PDB: 45459 件ウェブページステータス検索Chemie searchBIRD

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6O6Y	Crystal structure of Csm6 in complex with cyclic-tetraadenylates (cA4) by cocrystallization of Csm6 and cA4 分子名称: 2',3'- cyclic AMP, 3'-O-[(R)-{[(2S,3aS,4S,6S,6aS)-6-(6-amino-9H-purin-9-yl)-2-hydroxy-2-oxotetrahydro-2H-2lambda~5~-furo[3,4-d][1,3,2]dioxaphosphol-4-yl]methoxy}(hydroxy)phosphoryl]adenosine, Csm6 著者 Jia, N, Patel, D.J. 登録日 2019-03-07 公開日 2019-07-31 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA4Cleavage with ApA>p Formation Terminating RNase Activity. Mol.Cell, 75, 2019
5CW4	Structure of CfBRCC36-CfKIAA0157 complex (Selenium Edge) 分子名称: BRCA1/BRCA2-containing complex subunit 3, GLYCEROL, Protein FAM175B, ... 著者 Zeqiraj, E. 登録日 2015-07-27 公開日 2015-09-16 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (2.543 Å) 主引用文献 Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function. Mol.Cell, 59, 2015
6O8T	Syn-safencin 96 分子名称: Circular bacteriocin, circularin A/uberolysin family 著者 Fields, F.R, Lee, S.W. 登録日 2019-03-11 公開日 2020-04-15 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy. Acs Pharmacol Transl Sci, 3, 2020
6O6V	Crystal structure of Csm6 in complex with cA4 by soaking cA4 into Csm6 分子名称: Csm6, Cyclic RNA cA4 著者 Jia, N, Patel, D.J. 登録日 2019-03-07 公開日 2019-07-31 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA4Cleavage with ApA>p Formation Terminating RNase Activity. Mol.Cell, 75, 2019
8J1G	Structure of amino acid dehydrogenase in complex with NADPH 分子名称: 1,2-ETHANEDIOL, ARGININE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Sakuraba, H, Ohshima, T. 登録日 2023-04-12 公開日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 First crystal structure of an NADP + -dependent l-arginine dehydrogenase belonging to the mu-crystallin family. Int.J.Biol.Macromol., 249, 2023
5D9A	Influenza C Virus RNA-dependent RNA Polymerase - Space group P212121 分子名称: Polymerase acidic protein, Polymerase basic protein 2, RNA-directed RNA polymerase catalytic subunit 著者 Hengrung, N, El Omari, K, Serna Martin, I, Vreede, F.T, Cusack, S, Rambo, R.P, Vonrhein, C, Bricogne, G, Stuart, D.I, Grimes, J.M, Fodor, E. 登録日 2015-08-18 公開日 2015-10-21 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (4.3 Å) 主引用文献 Crystal structure of the RNA-dependent RNA polymerase from influenza C virus. Nature, 527, 2015
5DCS	R2-like ligand-binding oxidase with aerobically reconstituted Mn/Fe cofactor (long soak) 分子名称: FE (III) ION, MANGANESE (II) ION, MANGANESE (III) ION, ... 著者 Griese, J.J, Hogbom, M. 登録日 2015-08-24 公開日 2015-09-09 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.006 Å) 主引用文献 Structural Basis for Oxygen Activation at a Heterodinuclear Manganese/Iron Cofactor. J.Biol.Chem., 290, 2015
8JHO	Cryo-EM structure of the histone deacetylase complex Rpd3S in complex with di-nucleosome 分子名称: Chromatin modification-related protein EAF3, Di-nucleosome template foward, Di-nucleosome template reverse, ... 著者 Wang, H. 登録日 2023-05-25 公開日 2023-09-27 最終更新日 2023-12-27 実験手法 ELECTRON MICROSCOPY (7.6 Å) 主引用文献 Structure of histone deacetylase complex Rpd3S bound to nucleosome. Nat.Struct.Mol.Biol., 30, 2023
6O70	Crystal structure of Csm6 H132A mutant in complex with cA4 by cocrystallization of cA4 and Csm6 H132A mutant 分子名称: 2',3'- cyclic AMP, 3'-O-[(R)-{[(2S,3aS,4S,6S,6aS)-6-(6-amino-9H-purin-9-yl)-2-hydroxy-2-oxotetrahydro-2H-2lambda~5~-furo[3,4-d][1,3,2]dioxaphosphol-4-yl]methoxy}(hydroxy)phosphoryl]adenosine, Csm6 著者 Jia, N, Patel, D.J. 登録日 2019-03-07 公開日 2019-07-31 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA4Cleavage with ApA>p Formation Terminating RNase Activity. Mol.Cell, 75, 2019
