PDB: 491 件ウェブページステータス検索Chemie searchBIRD

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4DLX	H-Ras Set 1 CaCl2/DTE, ordered off 分子名称: (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, CALCIUM ION, GTPase HRas, ... 著者 Holzapfel, G, Mattos, C. 登録日 2012-02-06 公開日 2012-08-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.731 Å) 主引用文献 Shift in the Equilibrium between On and Off States of the Allosteric Switch in Ras-GppNHp Affected by Small Molecules and Bulk Solvent Composition. Biochemistry, 51, 2012
6X2W	Crystal Structure of PKINES peptide bound to CRM1(E571K) 分子名称: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... 著者 Baumhardt, J.M. 登録日 2020-05-21 公開日 2020-07-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.001 Å) 主引用文献 Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
4DLS	H-Ras Set 1 CaCl2 'Mixed' 分子名称: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... 著者 Holzapfel, G, Mattos, C. 登録日 2012-02-06 公開日 2012-08-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.819 Å) 主引用文献 Shift in the Equilibrium between On and Off States of the Allosteric Switch in Ras-GppNHp Affected by Small Molecules and Bulk Solvent Composition. Biochemistry, 51, 2012
6X2P	Crystal Structure of the Mek1NES peptide bound to CRM1 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Exportin-1, GLYCEROL, ... 著者 Baumhardt, J.M. 登録日 2020-05-20 公開日 2020-07-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.401 Å) 主引用文献 Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
6X2V	Crystal Structure of PKI(DE)NES peptide bound to CRM1 分子名称: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... 著者 Baumhardt, J.M. 登録日 2020-05-21 公開日 2020-07-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.822 Å) 主引用文献 Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
4DLZ	H-Ras Set 2 Ca(OAc)2/DTE, ordered off 分子名称: (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, CALCIUM ION, GTPase HRas, ... 著者 Holzapfel, G, Mattos, C. 登録日 2012-02-06 公開日 2012-08-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.662 Å) 主引用文献 Shift in the Equilibrium between On and Off States of the Allosteric Switch in Ras-GppNHp Affected by Small Molecules and Bulk Solvent Composition. Biochemistry, 51, 2012
8HQ6	KL2 in complex with CRM1-Ran-RanBP1 分子名称: CHLORIDE ION, CRM1 isoform 1, DIMETHYL SULFOXIDE, ... 著者 Sun, Q, Jian, L. 登録日 2022-12-13 公開日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors. J.Med.Chem., 66, 2023
8HQ3	KL1 in complex with CRM1-Ran-RanBP1 分子名称: CHLORIDE ION, CRM1 isoform 1, DIMETHYL SULFOXIDE, ... 著者 Sun, Q, Jian, L. 登録日 2022-12-13 公開日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors. J.Med.Chem., 66, 2023
6X2S	Crystal Structure of Mek1(NQ)NES peptide bound to CRM 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Exportin-1, GLYCEROL, ... 著者 Baumhardt, J.M. 登録日 2020-05-20 公開日 2020-07-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.496 Å) 主引用文献 Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
6X2M	Crystal Structure of unliganded CRM1-Ran-RanBP1 分子名称: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... 著者 Baumhardt, J.M. 登録日 2020-05-20 公開日 2020-07-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.351 Å) 主引用文献 Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
6X2O	Crystal Structure of unliganded CRM1(E571K)-Ran-RanBP1 分子名称: Exportin-1, GTP-binding nuclear protein Ran, MAGNESIUM ION, ... 著者 Baumhardt, J.M. 登録日 2020-05-20 公開日 2020-07-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.551 Å) 主引用文献 Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
6X2U	Crystal Structure of PKINES peptide bound to CRM1 分子名称: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... 著者 Baumhardt, J.M. 登録日 2020-05-21 公開日 2020-07-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
6X2X	Crystal Structure of Mek1NES peptide bound to CRM1(E571K) 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Exportin-1, GLYCEROL, ... 著者 Baumhardt, J.M. 登録日 2020-05-21 公開日 2020-07-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.458 Å) 主引用文献 Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
8HQ4	B27 in complex with CRM1-Ran-RanBP1 分子名称: 3-[(4-fluorophenyl)carbonylamino]-4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]benzoic acid, CHLORIDE ION, CRM1 isoform 1, ... 著者 Lei, Y, Sun, Q. 登録日 2022-12-13 公開日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 B27 in complex with CRM1-Ran-RanBP1 To Be Published
