PDB: 45459 件ウェブページステータス検索Chemie searchBIRD

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8ZM2	Structure of human pyruvate dehydrogenase kinase 2 complexed with compound 16 分子名称: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial, methyl (9~{R})-9-oxidanyl-9-(trifluoromethyl)fluorene-4-carboxylate 著者 Akai, S, Orita, T, Nomura, A, Adachi, T. 登録日 2024-05-22 公開日 2024-06-19 最終更新日 2024-07-03 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Design and synthesis of novel fluorene derivatives as inhibitors of pyruvate dehydrogenase kinase. Bioorg.Med.Chem.Lett., 109, 2024
8CCV	E. coli NfsB mutant T41LN71S with nicotinate 分子名称: FLAVIN MONONUCLEOTIDE, NICOTINIC ACID, Oxygen-insensitive NAD(P)H nitroreductase 著者 Day, M.A, White, S.A, Hyde, E.I, Searle, P.F. 登録日 2023-01-27 公開日 2023-04-19 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure and Dynamics of Three Escherichia coli NfsB Nitro-Reductase Mutants Selected for Enhanced Activity with the Cancer Prodrug CB1954. Int J Mol Sci, 24, 2023
8CJ0	E. coli NfsB-T41Q/N71S/F124T/M127V mutant bound to nicotinate 分子名称: 1,2-ETHANEDIOL, FLAVIN MONONUCLEOTIDE, NICOTINIC ACID, ... 著者 White, S.A, Hyde, E.I, Day, M.A. 登録日 2023-02-11 公開日 2023-04-19 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Structure and Dynamics of Three Escherichia coli NfsB Nitro-Reductase Mutants Selected for Enhanced Activity with the Cancer Prodrug CB1954. Int J Mol Sci, 24, 2023
8C78	Crystal structure of human BCL6 BTB domain in complex with compound CCT374705 分子名称: (2~{S})-10-[(3-chloranyl-2-fluoranyl-pyridin-4-yl)amino]-2-cyclopropyl-3,3-bis(fluoranyl)-7-methyl-2,4-dihydro-1~{H}-[1,4]oxazepino[2,3-c]quinolin-6-one, 1,2-ETHANEDIOL, B-cell lymphoma 6 protein, ... 著者 Le Bihan, Y.-V, van Montfort, R.L.M. 登録日 2023-01-13 公開日 2023-04-26 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones. J.Med.Chem., 66, 2023
7S7V	Crystal structure of iNicSnFR3a Fluorescent Nicotine Sensor 分子名称: iNicSnFR 3.0 Fluorescent Nicotine Sensor 著者 Fan, C, Shivange, A.V, Looger, L.L, Lester, H.A, Rees, D.C. 登録日 2021-09-17 公開日 2021-10-13 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Correction: Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands. Elife, 11, 2022
7RZM	Crystal Structure of dnaN DNA polymerase III beta subunit from Stenotrophomonas maltophilia K279a 分子名称: DNA polymerase III subunit beta 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2021-08-27 公開日 2021-10-20 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Crystal Structure of dnaN DNA polymerase III beta subunit from Stenotrophomonas maltophilia K279a To Be Published
8C4J	CdaA-compound 4 complex 分子名称: 5-methylpyrimidin-4-amine, CHLORIDE ION, Diadenylate cyclase 著者 Neumann, P, Ficner, R. 登録日 2023-01-04 公開日 2023-06-07 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Computer-aided design of a cyclic di-AMP synthesizing enzyme CdaA inhibitor. Microlife, 4, 2023
8C4Q	CdaA-Apo 分子名称: CHLORIDE ION, Diadenylate cyclase 著者 Neumann, P, Ficner, R. 登録日 2023-01-04 公開日 2023-06-07 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Computer-aided design of a cyclic di-AMP synthesizing enzyme CdaA inhibitor. Microlife, 4, 2023
8C4O	CdaA-ATP complex 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, Diadenylate cyclase, ... 著者 Neumann, P, Ficner, R. 登録日 2023-01-04 公開日 2023-06-07 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Computer-aided design of a cyclic di-AMP synthesizing enzyme CdaA inhibitor. Microlife, 4, 2023