5EHM	Crystal structure of the Drosophila CG3822 KaiR1D ligand binding domain complex with NMDA 分子名称: N-methyl-D-aspartic acid, RE06730p,CG3822 著者 Dharkar, P, Mayer, M.L. 登録日 2015-10-28 公開日 2016-11-09 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.281 Å) 主引用文献 Novel Functional Properties of Drosophila CNS Glutamate Receptors. Neuron, 92, 2016
6O8Q	HUaa 19bp SYM DNA pH 4.5 分子名称: DNA (57-MER), DNA-binding protein HU-alpha 著者 Remesh, S.G, Hammel, M. 登録日 2019-03-11 公開日 2020-03-18 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.216 Å) 主引用文献 Nucleoid remodeling during environmental adaptation is regulated by HU-dependent DNA bundling. Nat Commun, 11, 2020
6OVQ	Crystal structure of mithramycin 3-side chain keto-reductase MtmW 分子名称: GLYCEROL, Putative Side chain reductase 著者 Hou, C, Yu, X, Rohr, J, Tsodikov, O.V. 登録日 2019-05-08 公開日 2019-11-27 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Discovery of a Cryptic Intermediate in Late Steps of Mithramycin Biosynthesis. Angew.Chem.Int.Ed.Engl., 59, 2020
6OAC	PQR530 [(S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine] bound to the PI3Ka catalytic subunit p110alpha 分子名称: 4-(difluoromethyl)-5-{4-[(3S)-3-methylmorpholin-4-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}pyridin-2-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 著者 Burke, J.E, McPhail, J.A. 登録日 2019-03-15 公開日 2019-06-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 (S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase. J.Med.Chem., 62, 2019
5EQ4	Crystal structure of the SrpA adhesin R347E mutant from Streptococcus sanguinis 分子名称: ACETATE ION, CALCIUM ION, Platelet-binding glycoprotein 著者 Loukachevitch, L.V, McCulloch, K.M, Vann, K.R, Wawrzak, Z, Anderson, S, Iverson, T.M. 登録日 2015-11-12 公開日 2016-01-27 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural Basis for Sialoglycan Binding by the Streptococcus sanguinis SrpA Adhesin. J.Biol.Chem., 291, 2016
5DOQ	The structure of bd oxidase from Geobacillus thermodenitrificans 分子名称: Bd-type quinol oxidase subunit I, Bd-type quinol oxidase subunit II, CIS-HEME D HYDROXYCHLORIN GAMMA-SPIROLACTONE, ... 著者 Safarian, S, Mueller, H, Rajendran, C, Preu, J, Ovchinnikov, S, Kusumoto, T, Hirose, T, Langer, J, Sakamoto, J, Michel, H. 登録日 2015-09-11 公開日 2016-05-04 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 Structure of a bd oxidase indicates similar mechanisms for membrane-integrated oxygen reductases. Science, 352, 2016
8P6I	Crystal structure of the 139H2 Fab fragment bound to Muc1 peptide epitope 分子名称: 139H2 HC, 139H2 LC, Mucin-1 著者 Beugelink, J.W, Peng, W, Siborova, M, Pronker, M.F, Snijder, J, Janssen, B.J.C. 登録日 2023-05-26 公開日 2024-04-03 最終更新日 2024-04-10 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Reverse-engineering the anti-MUC1 antibody 139H2 by mass spectrometry-based de novo sequencing. Life Sci Alliance, 7, 2024
5DSX	Crystal structure of Dot1L in complex with inhibitor CPD10 [6'-chloro-1,4-dimethyl-5'-(2-methyl-6-((4-(methylamino)pyrimidin-2-yl)amino)-1H-indol-1-yl)-[3,3'-bipyridin]-2(1H)-one] 分子名称: 6'-chloro-1,4-dimethyl-5'-(2-methyl-6-{[4-(methylamino)pyrimidin-2-yl]amino}-1H-indol-1-yl)-3,3'-bipyridin-2(1H)-one, Histone-lysine N-methyltransferase, H3 lysine-79 specific, ... 著者 Scheufler, C, Gaul, C, Be, C, Moebitz, H. 登録日 2015-09-17 公開日 2016-06-15 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach. Acs Med.Chem.Lett., 7, 2016
