1H6F
| Human TBX3, a transcription factor responsible for ulnar-mammary syndrome, bound to a palindromic DNA site | 分子名称: | 5'-D(*TP*AP*AP*TP*TP*TP*CP*AP*CP*AP*CP*CP*TP* AP*GP*GP*TP*GP*TP*GP*AP*AP*AP*T)-3', MAGNESIUM ION, T-BOX TRANSCRIPTION FACTOR TBX3 | 著者 | Coll, M, Muller, C.W. | 登録日 | 2001-06-13 | 公開日 | 2002-04-19 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure of the DNA-Bound T-Box Domain of Human Tbx3, a Transcription Factor Responsible for Ulnar- Mammary Syndrome Structure, 10, 2002
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6IPU
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5CYI
| CDK2/Cyclin A covalent complex with 6-(cyclohexylmethoxy)-N-(4-(vinylsulfonyl)phenyl)-9H-purin-2-amine (NU6300) | 分子名称: | 6-(cyclohexylmethoxy)-N-[4-(ethylsulfonyl)phenyl]-9H-purin-2-amine, Cyclin-A2, Cyclin-dependent kinase 2 | 著者 | Anscombe, E, Meschini, E, Vidal, R.M, Martin, M.P, Staunton, D, Geitmann, M, Danielson, U.H, Stanley, W.A, Wang, L.Z, Reuillon, T, Golding, B.T, Cano, C, Newell, D.R, Noble, M.E.M, Wedge, S.R, Endicott, J.A, Griffin, R.J. | 登録日 | 2015-07-30 | 公開日 | 2015-09-16 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Identification and Characterization of an Irreversible Inhibitor of CDK2. Chem.Biol., 22, 2015
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6N7K
| Cryo-EM structure of tetrameric Ptch1 in complex with ShhNp (form II) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Yan, N, Gong, X, Qian, H.W. | 登録日 | 2018-11-27 | 公開日 | 2019-05-29 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (6.5 Å) | 主引用文献 | Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm. Nat Commun, 10, 2019
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2C6A
| Solution structure of the C4 zinc-finger domain of HDM2 | 分子名称: | UBIQUITIN-PROTEIN LIGASE E3 MDM2, ZINC ION | 著者 | Yu, G.W, Allen, M.D, Andreeva, A, Fersht, A.R, Bycroft, M. | 登録日 | 2005-11-08 | 公開日 | 2006-01-04 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution Structure of the C4 Zinc Finger Domain of Hdm2. Protein Sci., 15, 2006
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2C6B
| Solution structure of the C4 zinc-finger domain of HDM2 | 分子名称: | UBIQUITIN-PROTEIN LIGASE E3 MDM2, ZINC ION | 著者 | Yu, G.W, Allen, M.D, Andreeva, A, Fersht, A.R, Bycroft, M. | 登録日 | 2005-11-08 | 公開日 | 2006-01-04 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution Structure of the C4 Zinc Finger Domain of Hdm2. Protein Sci., 15, 2006
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2MEV
| STRUCTURAL REFINEMENT AND ANALYSIS OF MENGO VIRUS | 分子名称: | MENGO VIRUS COAT PROTEIN (SUBUNIT VP1), MENGO VIRUS COAT PROTEIN (SUBUNIT VP2), MENGO VIRUS COAT PROTEIN (SUBUNIT VP3), ... | 著者 | Rossmann, M.G. | 登録日 | 1989-04-21 | 公開日 | 1990-01-15 | 最終更新日 | 2023-04-19 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural refinement and analysis of Mengo virus. J.Mol.Biol., 211, 1990
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4MD9
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3WSO
| Crystal structure of the Skp1-FBG3 complex | 分子名称: | F-box only protein 44, S-phase kinase-associated protein 1 | 著者 | Kumanomidou, T, Nishio, K, Takagi, K, Nakagawa, T, Suzuki, A, Yamane, T, Tokunaga, F, Iwai, K, Murakami, A, Yoshida, Y, Tanaka, K, Mizushima, T. | 登録日 | 2014-03-18 | 公開日 | 2015-03-25 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | The Structural Differences between a Glycoprotein Specific F-Box Protein Fbs1 and Its Homologous Protein FBG3 Plos One, 10, 2015
