7ZJQ

Human TEAD3 in complex with 1-Cyclopentyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid

Summary for 7ZJQ

• Entry DOI: 10.2210/pdb7zjq/pdb
• Descriptor: Transcriptional enhancer factor TEF-5, 1-cyclopentylpyrazolo[3,4-b]pyridine-5-carboxylic acid, ... (4 entities in total)
• Functional Keywords: immunoglobulin-like fold, activator, disease mutation, dna-binding, nucleus, phosphoprotein, transcription, transcription regulation, transcription-protein binding complex
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 102176.16

Authors

Musil, D.,Sousa, C.M. (deposition date: 2022-04-11, release date: 2022-07-13, Last modification date: 2024-01-31)

• Primary citation: Heinrich, T.,Peterson, C.,Schneider, R.,Garg, S.,Schwarz, D.,Gunera, J.,Seshire, A.,Kotzner, L.,Schlesiger, S.,Musil, D.,Schilke, H.,Doerfel, B.,Diehl, P.,Bopple, P.,Lemos, A.R.,Sousa, P.M.F.,Freire, F.,Bandeiras, T.M.,Carswell, E.,Pearson, N.,Sirohi, S.,Hooker, M.,Trivier, E.,Broome, R.,Balsiger, A.,Crowden, A.,Dillon, C.,Wienke, D.; Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead MSC-4106 .; J.Med.Chem., 65:9206-9229, 2022; PubMed: 35763499; DOI: 10.1021/acs.jmedchem.2c00403

Experimental method

X-RAY DIFFRACTION (2.095 Å)