PDB: 41454 件ウェブページステータス検索Chemie searchBIRD

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8TCG	Integrin alpha-v beta-6 in complex with minibinder B6_BP_dslf 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Integrin alpha-V heavy chain, ... 著者 Campbell, M.G, Fernandez, A, Roy, A, Kraft, J, Baker, D. 登録日 2023-06-30 公開日 2023-09-27 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 De novo design of highly selective miniprotein inhibitors of integrins alpha v beta 6 and alpha v beta 8. Nat Commun, 14, 2023
4G67	Crystal structure of a COG1565 superfamily member and likely methyl transferase from Burkholderia thailandensis bound to S-adenosyl-homocysteine 分子名称: 1,2-ETHANEDIOL, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2012-07-18 公開日 2012-08-01 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Combining functional and structural genomics to sample the essential Burkholderia structome. Plos One, 8, 2013
8SSH	MtrR from Neisseria gonorrhoeae bound to Ethinyl Estradiol 分子名称: Ethinyl estradiol, HTH-type transcriptional regulator MtrR, PHOSPHATE ION 著者 Hooks, G.M, Brennan, R.G. 登録日 2023-05-08 公開日 2024-02-14 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Hormonal steroids induce multidrug resistance and stress response genes in Neisseria gonorrhoeae by binding to MtrR. Nat Commun, 15, 2024
8SY2	Peanut USP-type BURP Domain Peptide Cyclase 分子名称: BURP domain-containing protein 著者 Mydy, L.S, Kersten, R.D, Smith, J.L. 登録日 2023-05-24 公開日 2024-02-14 最終更新日 2024-04-10 実験手法 X-RAY DIFFRACTION (2.67 Å) 主引用文献 An intramolecular macrocyclase in plant ribosomal peptide biosynthesis. Nat.Chem.Biol., 20, 2024
8SY3	Copper Complex of Peanut USP-type BURP Domain Peptide Cyclase 分子名称: BURP domain-containing protein, COPPER (II) ION 著者 Mydy, L.S, Kersten, R.D, Smith, J.L. 登録日 2023-05-24 公開日 2024-02-14 最終更新日 2024-04-10 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 An intramolecular macrocyclase in plant ribosomal peptide biosynthesis. Nat.Chem.Biol., 20, 2024
8T2N	Crystal structure of GABARAP in complex with the LIR of NSs3 分子名称: Gamma-aminobutyric acid receptor-associated protein, Non-structural protein S 著者 Ali, M.G.H, Wahba, H.M, Cyr, N, Omichinski, J.G. 登録日 2023-06-06 公開日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 An LIR motif in the Rift Valley fever virus NSs protein is critical for the interaction with LC3 family members and inhibition of autophagy. Plos Pathog., 20, 2024
8T2M	Crystal structure of GABARAP in complex with the LIR of NSs4 分子名称: Non-structural protein S,Gamma-aminobutyric acid receptor-associated protein chimera 著者 Ali, M.G.H, Wahba, H.M, Cyr, N, Omichinski, J.G. 登録日 2023-06-06 公開日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.27 Å) 主引用文献 An LIR motif in the Rift Valley fever virus NSs protein is critical for the interaction with LC3 family members and inhibition of autophagy. Plos Pathog., 20, 2024
8T2L	Crystal structure of LC3A in complex with the LIR of NSs4 分子名称: Non-structural protein S,Microtubule-associated proteins 1A/1B light chain 3A chimera 著者 Ali, M.G.H, Wahba, H.M, Cyr, N, Omichinski, J.G. 登録日 2023-06-06 公開日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 An LIR motif in the Rift Valley fever virus NSs protein is critical for the interaction with LC3 family members and inhibition of autophagy. Plos Pathog., 20, 2024
