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1U9W	Crystal Structure of the Cysteine Protease Human Cathepsin K in Complex with the Covalent Inhibitor NVP-ABI491 分子名称: 9-CYCLOPENTYL-6-[2-(3-IMIDAZOL-1-YL-PROPOXY)-PHENYLAMINO]-9H-PURINE-2-CARBONITRILE, Cathepsin K 著者 Cowan-Jacob, S.W. 登録日 2004-08-11 公開日 2005-08-11 最終更新日 2017-10-11 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K J.Med.Chem., 47, 2004
1U9V	Crystal Structure of the Cysteine Protease Human Cathepsin K in Complex with the Covalent Inhibitor NVP-ABE854 分子名称: 6-(CYCLOHEXYLAMINO)-9-[2-(4-METHYLPIPERAZIN-1-YL)-ETHYL]-9H-PURINE-2-CARBONITRILE, Cathepsin K 著者 Cowan-Jacob, S.W. 登録日 2004-08-11 公開日 2005-08-11 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K J.Med.Chem., 47, 2004
1U9Q	Crystal structure of cruzain bound to an alpha-ketoester 分子名称: [1-(1-METHYL-4,5-DIOXO-PENT-2-ENYLCARBAMOYL)-2-PHENYL-ETHYL]-CARBAMIC ACID BENZYL ESTER, cruzipain 著者 Lange, M, Weston, S.G, Cheng, H, Culliane, M, Fiorey, M.M, Grisostomi, C, Hardy, L.W, Hartstough, D.S, Pallai, P.V, Tilton, R.F, Baldino, C.M, Brinen, L.S, Engel, J.C, Choe, Y, Price, M.S, Craik, C.S. 登録日 2004-08-10 公開日 2005-03-29 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Development of alpha-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease Bioorg.Med.Chem., 13, 2005
1TU6	Cathepsin K complexed with a ketoamide inhibitor 分子名称: Cathepsin K, SULFATE ION, [1-(4-FLUOROBENZYL)CYCLOBUTYL]METHYL (1S)-1-[OXO(1H-PYRAZOL-5-YLAMINO)ACETYL]PENTYLCARBAMATE 著者 Barrett, D.G, Catalano, J.G, Deaton, D.N, Hassell, A.M, Long, S.T, Miller, A.B, Miller, L.R, Shewchuk, L.M, Wells-Knecht, K.J, Wright, L.L. 登録日 2004-06-24 公開日 2004-09-21 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Potent and selective P2-P3 ketoamide inhibitors of cathepsin K with improved pharmacokinetic properties via favorable P1', P1, and/or P3 substitutions BIOORG.MED.CHEM.LETT., 14, 2004
1THE	CRYSTAL STRUCTURES OF RECOMBINANT RAT CATHEPSIN B AND A CATHEPSIN B-INHIBITOR COMPLEX: IMPLICATIONS FOR STRUCTURE-BASED INHIBITOR DESIGN 分子名称: Cathepsin B, amino{[(4S)-4-{[(benzyloxy)carbonyl]amino}-5-{[(2S)-1-(benzyloxy)-4-chloro-3-oxobutan-2-yl]amino}-5-oxopentyl]amino}met haniminium 著者 Huber, C.P, Jia, Z. 登録日 1995-09-15 公開日 1996-03-10 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structures of recombinant rat cathepsin B and a cathepsin B-inhibitor complex. Implications for structure-based inhibitor design. J.Biol.Chem., 270, 1995
1STF	THE REFINED 2.4 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF RECOMBINANT HUMAN STEFIN B IN COMPLEX WITH THE CYSTEINE PROTEINASE PAPAIN: A NOVEL TYPE OF PROTEINASE INHIBITOR INTERACTION 分子名称: PAPAIN, STEFIN B (CYSTATIN B) 著者 Stubbs, M.T, Laber, B, Bode, W. 登録日 1993-04-21 公開日 1994-01-31 最終更新日 2017-11-29 実験手法 X-RAY DIFFRACTION (2.37 Å) 主引用文献 The refined 2.4 A X-ray crystal structure of recombinant human stefin B in complex with the cysteine proteinase papain: a novel type of proteinase inhibitor interaction. EMBO J., 9, 1990
