6VEL

Crystal Structure of Human E-cadherin bound by mouse monoclonal antibody 66E8Fab

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000794	cellular_component	condensed nuclear chromosome
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005886	cellular_component	plasma membrane
C	0005940	cellular_component	septin ring
C	0007155	biological_process	cell adhesion
C	0007156	biological_process	homophilic cell-cell adhesion
C	0016020	cellular_component	membrane
C	0016925	biological_process	protein sumoylation
C	0031386	molecular_function	protein tag activity
C	0042802	molecular_function	identical protein binding
C	0044389	molecular_function	ubiquitin-like protein ligase binding
C	0098609	biological_process	cell-cell adhesion

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue SO4 H 301

Chain	Residue
C	SO4404
H	GLY118
H	ASN119
H	TYR120
H	TYR121

---

site_id	AC2
Number of Residues	7
Details	binding site for residue SO4 H 302

Chain	Residue
H	TYR121
L	TYR51
L	HIS110
C	LYS206
C	SER303
C	THR304
H	TYR120

---

site_id	AC3
Number of Residues	6
Details	binding site for residue SO4 L 301

Chain	Residue
C	GLY301
L	GLU112
L	TYR113
L	HOH403
L	HOH407
L	HOH433

---

site_id	AC4
Number of Residues	5
Details	binding site for residue SO4 L 302

Chain	Residue
L	GLN56
L	LYS64
L	PHE81
L	GLU100
L	ASP101

---

site_id	AC5
Number of Residues	5
Details	binding site for residue CA C 401

Chain	Residue
C	GLU112
C	ASP168
C	GLU170
C	ASP204
C	HOH503

---

site_id	AC6
Number of Residues	6
Details	binding site for residue CA C 402

Chain	Residue
C	ASN203
C	ASN205
C	ASP235
C	ASP237
C	ASN244
C	ASP296

---

site_id	AC7
Number of Residues	7
Details	binding site for residue SO4 C 403

Chain	Residue
C	VAL104
C	VAL104
C	ILE105
C	ILE105
C	MET193
C	MET193
C	HOH511

---

site_id	AC8
Number of Residues	3
Details	binding site for residue SO4 C 404

Chain	Residue
C	THR305
H	GLY50
H	SO4301

---

site_id	AC9
Number of Residues	6
Details	binding site for residue CA C 405

Chain	Residue
C	GLU112
C	GLU170
C	ASP201
C	GLN202
C	ASP204
C	ASP237

---

Functional Information from PROSITE/UniProt

site_id	PS00232
Number of Residues	11
Details	CADHERIN_1 Cadherin domain signature. ItVtDqNDNkP

Chain	Residue	Details
C	ILE197-PRO207

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR211-HIS217

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Site: {"description":"Cleavage; by S.pyogenes SpeB","evidences":[{"source":"PubMed","id":"23532847","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Glycosylation: {"description":"O-linked (Man...) serine","evidences":[{"source":"UniProtKB","id":"P09803","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Glycosylation: {"description":"O-linked (Man...) threonine","evidences":[{"source":"UniProtKB","id":"P09803","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---