7SC2
CRYSTAL STRUCTURE OF THE N-DOMAIN OF CARDIAC MUSCLE TROPONIN C TETHERED TO THE SWITCH REGION OF CARDIAC MUSCLE TROPONIN I (TETRAGONAL FORM)
Summary for 7SC2
| Entry DOI | 10.2210/pdb7sc2/pdb |
| Descriptor | Troponin C, slow skeletal and cardiac muscles,Troponin I, cardiac muscle chimera, CALCIUM ION (3 entities in total) |
| Functional Keywords | calcium sensitizer, contraction regulation, contractile protein, cardiac troponin, muscle regulation, calcium-binding, ef-hand |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 1 |
| Total formula weight | 13340.27 |
| Authors | Sack, J.S. (deposition date: 2021-09-27, release date: 2021-12-01, Last modification date: 2024-05-22) |
| Primary citation | Yan, C.,Sack, J.S. X-ray structure of a human cardiac muscle troponin C/troponin I chimera in two crystal forms. Acta Crystallogr.,Sect.F, 78:17-24, 2022 Cited by PubMed Abstract: The X-ray crystal structure of a human cardiac muscle troponin C/troponin I chimera has been determined in two different crystal forms and shows a conformation of the complex that differs from that previously observed by NMR. The chimera consists of the N-terminal domain of troponin C (cTnC; residues 1-80) fused to the switch region of troponin I (cTnI; residues 138-162). In both crystal forms, the cTnI residues form a six-turn α-helix that lays across the hydrophobic groove of an adjacent cTnC molecule in the crystal structure. In contrast to previous models, the cTnI helix runs in a parallel direction relative to the cTnC groove and completely blocks the calcium desensitizer binding site of the cTnC-cTnI interface. PubMed: 34981771DOI: 10.1107/S2053230X21012395 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.814 Å) |
Structure validation
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