2O5S
| Cobalt horse heart myoglobin, nitrite modified | 分子名称: | Myoglobin, NITRITE ION, PROTOPORPHYRIN IX CONTAINING CO, ... | 著者 | Richter-Addo, G.B, Zahran, Z.N, Chooback, L, Copeland, D.M, West, A.H. | 登録日 | 2006-12-06 | 公開日 | 2007-10-16 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystal structures of manganese- and cobalt-substituted myoglobin in complex with NO and nitrite reveal unusual ligand conformations. J.Inorg.Biochem., 102, 2008
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4LSJ
| Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Bound to a Dibenzoxapine Sulfonamide | 分子名称: | D30 peptide, Glucocorticoid receptor, N-{3-[(1Z)-1-(10-methoxydibenzo[b,e]oxepin-11(6H)-ylidene)propyl]phenyl}methanesulfonamide | 著者 | Carson, M, Luz, J.G, Clawson, D, Coghlan, M. | 登録日 | 2013-07-22 | 公開日 | 2014-01-29 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Glucocorticoid receptor modulators informed by crystallography lead to a new rationale for receptor selectivity, function, and implications for structure-based design. J.Med.Chem., 57, 2014
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7NE7
| oligopeptidase B from S. proteomaculans with modified hinge region in complex with N-[(1S)-5-amino-1-(chloroacetyl)pentyl]-4-methylbenzenesulfonamide | 分子名称: | N-[(1S)-5-amino-1-(chloroacetyl)pentyl]-4-methylbenzenesulfonamide, Oligopeptidase B, SPERMINE | 著者 | Petrenko, D.E, Nikolaeva, A.Y, Lazarenko, V.A, Dorovatovskiy, P.V, Vlaskina, A.V, Mikhailova, A.G, Rakitina, T.V, Timofeev, V.I. | 登録日 | 2021-02-03 | 公開日 | 2021-02-17 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The Crystal Structure of N alpha-p-tosyl-lysyl Chloromethylketone-Bound Oligopeptidase B from Serratia Proteamaculans Revealed a New Type of Inhibitor Binding Crystals, 11, 2021
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3P2T
| Crystal Structure of Leukocyte Ig-like Receptor LILRB4 (ILT3/LIR-5/CD85k) | 分子名称: | Leukocyte immunoglobulin-like receptor subfamily B member 4, SULFATE ION | 著者 | Chen, Y, Nam, G, Cheng, H, Zhang, J.H, Willcox, B.E, Gao, G.F. | 登録日 | 2010-10-04 | 公開日 | 2011-03-30 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.699 Å) | 主引用文献 | Crystal structure of leukocyte Ig-like receptor LILRB4 (ILT3/LIR-5/CD85k): a myeloid inhibitory receptor involved in immune tolerance J.Biol.Chem., 286, 2011
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3UJT
| Structure of the Fab fragment of Ab-52, an antibody that binds the O-antigen of Francisella tularensis | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Ab-52 heavy chain, Ab-52 light chain, ... | 著者 | Rynkiewicz, M.J, Lu, Z, Hui, J.H, Sharon, J, Seaton, B.A. | 登録日 | 2011-11-08 | 公開日 | 2012-07-25 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural Analysis of a Protective Epitope of the Francisella tularensis O-Polysaccharide. Biochemistry, 51, 2012
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6CAF
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1DWV
| MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER N-hydroxyarginine and 4-amino tetrahydrobiopterin | 分子名称: | 2,4-DIAMINO-6-[2,3-DIHYDROXY-PROP-3-YL]-5,6,7,8-TETRAHYDROPTERIDINE, N-OMEGA-HYDROXY-L-ARGININE, NITRIC OXIDE SYNTHASE, ... | 著者 | Crane, B.R, Arvai, A.S, Getzoff, E.D, Stuehr, D.J, Tainer, J.A. | 登録日 | 1999-12-14 | 公開日 | 2000-02-06 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structures of the N(Omega)-Hydroxy-L-Arginine Complex of Inducible Nitric Oxide Synthase Oxygenase Dimer with Active Andinactive Pterins Biochemistry, 39, 2000
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3URC
| T181G mutant of alpha-Lytic Protease | 分子名称: | Alpha-lytic protease, GLYCEROL, SULFATE ION | 著者 | Kelch, B.A, Agard, D.A. | 登録日 | 2011-11-22 | 公開日 | 2012-05-23 | 最終更新日 | 2019-07-17 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Functional modulation of a protein folding landscape via side-chain distortion. Proc.Natl.Acad.Sci.USA, 109, 2012