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3O6Q
| The Structure of SpoIISA and SpoIISB, a Toxin - Antitoxin System | 分子名称: | Stage II sporulation protein SA, Stage II sporulation protein SB | 著者 | Levdikov, V.M, Blagova, E.V, Lebedev, A.A, Wilkinson, A.J, Florek, P, Barak, I. | 登録日 | 2010-07-29 | 公開日 | 2010-12-08 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The structure and interactions of SpoIISA and SpoIISB, a toxin-antitoxin system in Bacillus subtilis. J.Biol.Chem., 161, 2010
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1QAI
| CRYSTAL STRUCTURES OF THE N-TERMINAL FRAGMENT FROM MOLONEY MURINE LEUKEMIA VIRUS REVERSE TRANSCRIPTASE COMPLEXED WITH NUCLEIC ACID: FUNCTIONAL IMPLICATIONS FOR TEMPLATE-PRIMER BINDING TO THE FINGERS DOMAIN | 分子名称: | DNA (5'-D(*CP*AP*TP*GP*CP*AP*TP*G)-3'), MERCURY (II) ION, REVERSE TRANSCRIPTASE | 著者 | Najmudin, S, Cote, M, Sun, D, Yohannan, S, Montano, S.P, Gu, J, Georgiadis, M.M. | 登録日 | 1999-03-12 | 公開日 | 2000-03-20 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structures of an N-terminal fragment from Moloney murine leukemia virus reverse transcriptase complexed with nucleic acid: functional implications for template-primer binding to the fingers domain. J.Mol.Biol., 296, 2000
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3O7L
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3IIM
| The structure of hCINAP-dADP complex at 2.0 angstroms resolution | 分子名称: | (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 2'-DEOXYADENOSINE-5'-DIPHOSPHATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Zographos, S.E, Drakou, C.E, Leonidas, D.D. | 登録日 | 2009-08-02 | 公開日 | 2010-10-06 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: Structural and functional studies. Proteins, 80, 2012
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3IIJ
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6Z45
| CDK9-Cyclin-T1 complex bound by compound 24 | 分子名称: | (1~{S},3~{R})-3-acetamido-~{N}-[5-chloranyl-4-(5,5-dimethyl-4,6-dihydropyrrolo[1,2-b]pyrazol-3-yl)pyridin-2-yl]cyclohexane-1-carboxamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cyclin-T1, ... | 著者 | Ferguson, A, Collie, G.W. | 登録日 | 2020-05-22 | 公開日 | 2020-12-23 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (3.37 Å) | 主引用文献 | Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies. J.Med.Chem., 63, 2020
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3IIK
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3IIL
| The structure of hCINAP-MgADP-Pi complex at 2.0 angstroms resolution | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Coilin-interacting nuclear ATPase protein, LITHIUM ION, ... | 著者 | Zographos, S.E, Drakou, C.E, Leonidas, D.D. | 登録日 | 2009-08-02 | 公開日 | 2010-10-06 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: Structural and functional studies. Proteins, 80, 2012
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5LV4
| Crystal structure of mouse PRMT6 in complex with inhibitor LH1236 | 分子名称: | (2~{R})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[[4-azanyl-1-(methoxymethyl)-2-oxidanylidene-pyrimidin-5-yl]methyl]amino]-2-azanyl-butanoic acid, Protein arginine N-methyltransferase 6 | 著者 | Cura, V, Marechal, N, Troffer-Charlier, N, Halby, L, Arimondo, P, Bonnefond, L, Cavarelli, J. | 登録日 | 2016-09-12 | 公開日 | 2017-09-20 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors. Philos. Trans. R. Soc. Lond., B, Biol. Sci., 373, 2018
