7YQ4
| human insulin receptor bound with A62 DNA aptamer and insulin - locally refined | 分子名称: | IR-A62 aptamer, Insulin A chain, Insulin, ... | 著者 | Kim, J, Yunn, N, Ryu, S, Cho, Y. | 登録日 | 2022-08-05 | 公開日 | 2022-11-09 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.95 Å) | 主引用文献 | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures. Nat Commun, 13, 2022
|
|
7YQ6
| human insulin receptor bound with A62 DNA aptamer | 分子名称: | IR-A62 aptamer, Isoform Short of Insulin receptor | 著者 | Kim, J, Yunn, N, Ryu, S, Cho, Y. | 登録日 | 2022-08-05 | 公開日 | 2022-11-09 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (4.18 Å) | 主引用文献 | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures. Nat Commun, 13, 2022
|
|
7YQ5
| human insulin receptor bound with A62 DNA aptamer and insulin | 分子名称: | IR-A62 aptamer, Insulin A chain, Insulin, ... | 著者 | Kim, J, Yunn, N, Ryu, S, Cho, Y. | 登録日 | 2022-08-05 | 公開日 | 2022-11-09 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (4.27 Å) | 主引用文献 | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures. Nat Commun, 13, 2022
|
|
7YPP
| Structural basis of a superoxide dismutase from a tardigrade, Ramazzottius varieornatus strain YOKOZUNA-1. | 分子名称: | CALCIUM ION, COPPER (II) ION, Superoxide dismutase [Cu-Zn], ... | 著者 | Sim, K.-S, Fukuda, Y, Inoue, T. | 登録日 | 2022-08-04 | 公開日 | 2023-07-26 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of a superoxide dismutase from a tardigrade: Ramazzottius varieornatus strain YOKOZUNA-1. Acta Crystallogr.,Sect.F, 79, 2023
|
|
7YPR
| Structural basis of a superoxide dismutase from a tardigrade, Ramazzottius varieornatus strain YOKOZUNA-1. | 分子名称: | COPPER (II) ION, POTASSIUM ION, Superoxide dismutase [Cu-Zn], ... | 著者 | Sim, K.-S, Fukuda, Y, Inoue, T. | 登録日 | 2022-08-04 | 公開日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.101 Å) | 主引用文献 | Structure of a superoxide dismutase from a tardigrade: Ramazzottius varieornatus strain YOKOZUNA-1. Acta Crystallogr.,Sect.F, 79, 2023
|
|
8AMZ
| Spinach 19S proteasome | 分子名称: | 26S proteasome non-ATPase regulatory subunit 1 homolog, 26S proteasome non-ATPase regulatory subunit 2 homolog, 26S proteasome regulatory subunit 7, ... | 著者 | Kandolf, S, Grishkovskaya, I, Meinhart, A, Haselbach, D. | 登録日 | 2022-08-04 | 公開日 | 2022-08-24 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Cryo-EM structure of the plant 26S proteasome Plant Communications, 3, 2022
|
|
8DYO
| Cryo-EM structure of Importin-4 bound to RanGTP | 分子名称: | GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Importin-4, ... | 著者 | Bernardes, N.E, Fung, H.Y.J, Li, Y, Chen, Z, Chook, Y.M. | 登録日 | 2022-08-04 | 公開日 | 2022-09-21 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (7.1 Å) | 主引用文献 | Structure of IMPORTIN-4 bound to the H3-H4-ASF1 histone-histone chaperone complex. Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
8AMR
| Coiled-coil domain of human TRIM3 | 分子名称: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, GLYCEROL, Tripartite motif-containing protein 3 | 著者 | Perez-Borrajero, C, Murciano, B, Hennig, J. | 登録日 | 2022-08-04 | 公開日 | 2023-11-15 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Structural and biophysical studies of TRIM2 and TRIM3 To Be Published
|
|
8DYC
| Human CYP3A4 bound to a substrate | 分子名称: | 2-butyl-6-(butylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione, Cytochrome P450 3A4, GLYCEROL, ... | 著者 | Sevrioukova, I.F. | 登録日 | 2022-08-04 | 公開日 | 2022-10-26 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal Structure of CYP3A4 Complexed with Fluorol Identifies the Substrate Access Channel as a High-Affinity Ligand Binding Site. Int J Mol Sci, 23, 2022