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3P5Q
| Ferric R-state human aquomethemoglobin | 分子名称: | Hemoglobin subunit alpha, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Yi, J, Thomas, L.M, Richter-Addo, G.B. | 登録日 | 2010-10-10 | 公開日 | 2011-06-08 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of human R-state aquomethemoglobin at 2.0 A resolution Acta Crystallogr.,Sect.F, 67, 2011
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3K54
| Structures of human Bruton's tyrosine kinase in active and inactive conformations suggests a mechanism of activation for TEC family kinases. | 分子名称: | N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, Tyrosine-protein kinase BTK | 著者 | Marcotte, D.J, Liu, Y.-T, Arduini, R.M, Hession, C.A, Miatkowski, K, Wildes, C.P, Cullen, P.F, Hopkins, B.T, Mertsching, E, Jenkins, T.J, Romanowski, M.J, Baker, D.P, Silvian, L.F. | 登録日 | 2009-10-06 | 公開日 | 2010-01-19 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases. Protein Sci., 19, 2010
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6R2G
| Crystal structure of a single-chain protein mimetic of the gp41 NHR trimer in complex with the synthetic CHR peptide C34 | 分子名称: | Envelope glycoprotein gp160, PHOSPHATE ION, Single-chain protein mimetics of the N-terminal heptad-repeat region of gp41 | 著者 | Camara-Artigas, A, Conejero-Lara, F, Jurado, S, Cano-Munoz, M, Morel, B. | 登録日 | 2019-03-17 | 公開日 | 2019-07-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural and Thermodynamic Analysis of HIV-1 Fusion Inhibition Using Small gp41 Mimetic Proteins. J.Mol.Biol., 431, 2019
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1JL9
| Crystal Structure of Human Epidermal Growth Factor | 分子名称: | EPIDERMAL GROWTH FACTOR | 著者 | Lu, H.S, Chai, J.J, Li, M, Huang, B.R, He, C.H, Bi, R.C. | 登録日 | 2001-07-16 | 公開日 | 2001-10-24 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal structure of human epidermal growth factor and its dimerization J.Biol.Chem., 276, 2001
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6TOJ
| Crystal structure of human BCL6 BTB domain in complex with compound 17a | 分子名称: | 1,2-ETHANEDIOL, 2-chloranyl-4-[[1-methyl-3-(3-methyl-3-oxidanyl-butyl)-2-oxidanylidene-benzimidazol-5-yl]amino]pyridine-3-carbonitrile, B-cell lymphoma 6 protein | 著者 | Rodrigues, M.J, Le Bihan, Y.-V, van Montfort, R.L.M. | 登録日 | 2019-12-11 | 公開日 | 2020-04-22 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | AchievingIn VivoTarget Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders. J.Med.Chem., 63, 2020
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6C1S
| Phosphoinositide 3-Kinase gamma bound to an pyrrolopyridinone Inhibitor | 分子名称: | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, {4-[2-(5,6-dimethoxypyridin-3-yl)-5-oxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-1H-pyrazol-1-yl}acetonitrile | 著者 | Jacobs, M.D, Griffin, J.P. | 登録日 | 2018-01-05 | 公開日 | 2018-06-27 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3-Kinase gamma (PI3K gamma ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS). J. Med. Chem., 61, 2018
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6R7I
| Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome | 分子名称: | COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ... | 著者 | Faull, S.F, Lau, A.M.C, Beuron, F, Cronin, N.B, Morris, E.P, Politis, A. | 登録日 | 2019-03-28 | 公開日 | 2019-08-28 | 最終更新日 | 2019-09-04 | 実験手法 | ELECTRON MICROSCOPY (5.9 Å) | 主引用文献 | Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome. Nat Commun, 10, 2019
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6CHE
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5EHA