5DUU	Crystal structure of the human galectin-4 N-terminal carbohydrate recognition domain in complex with glycerol 分子名称: GLYCEROL, Galectin-4 著者 Bum-Erdene, K, Blanchard, H. 登録日 2015-09-21 公開日 2016-02-17 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural characterisation of human galectin-4 N-terminal carbohydrate recognition domain in complex with glycerol, lactose, 3'-sulfo-lactose, and 2'-fucosyllactose. Sci Rep, 6, 2016
5E8I	Crystal structure of the DNA binding domain of human transcription factor FLI1 in complex with a 10-mer DNA ACCGGAAGTG 分子名称: CALCIUM ION, DNA (5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*G)-3'), DNA (5'-D(*CP*AP*CP*TP*TP*CP*CP*GP*GP*T)-3'), ... 著者 Hou, C, Tsodikov, O.V. 登録日 2015-10-14 公開日 2015-12-09 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.45 Å) 主引用文献 Structural Basis for Dimerization and DNA Binding of Transcription Factor FLI1. Biochemistry, 54, 2015
8ON5	Structure of the tail fibre from an extracellular contractile injection system from Photorhabdus bacteria 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, Adenoviral fiber protein, ... 著者 Godfrey, A.E, Diaz-Saez, L. 登録日 2023-03-31 公開日 2024-04-10 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of the tail fibre from an extracellular contractile injection system from Photorhabdus bacteria To Be Published
8P7G	Structural characterization of PHOX2B and its DNA interactions shed lights into the molecular basis of the + 7Ala variant pathogenicity in CCHS 分子名称: Paired mesoderm homeobox protein 2B 著者 Russo, L, Diana, D, Fattorusso, R. 登録日 2023-05-30 公開日 2024-05-15 最終更新日 2024-06-26 実験手法 SOLUTION NMR 主引用文献 Structural characterization of PHOX2B and its DNA interaction shed light on the molecular basis of the +7Ala variant pathogenicity in CCHS. Chem Sci, 15, 2024
5EI4	First domain of human bromodomain BRD4 in complex with inhibitor 8-(5-Amino-1H-[1,2,4]triazol-3-ylsulfanylmethyl)-3-(4-chlorobenzyl)-7-ethyl-3,7-dihydropurine-2,6-dione 分子名称: 1,2-ETHANEDIOL, 8-[(3-azanyl-1~{H}-1,2,4-triazol-5-yl)sulfanylmethyl]-3-[(4-chlorophenyl)methyl]-7-ethyl-purine-2,6-dione, Bromodomain-containing protein 4 著者 Raux, B, Rebuffet, E, Betzi, S, Morelli, X. 登録日 2015-10-29 公開日 2016-01-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.05 Å) 主引用文献 Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins. J.Med.Chem., 59, 2016
5EQ2	Crystal Structure of the SrpA Adhesin from Streptococcus sanguinis 分子名称: ACETATE ION, CALCIUM ION, Platelet-binding glycoprotein 著者 Loukachevitch, L.V, McCulloch, K.M, Vann, K.R, Wawrzak, Z, Anderson, S, Iverson, T.M. 登録日 2015-11-12 公開日 2016-01-27 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural Basis for Sialoglycan Binding by the Streptococcus sanguinis SrpA Adhesin. J.Biol.Chem., 291, 2016
8J3N	Solution NMR structure of purS subunit of phosphoribosylformylglycinamidine synthase enzyme from Staphylococcus aureus 分子名称: Phosphoribosylformylglycinamidine synthase subunit PurS 著者 Wahab, A, Ashraf, F, Choudhary, M.I. 登録日 2023-04-17 公開日 2023-05-17 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Solution NMR structure of purS subunit of phosphoribosylformylglycinamidine synthase enzyme from Staphylococcus aureus To Be Published
8P67	Crystal structure of Thermothelomyces thermophila (double mutant EE) in complex with aldotetrauronic acid 分子名称: 1,2-ETHANEDIOL, 4-O-methyl-alpha-D-glucopyranuronic acid-(1-2)-beta-D-xylopyranose-(1-4)-beta-D-xylopyranose-(1-4)-beta-D-xylopyranose, GH30 family xylanase, ... 著者 Dimarogona, M, Pentari, C, Kosinas, C, Topakas, E. 登録日 2023-05-25 公開日 2024-05-22 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.37 Å) 主引用文献 Structural and molecular insights into a bifunctional glycoside hydrolase 30 xylanase specific to glucuronoxylan. Biotechnol.Bioeng., 121, 2024

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