|
|
7YPJ
| Spiral pentamer of the substrate-free Lon protease with a S678A mutation | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Lon protease | 著者 | Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I. | 登録日 | 2022-08-03 | 公開日 | 2023-10-25 | 最終更新日 | 2023-11-29 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
|
|
7YPK
| Close-ring hexamer of the substrate-bound Lon protease with an S678A mutation | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Lon protease, alpha-S1-casein | 著者 | Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I. | 登録日 | 2022-08-03 | 公開日 | 2023-10-25 | 最終更新日 | 2023-11-29 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
|
|
7YPI
| Spiral hexamer of the substrate-free Lon protease with a Y224S mutation | 分子名称: | Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | 著者 | Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I. | 登録日 | 2022-08-03 | 公開日 | 2023-10-25 | 最終更新日 | 2023-11-29 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
|
|
7YPH
| Open-spiral pentamer of the substrate-free Lon protease with a Y224S mutation | 分子名称: | Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | 著者 | Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I. | 登録日 | 2022-08-03 | 公開日 | 2023-10-25 | 最終更新日 | 2023-11-29 | 実験手法 | ELECTRON MICROSCOPY (3.68 Å) | 主引用文献 | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
|
|
8AMO
| Crystal structure of M. tuberculosis CYP143 | 分子名称: | CHLORIDE ION, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Bukhdruker, S, Varaksa, T, Grudo, A, Marin, E, Kapranov, I, Shevtsov, M, Gilep, A, Strushkevich, N, Borshchevskiy, V. | 登録日 | 2022-08-03 | 公開日 | 2023-02-15 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structural insights into 3Fe-4S ferredoxins diversity in M. tuberculosis highlighted by a first redox complex with P450. Front Mol Biosci, 9, 2022
|
|
8AMQ
| Crystal structure of the complex CYP143-FdxE from M. tuberculosis | 分子名称: | FE3-S4 CLUSTER, NICKEL (II) ION, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Bukhdruker, S, Varaksa, T, Smolskaya, S, Marin, E, Kapranov, I, Kovalev, K, Gilep, A, Strushkevich, N, Borshchevskiy, V. | 登録日 | 2022-08-03 | 公開日 | 2023-02-15 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural insights into 3Fe-4S ferredoxins diversity in M. tuberculosis highlighted by a first redox complex with P450. Front Mol Biosci, 9, 2022
|
|
8AMC
| Crystal Structure of cat allergen Fel d 4 | 分子名称: | Allergen Fel d 4, SULFATE ION | 著者 | Schooltink, L, Sagmeister, T, Gottstein, N, Pavkov-Keller, T, Keller, W. | 登録日 | 2022-08-03 | 公開日 | 2023-08-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Crystal Structure of cat allergen Fel d 4 To Be Published
|
|
8DYB
| |
8AM0
| Crystal structure of human T1061E PI3Kalpha in complex with its regulatory subunit and the inhibitor GDC-0077 (Inavolisib) | 分子名称: | (2R)-2-[[2-[(4S)-4-[bis(fluoranyl)methyl]-2-oxidanylidene-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanamide, 1,2-ETHANEDIOL, CHLORIDE ION, ... | 著者 | Goncalves, M, Johnson, J.L, Roewer, K.M. | 登録日 | 2022-08-02 | 公開日 | 2023-12-13 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (2.818 Å) | 主引用文献 | Epinephrine inhibits PI3K alpha via the Hippo kinases. Cell Rep, 42, 2023
|
|
8DXB
