, 9, 2014
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8TO2
 | | Bottom cylinder of high-resolution phycobilisome quenched by OCP (local refinement) | | 分子名称: | Allophycocyanin alpha chain, Allophycocyanin beta chain, Allophycocyanin subunit alpha-B, ... | | 著者 | Sauer, P.V, Sutter, M, Cupellini, L. | | 登録日 | 2023-08-02 | | 公開日 | 2024-04-17 | | 実験手法 | ELECTRON MICROSCOPY (2 Å) | | 主引用文献 | Structural and quantum chemical basis for OCP-mediated quenching of phycobilisomes.
Sci Adv, 10, 2024
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8TWF
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8TWG
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9FBV
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8WD4
 | | EGFR(L858R/T790/C797S) in complex with compound 5j | | 分子名称: | CHLORIDE ION, Epidermal growth factor receptor, ~{N}-[3,3-bis(fluoranyl)propyl]-4-[[(2~{S})-butan-2-yl]amino]-6-[[2-(1-cyclopropylsulfonylpyrazol-4-yl)pyrimidin-4-yl]amino]pyridine-3-carboxamide | | 著者 | Nishikawa, Y. | | 登録日 | 2023-09-14 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-01-03 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Synthesis, activity, and their relationships of 2,4-diaminonicotinamide derivatives as EGFR inhibitors targeting C797S mutation.
Bioorg.Med.Chem.Lett., 98, 2023
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8UK6
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8TTM
 | | IgG1 Fc Heterodimer combYSelect1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin gamma-1 heavy chain | | 著者 | Azzam, T, Du, J.J, Sundberg, E.J. | | 登録日 | 2023-08-14 | | 公開日 | 2024-06-26 | | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | | 主引用文献 | Combinatorially restricted computational design of protein-protein interfaces to produce IgG heterodimers.
Sci Adv, 10, 2024
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8TUD
 | | IgG1 Fc Heterodimer combYSelect2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin gamma-1 heavy chain | | 著者 | Azzam, T, Du, J.J, Sundberg, E.J. | | 登録日 | 2023-08-16 | | 公開日 | 2024-06-26 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Combinatorially restricted computational design of protein-protein interfaces to produce IgG heterodimers.
Sci Adv, 10, 2024
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8VFU
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8TO5
 | | Central rod disk in C1 symmetry of high-resolution phycobilisome quenched by OCP (local refinement) | | 分子名称: | C-phycocyanin alpha subunit, C-phycocyanin beta subunit, PHYCOCYANOBILIN, ... | | 著者 | Sauer, P.V, Sutter, M, Cupellini, L. | | 登録日 | 2023-08-02 | | 公開日 | 2024-04-17 | | 実験手法 | ELECTRON MICROSCOPY (1.87 Å) | | 主引用文献 | Structural and quantum chemical basis for OCP-mediated quenching of phycobilisomes.
Sci Adv, 10, 2024
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8Y6H
 | | P-glycoprotein in complex with UIC2 Fab and triple elacridar molecules in LMNG detergent | | 分子名称: | ATP-dependent translocase ABCB1,mNeonGreen, UIC2 Fab heavy chain, UIC2 Fab light chain, ... | | 著者 | Hamaguchi-Suzuki, N, Adachi, N, Moriya, T, Kawasaki, M, Suzuki, K, Anzai, N, Senda, T, Murata, T. | | 登録日 | 2024-02-02 | | 公開日 | 2024-04-17 | | 実験手法 | ELECTRON MICROSCOPY (2.49 Å) | | 主引用文献 | Cryo-EM structure of P-glycoprotein bound to triple elacridar inhibitor molecules.
Biochem.Biophys.Res.Commun., 709, 2024
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8W6X
 | | Neutron structure of [NiFe]-hydrogenase from D. vulgaris Miyazaki F in its oxidized state | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, FE3-S4 CLUSTER, ... | | 著者 | Hiromoto, T, Tamada, T. | | 登録日 | 2023-08-30 | | 公開日 | 2023-09-13 | | 最終更新日 | 2023-11-15 | | 実験手法 | NEUTRON DIFFRACTION (1.04 Å), X-RAY DIFFRACTION | | 主引用文献 | New insights into the oxidation process from neutron and X-ray crystal structures of an O 2 -sensitive [NiFe]-hydrogenase.
Chem Sci, 14, 2023
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8Y6I
 | | P-glycoprotein in complex with UIC2 Fab and triple elacridar molecules in nanodisc | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, ATP-dependent translocase ABCB1,mNeonGreen, CHOLESTEROL, ... | | 著者 | Hamaguchi-Suzuki, N, Adachi, N, Moriya, T, Kawasaki, M, Suzuki, K, Anzai, N, Senda, T, Murata, T. | | 登録日 | 2024-02-02 | | 公開日 | 2024-04-17 | | 実験手法 | ELECTRON MICROSCOPY (2.54 Å) | | 主引用文献 | Cryo-EM structure of P-glycoprotein bound to triple elacridar inhibitor molecules.
