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6VEL

Crystal Structure of Human E-cadherin bound by mouse monoclonal antibody 66E8Fab

Summary for 6VEL
Entry DOI10.2210/pdb6vel/pdb
Descriptor66E8 Fab Heavy Chain, 66E8 Fab Light Chain, Ubiquitin-like protein SMT3,Cadherin-1, ... (6 entities in total)
Functional Keywordsssgcid, cadherin, e-cadherin, antibody, structural genomics, seattle structural genomics center for infectious disease, cell adhesion, cell adhesion-immune system complex, cell adhesion/immune system
Biological sourceMus musculus
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Total number of polymer chains3
Total formula weight89540.77
Authors
Seattle Structural Genomics Center for Infectious Disease,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2020-01-02, release date: 2020-01-29, Last modification date: 2023-10-25)
Primary citationMaker, A.,Bolejack, M.,Schecterson, L.,Hammerson, B.,Abendroth, J.,Edwards, T.E.,Staker, B.,Myler, P.J.,Gumbiner, B.M.
Regulation of multiple dimeric states of E-cadherin by adhesion activating antibodies revealed through Cryo-EM and X-ray crystallography.
Pnas Nexus, 1:pgac163-pgac163, 2022
Cited by
PubMed: 36157596
DOI: 10.1093/pnasnexus/pgac163
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.65 Å)
Structure validation

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