8C4R	CdaA-adenine complex 分子名称: ADENINE, CHLORIDE ION, Diadenylate cyclase 著者 Neumann, P, Ficner, R. 登録日 2023-01-04 公開日 2023-06-07 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Computer-aided design of a cyclic di-AMP synthesizing enzyme CdaA inhibitor. Microlife, 4, 2023
8C4M	CdaA-Adenosine complex 分子名称: ADENOSINE, CHLORIDE ION, Diadenylate cyclase 著者 Neumann, P, Ficner, R. 登録日 2023-01-04 公開日 2023-06-07 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.51 Å) 主引用文献 Computer-aided design of a cyclic di-AMP synthesizing enzyme CdaA inhibitor. Microlife, 4, 2023
8C4P	CdaA-compound 7 complex 分子名称: CHLORIDE ION, Diadenylate cyclase, ~{N}-[5-(2-azanyl-1,3-thiazol-4-yl)-4-methyl-1,3-thiazol-2-yl]ethanamide 著者 Neumann, P, Ficner, R. 登録日 2023-01-04 公開日 2023-06-07 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Computer-aided design of a cyclic di-AMP synthesizing enzyme CdaA inhibitor. Microlife, 4, 2023
8C0J	Structure of AmiB enzymatic domain bound to the EnvC LytM domain 分子名称: Murein hydrolase activator EnvC, N-acetylmuramoyl-L-alanine amidase, PHOSPHATE ION, ... 著者 Crow, A. 登録日 2022-12-17 公開日 2023-06-14 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (3.381 Å) 主引用文献 Activator-induced conformational changes regulate division-associated peptidoglycan amidases. Proc.Natl.Acad.Sci.USA, 120, 2023
8C3M	Crystal structure of ferredoxin/flavodoxin NADP+ oxidoreductase 1 (FNR1) V329H mutant from Bacillus cereus 分子名称: ACETATE ION, FLAVIN-ADENINE DINUCLEOTIDE, Ferredoxin--NADP reductase, ... 著者 Dahlen, S.A.B, Hammerstad, M, Hersleth, H.-P. 登録日 2022-12-26 公開日 2023-07-12 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Functional Diversity of Homologous Oxidoreductases-Tuning of Substrate Specificity by a FAD-Stacking Residue for Iron Acquisition and Flavodoxin Reduction. Antioxidants, 12, 2023
7SK0	TWIK1 in MSP1D1 lipid nanodisc at pH 7.4 分子名称: N-OCTANE, POTASSIUM ION, Potassium channel subfamily K member 1 著者 Turney, T.S, Brohawn, S.G. 登録日 2021-10-19 公開日 2021-11-24 最終更新日 2022-06-22 実験手法 ELECTRON MICROSCOPY (3.33 Å) 主引用文献 Structural Basis for pH-gating of the K + channel TWIK1 at the selectivity filter. Nat Commun, 13, 2022
7SK1	TWIK1 in MSP1E3D1 Lipid Nanodisc at pH 5.5 分子名称: N-OCTANE, POTASSIUM ION, Potassium channel subfamily K member 1, ... 著者 Turney, T.S, Brohawn, S.G. 登録日 2021-10-19 公開日 2021-11-24 最終更新日 2022-06-22 実験手法 ELECTRON MICROSCOPY (3.43 Å) 主引用文献 Structural Basis for pH-gating of the K + channel TWIK1 at the selectivity filter. Nat Commun, 13, 2022
7SC2	CRYSTAL STRUCTURE OF THE N-DOMAIN OF CARDIAC MUSCLE TROPONIN C TETHERED TO THE SWITCH REGION OF CARDIAC MUSCLE TROPONIN I (TETRAGONAL FORM) 分子名称: CALCIUM ION, Troponin C, slow skeletal and cardiac muscles,Troponin I, ... 著者 Sack, J.S. 登録日 2021-09-27 公開日 2021-12-01 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.814 Å) 主引用文献 X-ray structure of a human cardiac muscle troponin C/troponin I chimera in two crystal forms. Acta Crystallogr.,Sect.F, 78, 2022