1SP4	Crystal structure of NS-134 in complex with bovine cathepsin B: a two headed epoxysuccinyl inhibitor extends along the whole active site cleft 分子名称: Cathepsin B, methyl N-[(2S)-4-{[(1S)-1-{[(2S)-2-carboxypyrrolidin-1-yl]carbonyl}-3-methylbutyl]amino}-2-hydroxy-4-oxobutanoyl]-L-leucylglycylglycinate 著者 Stern, I, Schaschke, N, Moroder, L, Turk, D. 登録日 2004-03-16 公開日 2004-05-04 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft. Biochem.J., 381, 2004
1SNK	Cathepsin K complexed with carbamate derivatized norleucine aldehyde 分子名称: Cathepsin K, N2-({[(4-BROMOPHENYL)METHYL]OXY}CARBONYL)-N1-[(1S)-1-FORMYLPENTYL]-L-LEUCINAMIDE, SULFATE ION 著者 Boros, E.E, Deaton, D.N, Hassell, A.M, McFadyen, R.B, Miller, A.B, Miller, L.R, Shewchuk, L.M, Thompson, J.B, Willard Jr, D.H, Wright, L.L. 登録日 2004-03-11 公開日 2004-06-22 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Exploration of the P(2)-P(3) SAR of aldehyde cathepsin K inhibitors Bioorg.Med.Chem.Lett., 14, 2004
1S4V	The 2.0 A crystal structure of the KDEL-tailed cysteine endopeptidase functioning in programmed cell death of Ricinus communis endosperm 分子名称: DVA-LEU-LYS-0QE peptide, SULFATE ION, cysteine endopeptidase 著者 Than, M.E, Helm, M, Simpson, D.J, Lottspeich, F, Huber, R, Gietl, C. 登録日 2004-01-19 公開日 2004-03-16 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The 2.0 A crystal structure and substrate specificity of the KDEL-tailed cysteine endopeptidase functioning in programmed cell death of Ricinus communis endosperm. J.Mol.Biol., 336, 2004
1QDQ	X-RAY CRYSTAL STRUCTURE OF BOVINE CATHEPSIN B-CA074 COMPLEX 分子名称: CATHEPSIN B, [PROPYLAMINO-3-HYDROXY-BUTAN-1,4-DIONYL]-ISOLEUCYL-PROLINE 著者 Yamamoto, A. 登録日 1999-07-10 公開日 2000-07-10 最終更新日 2018-01-31 実験手法 X-RAY DIFFRACTION (2.18 Å) 主引用文献 Substrate specificity of bovine cathepsin B and its inhibition by CA074, based on crystal structure refinement of the complex. J.Biochem.(Tokyo), 127, 2000
1Q6K	Cathepsin K complexed with t-butyl(1S)-1-cyclohexyl-2-oxoethylcarbamate 分子名称: Cathepsin K, SULFATE ION, TERT-BUTYL(1S)-1-CYCLOHEXYL-2-OXOETHYLCARBAMATE 著者 Catalano, J.G, Deaton, D.N, Furfine, E.S, Hassell, A.M, McFadyen, R.B, Miller, A.B, Miller, L.R, Shewchuk, L.M, Willard, D.H, Wright, L.L. 登録日 2003-08-13 公開日 2004-03-16 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Exploration of the P1 SAR of aldehyde cathepsin K inhibitors Bioorg.Med.Chem.Lett., 14, 2004
1PPP	CRYSTAL STRUCTURE OF PAPAIN-E64-C COMPLEX. BINDING DIVERSITY OF E64-C TO PAPAIN S2 AND S3 SUBSITES 分子名称: METHANOL, N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-2-METHYL-BUTANE, PAPAIN 著者 Ishida, T. 登録日 1993-03-17 公開日 1994-01-31 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of papain-E64-c complex. Binding diversity of E64-c to papain S2 and S3 subsites. Biochem.J., 287, 1992