Biochem.Biophys.Res.Commun., 709, 2024
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3E9U
 | | Crystal structure of Calx CBD2 domain | | 分子名称: | Na/Ca exchange protein | | 著者 | Wu, M, Zheng, L. | | 登録日 | 2008-08-23 | | 公開日 | 2009-01-27 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal structure of CBD2 from the Drosophila Na(+)/Ca(2+) exchanger: diversity of Ca(2+) regulation and its alternative splicing modification.
J.Mol.Biol., 387, 2009
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8TRO
 | | Rod from high-resolution phycobilisome quenched by OCP (local refinement) | | 分子名称: | C-phycocyanin alpha subunit, C-phycocyanin beta subunit, PHYCOCYANOBILIN, ... | | 著者 | Sauer, P.V, Sutter, M, Cupellini, L. | | 登録日 | 2023-08-09 | | 公開日 | 2024-04-17 | | 実験手法 | ELECTRON MICROSCOPY (1.9 Å) | | 主引用文献 | Structural and quantum chemical basis for OCP-mediated quenching of phycobilisomes.
Sci Adv, 10, 2024
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4HKR
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4HKS
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8IXS
 | | Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1/Nrf2 PPI Inhibitor for Treatment of Chronic Kidney Disease | | 分子名称: | (2R,3S)-3-[[(2S)-2-fluoranyl-2-(5,6,7,8-tetrahydronaphthalen-2-yl)ethanoyl]amino]-2-methyl-3-(4-methylphenyl)propanoic acid, Kelch-like ECH-associated protein 1, SULFATE ION | | 著者 | Nomura, A, Yamaguchi, K, Adachi, T. | | 登録日 | 2023-04-03 | | 公開日 | 2023-06-14 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | | 主引用文献 | Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1-Nrf2 PPI Inhibitor.
Acs Med.Chem.Lett., 14, 2023
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8IVR
 | | Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1/Nrf2 PPI Inhibitor for Treatment of Chronic Kidney Disease | | 分子名称: | (2R,3S)-2-methyl-3-(4-methylphenyl)-3-[2-(5,6,7,8-tetrahydronaphthalen-2-yl)ethanoylamino]propanoic acid, Kelch-like ECH-associated protein 1, SULFATE ION | | 著者 | Nomura, A, Yamaguchi, K, Adachi, T. | | 登録日 | 2023-03-28 | | 公開日 | 2023-06-14 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1-Nrf2 PPI Inhibitor.
Acs Med.Chem.Lett., 14, 2023
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8IVW
 | | Crystal structure of NRP2 in complex with aNRP2-10 Fab fragment | | 分子名称: | Heavy chian of antibody 10V8 Fab fragment, Light chain of antibody 10V8 Fab fragment, Neuropilin-2 | | 著者 | Geng, Y, Zhai, L. | | 登録日 | 2023-03-29 | | 公開日 | 2023-07-12 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (3.205 Å) | | 主引用文献 | Inhibition of VEGF binding to neuropilin-2 enhances chemosensitivity and inhibits metastasis in triple-negative breast cancer.
Sci Transl Med, 15, 2023
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8IVX
 | | Crystal structure of NRP2 in complex with aNRP2-14 Fab fragment | | 分子名称: | 1,2-ETHANEDIOL, Heavy chain of antibody 14V4 Fab fragment, Light chain of antibody 14V4 Fab fragment, ... | | 著者 | Geng, Y, Zhai, L. | | 登録日 | 2023-03-29 | | 公開日 | 2023-07-12 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Inhibition of VEGF binding to neuropilin-2 enhances chemosensitivity and inhibits metastasis in triple-negative breast cancer.
Sci Transl Med, 15, 2023
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8JHU
 | | Legionella effector protein SidI | | 分子名称: | Legionella pneumophila effector protein SidI | | 著者 | Wang, L, Subramanian, A, Mukherjee, S, Walter, P. | | 登録日 | 2023-05-25 | | 公開日 | 2023-08-30 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | A Legionella toxin exhibits tRNA mimicry and glycosyl transferase activity to target the translation machinery and trigger a ribotoxic stress response.
Nat.Cell Biol., 25, 2023
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6J6U
 | | Rat PTPRZ D1-D2 domain | | 分子名称: | Receptor-type tyrosine-protein phosphatase zeta | | 著者 | Sugawara, H. | | 登録日 | 2019-01-15 | | 公開日 | 2019-08-28 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.32 Å) | | 主引用文献 | A head-to-toe dimerization has physiological relevance for ligand-induced inactivation of protein tyrosine receptor type Z.
J.Biol.Chem., 294, 2019
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7L4U
 | | Crystal structure of human monoacylglycerol lipase in complex with compound 1h | | 分子名称: | (5S)-5-(3-{4-[(2-chloro-4-fluorophenoxy)methyl]piperidin-1-yl}-3-oxopropyl)pyrrolidin-2-one, CHLORIDE ION, Monoglyceride lipase | | 著者 | Qin, L, Lane, W, Skene, R.J, Dougan, D. | | 登録日 | 2020-12-21 | | 公開日 | 2021-08-11 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3-Oxo-3,4-dihydro-2 H -benzo[ b ][1,4]oxazin-6-yl Moiety.
J.Med.Chem., 64, 2021
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