| Crystal structure of recombinant MtaL at 1.35 Angstrom resolution | 分子名称: | Lectin-like fold protein | 著者 | Lai, X.-L, Soler-Lopez, M, Wichers, H.J, Dijkstra, B.W. | 登録日 | 2015-10-28 | 公開日 | 2016-03-09 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Crystal structure of recombinant tyrosinase-binding protein MtaL at 1.35 angstrom resolution. Acta Crystallogr.,Sect.F, 72, 2016
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6XIG
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5D00
| Crystal structure of BshA from B. subtilis complexed with N-acetylglucosaminyl-malate and UMP | 分子名称: | (2S)-2-{[2-acetamido-2-deoxy-alpha-D-glucopyranosyl]oxy}butanedioic acid, N-acetyl-alpha-D-glucosaminyl L-malate synthase, PHOSPHATE ION, ... | 著者 | Cook, P.D, Winchell, K.R. | 登録日 | 2015-08-01 | 公開日 | 2016-09-07 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | A Structural, Functional, and Computational Analysis of BshA, the First Enzyme in the Bacillithiol Biosynthesis Pathway. Biochemistry, 55, 2016
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5E9T
| Crystal structure of GtfA/B complex | 分子名称: | Glycosyltransferase Gtf1, Glycosyltransferase-stabilizing protein Gtf2, MAGNESIUM ION | 著者 | Chen, Y, Rapoport, T.A. | 登録日 | 2015-10-15 | 公開日 | 2016-03-02 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.92 Å) | 主引用文献 | Mechanism of a cytosolic O-glycosyltransferase essential for the synthesis of a bacterial adhesion protein. Proc.Natl.Acad.Sci.USA, 113, 2016
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5YS6
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3Q8E
| Crystal structure of Protective Antigen W346F (pH 8.5) | 分子名称: | CALCIUM ION, Protective antigen | 著者 | Lovell, S, Battaile, K.P, Rajapaksha, M, Janowiak, B.E, Andra, K.K, Bann, J.G. | 登録日 | 2011-01-06 | 公開日 | 2012-02-15 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.098 Å) | 主引用文献 | pH effects on binding between the anthrax protective antigen and the host cellular receptor CMG2. Protein Sci., 21, 2012
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8R55
| Bacillus subtilis MutS2-collided disome complex (collided 70S) | 分子名称: | 16S rRNA (1533-MER), 23S RNA (2887-MER), 30S ribosomal protein S10, ... | 著者 | Park, E, Mackens-Kiani, T, Berhane, R, Esser, H, Erdenebat, C, Burroughs, A.M, Berninghausen, O, Aravind, L, Beckmann, R, Green, R, Buskirk, A.R. | 登録日 | 2023-11-16 | 公開日 | 2024-01-17 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.57 Å) | 主引用文献 | B. subtilis MutS2 splits stalled ribosomes into subunits without mRNA cleavage. Embo J., 43, 2024
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7PPF
| CRYSTAL STRUCTURE OF NAMPT IN COMPLEX WITH COMPOUND 8 | 分子名称: | 1,2-ETHANEDIOL, N-[4-[(4R)-1,4-dimethyl-6-oxidanylidene-4,5-dihydropyridazin-3-yl]phenyl]-5,7-dihydropyrrolo[3,4-b]pyridine-6-carboxamide, Nicotinamide phosphoribosyltransferase, ... | 著者 | Hillig, R.C. | 登録日 | 2021-09-13 | 公開日 | 2022-06-15 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | 主引用文献 | A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy. Bioconjug.Chem., 33, 2022
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3P0Q
| Human Tankyrase 2 - Catalytic PARP domain in complex with an inhibitor | 分子名称: | N-[2-(4-chlorophenyl)ethyl]-6-methyl[1,2,4]triazolo[4,3-b]pyridazin-8-amine, SODIUM ION, SULFATE ION, ... | 著者 | Karlberg, T, Siponen, M.I, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, I, Kotenyova, T, Kouznetsova, E, Moche, M, Nordlund, P, Nyman, T, Persson, C, Schutz, P, Sehic, A, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Wahlberg, E, Weigelt, J, Welin, M, Schuler, H, Structural Genomics Consortium (SGC) | 登録日 | 2010-09-29 | 公開日 | 2010-10-20 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors Nat.Biotechnol., 30, 2012
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