6X2Y	Crystal Structure of mDia2NES peptide bound to CRM1(E571K) 分子名称: 1,2-ETHANEDIOL, Exportin-1, GLYCEROL, ... 著者 Baumhardt, J.M. 登録日 2020-05-21 公開日 2020-07-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.304 Å) 主引用文献 Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
6X2R	Crystal Structure of the 4E-TNES peptide bound to CRM1 分子名称: Eukaryotic translation initiation factor 4E transporter, Exportin-1, GLYCEROL, ... 著者 Baumhardt, J.M. 登録日 2020-05-20 公開日 2020-07-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.299 Å) 主引用文献 Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
8HQ5	G6 in complex with CRM1-Ran-RanBP1 分子名称: 3-[(4-bromophenyl)carbonylamino]-4-[4-(5-chloranyl-2-methyl-phenyl)piperazin-1-yl]benzoic acid, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, ... 著者 Sun, Q, Lei, Y. 登録日 2022-12-13 公開日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 F1 in complex with CRM1-Ran-RanBP1 To Be Published
8HUG	F1 in complex with CRM1-Ran-RanBP1 分子名称: 4-[4-(3-chlorophenyl)piperazin-1-yl]-3-[(3-fluorophenyl)sulfonylamino]benzoic acid, CHLORIDE ION, CRM1 isoform 1, ... 著者 Sun, Q, Lei, Y. 登録日 2022-12-23 公開日 2023-12-27 最終更新日 2024-07-10 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Discovery of a Hidden Pocket beneath the NES Groove by Novel Noncovalent CRM1 Inhibitors. J.Med.Chem., 66, 2023
8HUF	B28 in complex with CRM1-Ran-RanBP1 分子名称: 3-[(4-chlorophenyl)carbonylamino]-4-[4-(2,5-dimethylphenyl)piperazin-1-yl]benzoic acid, BROMIDE ION, CHLORIDE ION, ... 著者 Sun, Q, Lei, Y. 登録日 2022-12-23 公開日 2023-12-27 最終更新日 2024-07-10 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Discovery of a Hidden Pocket beneath the NES Groove by Novel Noncovalent CRM1 Inhibitors. J.Med.Chem., 66, 2023
4DLR	H-Ras PEG 400/Ca(OAc)2, ordered off 分子名称: (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, CALCIUM ION, GTPase HRas, ... 著者 Holzapfel, G, Mattos, C. 登録日 2012-02-06 公開日 2012-08-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.319 Å) 主引用文献 Shift in the Equilibrium between On and Off States of the Allosteric Switch in Ras-GppNHp Affected by Small Molecules and Bulk Solvent Composition. Biochemistry, 51, 2012
4DLY	Set 1 CaCl2/DTT, ordered off 分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CALCIUM ION, GTPase HRas, ... 著者 Holzapfel, G, Mattos, C. 登録日 2012-02-06 公開日 2012-08-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 Shift in the Equilibrium between On and Off States of the Allosteric Switch in Ras-GppNHp Affected by Small Molecules and Bulk Solvent Composition. Biochemistry, 51, 2012
4DLT	H-Ras Set 2 Ca(OAc)2, on 分子名称: ACETATE ION, CALCIUM ION, GTPase HRas, ... 著者 Holzapfel, G, Mattos, C. 登録日 2012-02-06 公開日 2012-08-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.699 Å) 主引用文献 Shift in the Equilibrium between On and Off States of the Allosteric Switch in Ras-GppNHp Affected by Small Molecules and Bulk Solvent Composition. Biochemistry, 51, 2012
6XJT	Crystal Structure of KPT-8602 bound to CRM1 (537-DLTVK-541 to GLCEQ) 分子名称: (2R)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-2-(pyrimidin-5-yl)propanamide, Exportin-1, GTP-binding nuclear protein Ran, ... 著者 Baumhardt, J.M, Chook, Y.M. 登録日 2020-06-24 公開日 2021-01-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.406 Å) 主引用文献 Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia. J Hematol Oncol, 14, 2021
6XJP	Crystal Structure of KPT-185 bound to CRM1 (537-DLTVK-541 to GLCEQ) 分子名称: Exportin-1, GTP-binding nuclear protein Ran, MAGNESIUM ION, ... 著者 Baumhardt, J.M, Chook, Y.M. 登録日 2020-06-24 公開日 2021-01-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.802 Å) 主引用文献 Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia. J Hematol Oncol, 14, 2021
4D49	Crystal structure of computationally designed armadillo repeat proteins for modular peptide recognition. 分子名称: ARGININE, ARMADILLO REPEAT PROTEIN ARM00027, POLY ARG DECAPEPTIDE 著者 Reichen, C, Forzani, C, Zhou, T, Parmeggiani, F, Fleishman, S.J, Mittl, P.R.E, Madhurantakam, C, Honegger, A, Ewald, C, Zerbe, O, Baker, D, Caflisch, A, Pluckthun, A. 登録日 2014-10-27 公開日 2016-01-13 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition. J.Mol.Biol., 428, 2016

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