4WPB	Vascular endothelial growth factor in complex with alpha/beta-VEGF-1 分子名称: Vascular endothelial growth factor A, alpha/beta-VEGF-1 著者 Kreitler, D.F, Checco, J.W, Gellman, S.H, Forest, K.T. 登録日 2014-10-17 公開日 2015-04-15 最終更新日 2024-07-10 実験手法 X-RAY DIFFRACTION (3.11 Å) 主引用文献 Targeting diverse protein-protein interaction interfaces with alpha / beta-peptides derived from the Z-domain scaffold. Proc.Natl.Acad.Sci.USA, 112, 2015
5XYF	Crystal structure of the human TIN2-TPP1-TRF2 telomeric complex 分子名称: Adrenocortical dysplasia protein homolog, TERF1-interacting nuclear factor 2, Telomeric repeat-binding factor 2 著者 Hu, C, Chen, Y. 登録日 2017-07-07 公開日 2017-12-13 実験手法 X-RAY DIFFRACTION (2.202 Å) 主引用文献 Structural and functional analyses of the mammalian TIN2-TPP1-TRF2 telomeric complex. Cell Res., 27, 2017
7D4B	Crystal structure of 4-1BB in complex with a VHH 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... 著者 Wang, C. 登録日 2020-09-23 公開日 2021-07-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.14 Å) 主引用文献 Generation of a safe and efficacious llama single-domain antibody fragment (vHH) targeting the membrane-proximal region of 4-1BB for engineering therapeutic bispecific antibodies for cancer. J Immunother Cancer, 9, 2021
7ZJQ	Human TEAD3 in complex with 1-Cyclopentyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 分子名称: 1-cyclopentylpyrazolo[3,4-b]pyridine-5-carboxylic acid, Transcriptional enhancer factor TEF-5 著者 Musil, D, Sousa, C.M. 登録日 2022-04-11 公開日 2022-07-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.095 Å) 主引用文献 Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead MSC-4106 . J.Med.Chem., 65, 2022
7ZS6	Crystal structure of Apis mellifera RidA 分子名称: 1,2-ETHANEDIOL, MAGNESIUM ION, Reactive intermediate deaminase A, ... 著者 Visentin, C, Rizzi, G, Ricagno, S. 登録日 2022-05-06 公開日 2022-07-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.31 Å) 主引用文献 Apis mellifera RidA, a novel member of the canonical YigF/YER057c/UK114 imine deiminase superfamily of enzymes pre-empting metabolic damage. Biochem.Biophys.Res.Commun., 616, 2022
4XKX	Crystal structure of BACE1 in complex with 2-aminooxazoline 3-azaxanthene inhibitor 28 分子名称: (5S)-7-(2-fluoropyridin-3-yl)-3-(2-fluoropyridin-4-yl)spiro[chromeno[2,3-c]pyridine-5,4'-[1,3]oxazol]-2'-amine, Beta-secretase 1, GLYCEROL, ... 著者 Whittington, D.A, Long, A.M. 登録日 2015-01-12 公開日 2015-02-04 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious beta-secretase inhibitors for the potential treatment of Alzheimer's disease. Bioorg.Med.Chem.Lett., 25, 2015
8UKE	Crystal Structure of Norbelladine O-methyltransferase variant in complex with SAH 分子名称: CALCIUM ION, Norbelladine 4'-O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE 著者 Kim, W, Zhang, Y.J. 登録日 2023-10-12 公開日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Biosensor and machine learning-aided engineering of an amaryllidaceae enzyme. Nat Commun, 15, 2024
7BNQ	Lateral-closed conformation of the lid-locked BAM complex (BamA E435C S665C, BamBDCE) by cryoEM 分子名称: Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ... 著者 Haysom, S.F. 登録日 2021-01-22 公開日 2021-06-02 最終更新日 2021-07-21 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 The role of membrane destabilisation and protein dynamics in BAM catalysed OMP folding. Nat Commun, 12, 2021
6BEK	Structure of sIHF bound to an 8bp palindromic DNA 分子名称: DNA (5'-D(*CP*AP*TP*GP*CP*AP*TP*G)-3'), POTASSIUM ION, SCO1480 著者 Guarne, A, Nanji, T.N, Shen, Y. 登録日 2017-10-25 公開日 2018-10-31 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Streptomyces IHF uses multiple interfaces to bind DNA. Biochim Biophys Acta Gen Subj, 1863, 2019
