3P0Q

Human Tankyrase 2 - Catalytic PARP domain in complex with an inhibitor

Summary for 3P0Q

• Entry DOI: 10.2210/pdb3p0q/pdb
• Related: 3KR7 3P0N 3P0P
• Descriptor: Tankyrase-2, ZINC ION, N-[2-(4-chlorophenyl)ethyl]-6-methyl[1,2,4]triazolo[4,3-b]pyridazin-8-amine, ... (6 entities in total)
• Functional Keywords: protein-ligand complex, structural genomics, structural genomics consortium, sgc, diphtheria toxin like fold, transferase, nad+, adp-ribosylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q9H2K2
• Total number of polymer chains: 2
• Total formula weight: 55736.07

Authors

Karlberg, T.,Siponen, M.I.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, I.,Kotenyova, T.,Kouznetsova, E.,Moche, M.,Nordlund, P.,Nyman, T.,Persson, C.,Schutz, P.,Sehic, A.,Thorsell, A.G.,Tresaugues, L.,Van Den Berg, S.,Wahlberg, E.,Weigelt, J.,Welin, M.,Schuler, H.,Structural Genomics Consortium (SGC) (deposition date: 2010-09-29, release date: 2010-10-20, Last modification date: 2023-11-01)

• Primary citation: Wahlberg, E.,Karlberg, T.,Kouznetsova, E.,Markova, N.,Macchiarulo, A.,Thorsell, A.G.,Pol, E.,Frostell, A.,Ekblad, T.,Kull, B.,Robertson, G.M.,Pellicciari, R.,Schuler, H.,Weigelt, J.; Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors; Nat.Biotechnol., 30:283-288, 2012; PubMed: 22343925; DOI: 10.1038/nbt.2121

Experimental method

X-RAY DIFFRACTION (1.9 Å)