8D5V
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![BU of 8d5v by Molmil](/molmil-images/mine/8d5v) | WhiB6 bound to the SigmaAr4-RNAP Beta flap tip chimera | 分子名称: | IRON/SULFUR CLUSTER, Probable transcriptional regulator WhiB6, RNA polymerase sigma factor SigA,DNA-directed RNA polymerase subunit beta | 著者 | Wan, T, Zhang, L.M. | 登録日 | 2022-06-06 | 公開日 | 2023-06-14 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of WhiB6 and SigA4-betaTip complex To Be Published
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8QLL
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![BU of 8qll by Molmil](/molmil-images/mine/8qll) | |
6VEL
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![BU of 6vel by Molmil](/molmil-images/mine/6vel) | |
8RD1
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![BU of 8rd1 by Molmil](/molmil-images/mine/8rd1) | HUWE1 WWE domain in complex with compound 4 | 分子名称: | 2-(2-hydroxy-2-oxoethyl)-1,3-bis(oxidanylidene)isoindole-5-carboxylic acid, CHLORIDE ION, E3 ubiquitin-protein ligase HUWE1 | 著者 | Muenzker, L, Zak, K.M, Boettcher, J. | 登録日 | 2023-12-07 | 公開日 | 2024-07-31 | 最終更新日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (1.896 Å) | 主引用文献 | A ligand discovery toolbox for the WWE domain family of human E3 ligases. Commun Biol, 7, 2024
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8RD7
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![BU of 8rd7 by Molmil](/molmil-images/mine/8rd7) | HUWE1 WWE domain in complex with ADP-ribose | 分子名称: | ACETATE ION, CHLORIDE ION, E3 ubiquitin-protein ligase HUWE1, ... | 著者 | Muenzker, L, Zak, K.M, Boettcher, J. | 登録日 | 2023-12-07 | 公開日 | 2024-07-31 | 最終更新日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | 主引用文献 | A ligand discovery toolbox for the WWE domain family of human E3 ligases. Commun Biol, 7, 2024
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8R1O
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![BU of 8r1o by Molmil](/molmil-images/mine/8r1o) | Structure of C. thermophilum RNA exosome core | 分子名称: | Exoribonuclease phosphorolytic domain-containing protein, Exoribonuclease-like protein, Exosome complex component MTR3, ... | 著者 | Lazzaretti, D, Liebau, J, Pilsl, M, Sprangers, R. | 登録日 | 2023-11-02 | 公開日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | 主引用文献 | Beyond static structures: quantitative dynamics in the eukaryotic RNA exosome complex Biorxiv, 2024
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8RD0
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![BU of 8rd0 by Molmil](/molmil-images/mine/8rd0) | HUWE1 WWE domain in complex with compound 3 | 分子名称: | (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetic acid, CHLORIDE ION, E3 ubiquitin-protein ligase HUWE1 | 著者 | Muenzker, L, Boettcher, J. | 登録日 | 2023-12-07 | 公開日 | 2024-07-31 | 最終更新日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (1.765 Å) | 主引用文献 | A ligand discovery toolbox for the WWE domain family of human E3 ligases. Commun Biol, 7, 2024
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6UWF
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![BU of 6uwf by Molmil](/molmil-images/mine/6uwf) | |
6UWW
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![BU of 6uww by Molmil](/molmil-images/mine/6uww) | |
8DA4
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![BU of 8da4 by Molmil](/molmil-images/mine/8da4) | Coevolved affibody-Z domain pair LL1.c2 | 分子名称: | Affibody LL1.FIVM, Immunoglobulin G-binding protein A, SULFATE ION, ... | 著者 | Jude, K.M, Yang, A, Garcia, K.C. | 登録日 | 2022-06-13 | 公開日 | 2023-07-26 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions. Science, 381, 2023
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6UYG
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![BU of 6uyg by Molmil](/molmil-images/mine/6uyg) | Structure of Hepatitis C Virus Envelope Glycoprotein E2c3 core from genotype 6a bound to broadly neutralizing antibody AR3A and non neutralizing antibody E1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein E2, ... | 著者 | Tzarum, N, Wilson, I.A, Zhu, J. | 登録日 | 2019-11-13 | 公開日 | 2020-04-22 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.375 Å) | 主引用文献 | Proof of concept for rational design of hepatitis C virus E2 core nanoparticle vaccines. Sci Adv, 6, 2020
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8DA7
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7TF2
