3P0Q

Human Tankyrase 2 - Catalytic PARP domain in complex with an inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity
C	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1

Chain	Residue
A	CYS1081
A	HIS1084
A	CYS1089
A	CYS1092

---

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE NNL A 1163

Chain	Residue
A	ALA1049
A	TYR1050
A	TYR1060
A	SER1068
A	TYR1071
A	ILE1075
A	HOH280
A	PHE1030
A	HIS1031
A	GLY1032
A	PRO1034

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 1164

Chain	Residue
A	HOH128
A	HOH235
A	HOH240
A	ARG977
A	HIS979
A	ARG980
A	LYS1067
A	GLN1070

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 3

Chain	Residue
A	HOH47
A	HOH175
A	ASN990
A	ARG991
A	GLU1161

---

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE NA A 5

Chain	Residue
A	SER1118

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 1

Chain	Residue
C	CYS1081
C	HIS1084
C	CYS1089
C	CYS1092

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE NNL C 2

Chain	Residue
C	PHE1030
C	HIS1031
C	GLY1032
C	PRO1034
C	ALA1049
C	TYR1060
C	ALA1062
C	SER1068
C	TYR1071

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 1163

Chain	Residue
C	HOH219
C	HOH270
C	ARG977
C	HIS979
C	ARG980
C	LYS1067
C	GLN1070

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 C 4

Chain	Residue
C	HOH64
C	HOH252
C	ASN990
C	ARG991
C	PRO1160
C	GLU1161

---

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE NA C 6

Chain	Residue
C	SER1118

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"O95271","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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