8C9W	Crystal structure of the adenosine A2A receptor (construct A2A-PSB2-bRIL) complexed with Etrumadenant at the orthosteric pocket 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[2-azanyl-6-[1-[[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]methyl]-1,2,3-triazol-4-yl]pyrimidin-4-yl]-2-methyl-benzenecarbonitrile, ... 著者 Strater, N, Claff, T, Schlegel, J.G, Voss, J.H, Vaassen, V, Muller, C.E. 登録日 2023-01-23 公開日 2023-07-12 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.114 Å) 主引用文献 Crystal structure of adenosine A 2A receptor in complex with clinical candidate Etrumadenant reveals unprecedented antagonist interaction. Commun Chem, 6, 2023
8CP2	Structure of Aspartate-N-hydroxylase (FzmM)from Streptomyces sp. V2: complex with NADPH and L-aspartate 分子名称: 3-NITROPROPANOIC ACID, ASPARTIC ACID, DI(HYDROXYETHYL)ETHER, ... 著者 Rotilio, L, Mattevi, A. 登録日 2023-03-01 公開日 2023-07-12 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 A biosynthetic aspartate N-hydroxylase performs successive oxidations by holding intermediates at a site away from the catalytic center. J.Biol.Chem., 299, 2023
8C4A	Structural and interactional insights into the glideosome-associated connector from Toxoplasma gondii 分子名称: Putative anonymous antigen-1 著者 Kumar, A, Morgan, R.M.L, Matthews, S.J. 登録日 2023-01-03 公開日 2023-07-19 実験手法 X-RAY DIFFRACTION (2.675 Å) 主引用文献 Structural and regulatory insights into the glideosome-associated connector from Toxoplasma gondii. Elife, 12, 2023
7S0I	CRYSTAL STRUCTURE OF N1 NEURAMINIDASE FROM A/Michigan/45/2015(H1N1) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neuraminidase, ... 著者 Zhu, X, Wilson, I.A. 登録日 2021-08-30 公開日 2021-12-08 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.892 Å) 主引用文献 A Novel Recombinant Influenza Virus Neuraminidase Vaccine Candidate Stabilized by a Measles Virus Phosphoprotein Tetramerization Domain Provides Robust Protection from Virus Challenge in the Mouse Model. Mbio, 12, 2021
7SC3	CRYSTAL STRUCTURE OF THE N-DOMAIN OF CARDIAC MUSCLE TROPONIN C TETHERED TO THE SWITCH REGION OF CARDIAC MUSCLE TROPONIN I (ORTHORHOMBIC FORM) 分子名称: CALCIUM ION, Troponin C, slow skeletal and cardiac muscles,Troponin I, ... 著者 Sack, J.S. 登録日 2021-09-27 公開日 2021-12-01 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.229 Å) 主引用文献 X-ray structure of a human cardiac muscle troponin C/troponin I chimera in two crystal forms. Acta Crystallogr.,Sect.F, 78, 2022
7SL9	CryoEM structure of SMCT1 分子名称: Sodium-coupled monocarboxylate transporter 1, butanoic acid, nanobody Nb2 著者 Qu, Q, Han, L, Panova, O, Feng, L, Skiniotis, G. 登録日 2021-10-23 公開日 2021-12-15 最終更新日 2022-01-26 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structure and mechanism of the SGLT family of glucose transporters. Nature, 601, 2022
7RTG	Crystal Structure of the Human Adenosine Deaminase 1 分子名称: Adenosine deaminase, ZINC ION 著者 Ma, M.T, Lieberman, R.L, Blazeck, J, Jennings, M.R. 登録日 2021-08-13 公開日 2022-01-12 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.591 Å) 主引用文献 Catalytically active holo Homo sapiens adenosine deaminase I adopts a closed conformation. Acta Crystallogr D Struct Biol, 78, 2022
1QTR	CRYSTAL STRUCTURE ANALYSIS OF THE PROLYL AMINOPEPTIDASE FROM SERRATIA MARCESCENS 分子名称: PROLYL AMINOPEPTIDASE 著者 Yoshimoto, T, Kabashima, T, Uchikawa, K, Inoue, T, Tanaka, N. 登録日 1999-06-28 公開日 1999-07-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.32 Å) 主引用文献 Crystal structure of prolyl aminopeptidase from Serratia marcescens. J.Biochem.(Tokyo), 126, 1999

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