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![BU of 7tf2 by Molmil](/molmil-images/mine/7tf2) | Cryo-EM structure of SARS-CoV-2 Kappa (B.1.617.1) Q484I spike protein | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Zhu, X, Saville, J.W, Mannar, D, Srivastava, S.S, Berezuk, A.M, Demers, J.P, Zhou, S, Tuttle, K.S, Subramaniam, S. | 登録日 | 2022-01-06 | 公開日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (3.62 Å) | 主引用文献 | Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants. Nat Commun, 13, 2022
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7TF5
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![BU of 7tf5 by Molmil](/molmil-images/mine/7tf5) | Cryo-EM structure of SARS-CoV-2 Kappa (B.1.617.1) spike protein | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Zhu, X, Saville, J.W, Mannar, D, Srivastava, S.S, Berezuk, A.M, Demers, J.P, Zhou, S, Tuttle, K.S, Subramaniam, S. | 登録日 | 2022-01-06 | 公開日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | 主引用文献 | Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants. Nat Commun, 13, 2022
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6V5T
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![BU of 6v5t by Molmil](/molmil-images/mine/6v5t) | |
8G1M
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![BU of 8g1m by Molmil](/molmil-images/mine/8g1m) | |
8DSY
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![BU of 8dsy by Molmil](/molmil-images/mine/8dsy) | PPARg bound to inverse agonist H3B-343 | 分子名称: | Peroxisome proliferator-activated receptor gamma, {5-[(5-{[(4-tert-butylphenyl)methyl]carbamoyl}-2,3-dimethyl-1H-indol-1-yl)methyl]-2-chlorophenoxy}acetic acid | 著者 | Larsen, N.A. | 登録日 | 2022-07-24 | 公開日 | 2022-09-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPAR gamma by inverse agonists. J.Biol.Chem., 298, 2022
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8FPC
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![BU of 8fpc by Molmil](/molmil-images/mine/8fpc) | Conformation 1 of the ligand binding domain (LBDconf1) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100mM glutamate (Open-CaNaMg) | 分子名称: | CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamate receptor 2 | 著者 | Nakagawa, T. | 登録日 | 2023-01-04 | 公開日 | 2024-02-28 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.78 Å) | 主引用文献 | The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport. Nat.Struct.Mol.Biol., 31, 2024
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8FP4
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8FPH
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![BU of 8fph by Molmil](/molmil-images/mine/8fph) | Conformation 2 of the ligand binding domain (LBDconf2) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100mM glutamate (Open-CaNaMg) | 分子名称: | CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamate receptor 2 | 著者 | Nakagawa, T. | 登録日 | 2023-01-04 | 公開日 | 2024-02-28 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | 主引用文献 | The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport. Nat.Struct.Mol.Biol., 31, 2024
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8FQ5
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8FP9
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![BU of 8fp9 by Molmil](/molmil-images/mine/8fp9) | GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100mM glutamate (Open-CaNaMg) | 分子名称: | CALCIUM ION, CHLORIDE ION, Glutamate receptor 2, ... | 著者 | Nakagawa, T. | 登録日 | 2023-01-04 | 公開日 | 2024-02-28 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.44 Å) | 主引用文献 | The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport. Nat.Struct.Mol.Biol., 31, 2024
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8FQ8
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8FPL
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![BU of 8fpl by Molmil](/molmil-images/mine/8fpl) | LBD conformation 2 (LBDconf2) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100uM CNQX (Closed-CaNaMg) | 分子名称: | 6-(aminomethyl)-7-nitro-1,4-dihydroquinoxaline-2,3-dione, CYCLOTHIAZIDE, Glutamate receptor 2 | 著者 | Nakagawa, T. | 登録日 | 2023-01-04 | 公開日 | 2024-02-28 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.81 Å) | 主引用文献 | The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport. Nat.Struct.Mol.Biol., 31, 2024
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8FQE
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![BU of 8fqe by Molmil](/molmil-images/mine/8fqe) | |