6BAW	Structure of GRP94 with a selective resorcinylic inhibitor. 分子名称: 1,2-ETHANEDIOL, Endoplasmin, PHOSPHATE ION, ... 著者 Que, N.L.S, Gewirth, D.T. 登録日 2017-10-16 公開日 2018-04-18 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.703 Å) 主引用文献 Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding. J. Med. Chem., 61, 2018
1B87	CRYSTAL STRUCTURE OF AN AMINOGLYCOSIDE 6'-N-ACETYLTRANSFERASE 分子名称: ACETYL COENZYME *A, PROTEIN (AMINOGLYCOSIDE N6'-ACETYLTRANSFERASE TYPE 1) 著者 Wybenga-Groot, L.E, Berghuis, A.M. 登録日 1999-02-09 公開日 1999-06-30 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of an aminoglycoside 6'-N-acetyltransferase: defining the GCN5-related N-acetyltransferase superfamily fold. Structure Fold.Des., 7, 1999
6C91	Structure of GRP94 with a resorcinylic inhibitor. 分子名称: 1,2-ETHANEDIOL, 5-[2-(1-benzyl-1H-imidazol-2-yl)ethyl]-4,6-dichlorobenzene-1,3-diol, Endoplasmin, ... 著者 Que, N.L.S, Gewirth, D.T. 登録日 2018-01-25 公開日 2018-04-18 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.895 Å) 主引用文献 Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding. J. Med. Chem., 61, 2018
7FDW	Crystal structure of pepsin cleaved lactoferrin C-lobe at 2.28 A resolution 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CARBONATE ION, FE (III) ION, ... 著者 Singh, P.K, Singh, J, Maurya, A, Sharma, P, Sharma, S, Singh, T.P. 登録日 2021-07-18 公開日 2021-08-04 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.277 Å) 主引用文献 A Peptide Bond from the Inter-lobe Segment in the Bilobal Lactoferrin Acts as a Preferred Site for Cleavage for Serine Proteases to Generate the Perfect C-lobe: Structure of the Pepsin Hydrolyzed Lactoferrin C-lobe at 2.28 angstrom Resolution. Protein J., 40, 2021
1AFS	RECOMBINANT RAT LIVER 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (3-ALPHA-HSD) COMPLEXED WITH NADP AND TESTOSTERONE 分子名称: 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TESTOSTERONE 著者 Bennett, M.J, Albert, R.H, Jez, J.M, Ma, H, Penning, T.M, Lewis, M. 登録日 1997-03-13 公開日 1997-10-08 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Steroid recognition and regulation of hormone action: crystal structure of testosterone and NADP+ bound to 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase. Structure, 5, 1997
1OSG	Complex between BAFF and a BR3 derived peptide presented in a beta-hairpin scaffold 分子名称: BR3 derived PEPTIDE, MAGNESIUM ION, Tumor necrosis factor ligand superfamily member 13B 著者 Gordon, N.C, Pan, B, Hymowitz, S.G, Yin, J.P, Kelley, R.F, Cochran, A.G, Yan, M, Dixit, V.M, Fairbrother, W.J, Starovasnik, M.A. 登録日 2003-03-19 公開日 2003-05-27 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site Biochemistry, 42, 2003
6CEO	Structure of Hsp90 NTD with a GRP94-selective resorcinylic inhibitor. 分子名称: 1,2-ETHANEDIOL, Heat shock protein HSP 90-alpha, MAGNESIUM ION, ... 著者 Que, N.L.S, Gewirth, D.T. 登録日 2018-02-12 公開日 2018-04-18 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.896 Å) 主引用文献 Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding. J. Med. Chem., 61, 2018
8UM2	Carboxy terminus of Oleate Hydratase in phosphate buffer 分子名称: Myosin-cross-reactive antigen 著者 Grace, C.R, Radka, C. 登録日 2023-10-17 公開日 2024-01-31 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 The carboxy terminus causes interfacial assembly of oleate hydratase on a membrane bilayer. J.Biol.Chem., 300, 2024

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