3P0Q
Human Tankyrase 2 - Catalytic PARP domain in complex with an inhibitor
Summary for 3P0Q
Entry DOI | 10.2210/pdb3p0q/pdb |
Related | 3KR7 3P0N 3P0P |
Descriptor | Tankyrase-2, ZINC ION, N-[2-(4-chlorophenyl)ethyl]-6-methyl[1,2,4]triazolo[4,3-b]pyridazin-8-amine, ... (6 entities in total) |
Functional Keywords | protein-ligand complex, structural genomics, structural genomics consortium, sgc, diphtheria toxin like fold, transferase, nad+, adp-ribosylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q9H2K2 |
Total number of polymer chains | 2 |
Total formula weight | 55736.07 |
Authors | Karlberg, T.,Siponen, M.I.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, I.,Kotenyova, T.,Kouznetsova, E.,Moche, M.,Nordlund, P.,Nyman, T.,Persson, C.,Schutz, P.,Sehic, A.,Thorsell, A.G.,Tresaugues, L.,Van Den Berg, S.,Wahlberg, E.,Weigelt, J.,Welin, M.,Schuler, H.,Structural Genomics Consortium (SGC) (deposition date: 2010-09-29, release date: 2010-10-20, Last modification date: 2023-11-01) |
Primary citation | Wahlberg, E.,Karlberg, T.,Kouznetsova, E.,Markova, N.,Macchiarulo, A.,Thorsell, A.G.,Pol, E.,Frostell, A.,Ekblad, T.,Kull, B.,Robertson, G.M.,Pellicciari, R.,Schuler, H.,Weigelt, J. Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors Nat.Biotechnol., 30:283-288, 2012 Cited by PubMed: 22343925DOI: 10.1038/nbt.2121 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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