| HIV-1 reverse transcriptase/rilpivirine with bound fragment 5-fluoroindole-2-carboxylic acid at the NNRTI Adjacent site | 分子名称: | 1,2-ETHANEDIOL, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, 5-fluoroindole-2-carboxylic acid, ... | 著者 | Chopra, A, Ruiz, F.X, Bauman, J.D, Arnold, E. | 登録日 | 2022-08-02 | 公開日 | 2023-05-31 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Halo Library, a Tool for Rapid Identification of Ligand Binding Sites on Proteins Using Crystallographic Fragment Screening. J.Med.Chem., 66, 2023
|
|
8DXH
| HIV-1 reverse transcriptase/rilpivirine with bound fragment 5-fluoroquinazolin-4-ol at W266 site | 分子名称: | 1,2-ETHANEDIOL, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, 5-fluoranyl-3,4-dihydroquinazolin-4-ol, ... | 著者 | Chopra, A, Ruiz, F.X, Bauman, J.D, Arnold, E. | 登録日 | 2022-08-02 | 公開日 | 2023-05-31 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Halo Library, a Tool for Rapid Identification of Ligand Binding Sites on Proteins Using Crystallographic Fragment Screening. J.Med.Chem., 66, 2023
|
|
8DX8
| HIV-1 reverse transcriptase/rilpivirine with bound fragment 2-chloro-6-fluorophenethylamine at the 415 site | 分子名称: | 1,2-ETHANEDIOL, 2-(2-chloro-6-fluorophenyl)ethan-1-amine, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ... | 著者 | Chopra, A, Ruiz, F.X, Bauman, J.D, Arnold, E. | 登録日 | 2022-08-02 | 公開日 | 2023-05-31 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Halo Library, a Tool for Rapid Identification of Ligand Binding Sites on Proteins Using Crystallographic Fragment Screening. J.Med.Chem., 66, 2023
|
|
8DXM
| HIV-1 reverse transcriptase/rilpivirine with bound fragment 4-bromophenol at the Knuckles site | 分子名称: | 1,2-ETHANEDIOL, 4-BROMOPHENOL, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ... | 著者 | Chopra, A, Ruiz, F.X, Bauman, J.D, Arnold, E. | 登録日 | 2022-08-02 | 公開日 | 2023-05-31 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Halo Library, a Tool for Rapid Identification of Ligand Binding Sites on Proteins Using Crystallographic Fragment Screening. J.Med.Chem., 66, 2023
|
|
8DXI
| HIV-1 reverse transcriptase/rilpivirine with bound fragment [1-(4-fluorophenyl)-5-methyl-1H-pyrazol-4-yl]methanol at multiple sites | 分子名称: | 1,2-ETHANEDIOL, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, DIMETHYL SULFOXIDE, ... | 著者 | Chopra, A, Ruiz, F.X, Bauman, J.D, Arnold, E. | 登録日 | 2022-08-02 | 公開日 | 2023-05-31 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Halo Library, a Tool for Rapid Identification of Ligand Binding Sites on Proteins Using Crystallographic Fragment Screening. J.Med.Chem., 66, 2023
|
|
8DXK
| HIV-1 reverse transcriptase/rilpivirine with bound fragment 4-bromopyrazole at multiple sites | 分子名称: | 1,2-ETHANEDIOL, 4-bromo-1H-pyrazole, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ... | 著者 | Chopra, A, Ruiz, F.X, Bauman, J.D, Arnold, E. | 登録日 | 2022-08-02 | 公開日 | 2023-05-31 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Halo Library, a Tool for Rapid Identification of Ligand Binding Sites on Proteins Using Crystallographic Fragment Screening. J.Med.Chem., 66, 2023
|
|
8DXG
| HIV-1 reverse transcriptase/rilpivirine with bound fragment 5-(trifluoromethyl)pyridin-2-ol at W24 site | 分子名称: | 1,2-ETHANEDIOL, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, 5-(trifluoromethyl)pyridin-2-one, ... | 著者 | Chopra, A, Ruiz, F.X, Bauman, J.D, Arnold, E. | 登録日 | 2022-08-02 | 公開日 | 2023-05-31 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Halo Library, a Tool for Rapid Identification of Ligand Binding Sites on Proteins Using Crystallographic Fragment Screening. J.Med.Chem., 66, 2023
|
|