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1JWH
| Crystal Structure of Human Protein Kinase CK2 Holoenzyme | 分子名称: | Casein kinase II beta chain, Casein kinase II, alpha chain, ... | 著者 | Niefind, K, Guerra, B, Ermakowa, I, Issinger, O.G. | 登録日 | 2001-09-04 | 公開日 | 2002-03-04 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme. EMBO J., 20, 2001
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6UCM
| Transcription factor DeltaFosB bZIP domain self-assembly, type-II crystal | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, Protein fosB | 著者 | Yin, Z, Machius, M, Rudenko, G. | 登録日 | 2019-09-16 | 公開日 | 2020-01-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.424 Å) | 主引用文献 | Self-assembly of the bZIP transcription factor Delta FosB. Curr Res Struct Biol, 2, 2020
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2YB1
| Structure of an amidohydrolase from Chromobacterium violaceum (EFI target EFI-500202) with bound Mn, AMP and phosphate. | 分子名称: | ADENOSINE MONOPHOSPHATE, AMIDOHYDROLASE, MANGANESE (II) ION, ... | 著者 | Vetting, M.W, Hillerich, B, Foti, R, Seidel, R.D, Zencheck, W.D, Toro, R, Imker, H.J, Raushel, F.M, Gerlt, J.A, Almo, S.C. | 登録日 | 2011-02-25 | 公開日 | 2011-03-16 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.898 Å) | 主引用文献 | Prospecting for Unannotated Enzymes: Discovery of a 3',5'-Nucleotide Bisphosphate Phosphatase within the Amidohydrolase Superfamily. Biochemistry, 53, 2014
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3JVK
| Crystal structure of bromodomain 1 of mouse Brd4 in complex with histone H3-K(ac)14 | 分子名称: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, histone H3.3 peptide | 著者 | Vollmuth, F, Blankenfeldt, W, Geyer, M. | 登録日 | 2009-09-17 | 公開日 | 2009-10-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structures of the Dual Bromodomains of the P-TEFb-activating Protein Brd4 at Atomic Resolution J.Biol.Chem., 284, 2009
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1A02
| STRUCTURE OF THE DNA BINDING DOMAINS OF NFAT, FOS AND JUN BOUND TO DNA | 分子名称: | AP-1 FRAGMENT FOS, AP-1 FRAGMENT JUN, DNA (5'-D(*DAP*DAP*DCP*DTP*DAP*DTP*DGP*DAP*DAP*DAP*DCP*DAP*DAP*DAP*DTP*DTP*DTP*DTP*DCP*DC)-3'), ... | 著者 | Chen, L, Glover, J.N.M, Hogan, P.G, Rao, A, Harrison, S.C. | 登録日 | 1997-12-08 | 公開日 | 1998-05-27 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA. Nature, 392, 1998
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1A7M
| LEUKAEMIA INHIBITORY FACTOR CHIMERA (MH35-LIF), NMR, 20 STRUCTURES | 分子名称: | LEUKEMIA INHIBITORY FACTOR | 著者 | Hinds, M.G, Maurer, T, Zhang, J.-G, Nicola, N.A, Norton, R.S. | 登録日 | 1998-03-16 | 公開日 | 1999-04-20 | 最終更新日 | 2022-02-16 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of leukemia inhibitory factor. J.Biol.Chem., 273, 1998
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2QVS
| Crystal Structure of Type IIa Holoenzyme of cAMP-dependent Protein Kinase | 分子名称: | cAMP-dependent protein kinase type II-alpha regulatory subunit, cAMP-dependent protein kinase, alpha-catalytic subunit | 著者 | Wu, J, Brown, S.H.J, von Daake, S, Taylor, S.S. | 登録日 | 2007-08-08 | 公開日 | 2007-10-23 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | PKA type IIalpha holoenzyme reveals a combinatorial strategy for isoform diversity. Science, 318, 2007
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