6VEL

Crystal Structure of Human E-cadherin bound by mouse monoclonal antibody 66E8Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (H)	66E8 Fab Heavy Chain	polymer	243	26407.8	1		Mus musculus
2	B (L)	66E8 Fab Light Chain	polymer	233	25810.7	1		Mus musculus
3	C (C)	Ubiquitin-like protein SMT3,Cadherin-1	polymer	331	36625.7	1	UniProt (Q12306) UniProt (P12830) Pfam (PF00240) Pfam (PF00028)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	CAM 120/80,Epithelial cadherin,E-cadherin,Uvomorulin
4	D, E, F, G, J... (H, L, C)	SULFATE ION	non-polymer		96.1	6	Chemie (SO4)
5	H, I, L (C)	CALCIUM ION	non-polymer		40.1	3	Chemie (CA)
6	M, N, O (H, L, C)	water	water		18.0	128	Chemie (HOH)

Sequence modifications

C: 4 - 101 (UniProt: Q12306)

PDB	External Database	Details
Met -12	-	expression tag
Ala -11	-	expression tag
Ser -10	-	expression tag
Met -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Ser 0	-	expression tag
Met 1	-	expression tag
Ala 2	-	expression tag
Ser 3	-	expression tag

C: 102 - 318 (UniProt: P12830)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	88844.2
Non-Polymers*	Number of molecules	9
	Total formula weight	696.6
All*	Total formula weight	89540.8

*Water molecules are not included.