1PPO	DETERMINATION OF THE STRUCTURE OF PAPAYA PROTEASE OMEGA 分子名称: MERCURY (II) ION, PROTEASE OMEGA 著者 Pickersgill, R.W, Rizkallah, P.J, Harris, G.W, Goodenough, P.W. 登録日 1991-07-12 公開日 1993-10-31 最終更新日 2017-11-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Determination of the Structure of Papaya Protease Omega Acta Crystallogr.,Sect.B, 47, 1991
1PPN	STRUCTURE OF MONOCLINIC PAPAIN AT 1.60 ANGSTROMS RESOLUTION 分子名称: METHANOL, PAPAIN, UNKNOWN LIGAND 著者 Pickersgill, R.W, Harris, G.W, Garman, E. 登録日 1991-10-25 公開日 1994-01-31 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structure of Monoclinic Papain at 1.60 Angstroms Resolution Acta Crystallogr.,Sect.B, 48, 1992
1PPD	RESTRAINED LEAST-SQUARES REFINEMENT OF THE SULFHYDRYL PROTEASE PAPAIN TO 2.0 ANGSTROMS 分子名称: 2-HYDROXYETHYL-THIOPAPAIN, BETA-MERCAPTOETHANOL 著者 Jansonius, J.N. 登録日 1984-11-06 公開日 1985-01-02 最終更新日 2017-11-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Restrained Least-Squares Refinement of the Sulfhydryl Protease Papain to 2.0 Angstroms Acta Crystallogr.,Sect.A, 40, 1984
1POP	X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A PAPAIN-LEUPEPTIN COMPLEX 分子名称: LEUPEPTIN, METHANOL, PAPAIN 著者 Schroder, E, Crawford, C. 登録日 1993-06-24 公開日 1993-10-31 最終更新日 2017-11-29 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 X-ray crystallographic structure of a papain-leupeptin complex. FEBS Lett., 315, 1993
1PIP	CRYSTAL STRUCTURE OF PAPAIN-SUCCINYL-GLN-VAL-VAL-ALA-ALA-P-NITROANILIDE COMPLEX AT 1.7 ANGSTROMS RESOLUTION: NONCOVALENT BINDING MODE OF A COMMON SEQUENCE OF ENDOGENOUS THIOL PROTEASE INHIBITORS 分子名称: Papain, SUCCINYL-GLN-VAL-VAL-ALA-ALA-P-NITROANILIDE 著者 Yamamoto, A, Tomoo, K, Doi, M, Ohishi, H, Inoue, M, Ishida, T, Yamamoto, D, Tsuboi, S, Okamoto, H, Okada, Y. 登録日 1992-10-03 公開日 1993-10-31 最終更新日 2024-04-24 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of papain-succinyl-Gln-Val-Val-Ala-Ala-p-nitroanilide complex at 1.7-A resolution: noncovalent binding mode of a common sequence of endogenous thiol protease inhibitors. Biochemistry, 31, 1992
1PE6	REFINED X-RAY STRUCTURE OF PAPAIN(DOT)E-64-C COMPLEX AT 2.1-ANGSTROMS RESOLUTION 分子名称: METHANOL, N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-2-METHYL-BUTANE, PAPAIN 著者 Yamamoto, D, Matsumoto, K, Ohishi, H, Ishida, T, Inoue, M, Kitamura, K, Mizuno, H. 登録日 1991-05-14 公開日 1993-04-15 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Refined x-ray structure of papain.E-64-c complex at 2.1-A resolution. J.Biol.Chem., 266, 1991
1PCI	PROCARICAIN 分子名称: PROCARICAIN 著者 Groves, M.R, Taylor, M.A.J, Scott, M, Cummings, N.J, Pickersgill, R.W, Jenkins, J.A. 登録日 1996-06-28 公開日 1997-04-01 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 The prosequence of procaricain forms an alpha-helical domain that prevents access to the substrate-binding cleft. Structure, 4, 1996
1PBH	CRYSTAL STRUCTURE OF HUMAN RECOMBINANT PROCATHEPSIN B AT 3.2 ANGSTROM RESOLUTION 分子名称: PROCATHEPSIN B 著者 Podobnik, M, Turk, D. 登録日 1997-02-14 公開日 1998-02-25 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Crystal structures of human procathepsin B at 3.2 and 3.3 Angstroms resolution reveal an interaction motif between a papain-like cysteine protease and its propeptide. FEBS Lett., 384, 1996
1PAD	Binding of chloromethyl ketone substrate analogues to crystalline papain 分子名称: ACETYL-ALA-ALA-PHE-ALA-CHLOROMETHYLKETONE INHIBITOR, PAPAIN 著者 Drenth, J, Kalk, K.H, Swen, H.M. 登録日 1976-11-01 公開日 1977-04-12 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Binding of chloromethyl ketone substrate analogues to crystalline papain. Biochemistry, 15, 1976
1O0E	1.9 Angstrom Crystal Structure of a plant cysteine protease Ervatamin C 分子名称: Ervatamin C, THIOSULFATE 著者 Thakurta, P.G, Chakrabarti, C, Biswas, S, Dattagupta, J.K. 登録日 2003-02-21 公開日 2004-03-02 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Basis of the Unusual Stability and Substrate Specificity of Ervatamin C, a Plant Cysteine Protease from Ervatamia coronaria Biochemistry, 43, 2004
1NQC	Crystal structures of Cathepsin S inhibitor complexes 分子名称: Cathepsin S, N-[(1R)-2-(BENZYLSULFANYL)-1-FORMYLETHYL]-N-(MORPHOLIN-4-YLCARBONYL)-L-PHENYLALANINAMIDE 著者 Pauly, T.A, Sulea, T, Ammirati, M, Sivaraman, J, Danley, D.E, Griffor, M.C, Kamath, A.V, Wang, I.K, Laird, E.R, Menard, R, Cygler, M, Rath, V.L. 登録日 2003-01-21 公開日 2003-04-15 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Specificity determinants of human cathepsin s revealed by crystal structures of complexes. Biochemistry, 42, 2003
1NPZ	Crystal structures of Cathepsin S inhibitor complexes 分子名称: Cathepsin S, N~2~-(morpholin-4-ylcarbonyl)-N-[(3S)-1-phenyl-5-(phenylsulfonyl)pentan-3-yl]-L-leucinamide 著者 Pauly, T.A, Sulea, T, Ammirati, M, Sivaraman, J, Danley, D.E, Griffor, M.C, Kamath, A.V, Wang, I.K, Laird, E.R, Seddon, A.P, Menard, R, Cygler, M, Rath, V.L. 登録日 2003-01-20 公開日 2003-04-15 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Specificity determinants of human cathepsin s revealed by crystal structures of complexes. Biochemistry, 42, 2003
1NLJ	CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT AZEPANONE INHIBITOR 分子名称: BENZOFURAN-2-CARBOXYLIC ACID {(S)-3-METHYL-1-[3-OXO-1-(PYRIDIN-2-YLSULFONYL)AZEPAN-4-YLCARBAMOYL]BUTYL}AMIDE, CATHEPSIN K 著者 Smith, W.W, Janson, C.A, Zhao, B. 登録日 2003-01-07 公開日 2003-01-14 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Azepanone-Based Inhibitors of Human and Rat Cathepsin K J.Med.Chem., 44, 2001

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