8QXT
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![BU of 8qxt by Molmil](/molmil-images/mine/8qxt) | CryoEM structure of a GroEL14-GroES7 complex in presence of ADP-BeFx with narrow GroEL7 trans ring conformation | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Chaperonin GroEL, ... | 著者 | Wagner, J, Caravajal, A.I, Beck, F, Bracher, A, Wan, W, Bohn, S, Koerner, R, Baumeister, W, Fernandez-Busnadiego, R, Hartl, F.U. | 登録日 | 2023-10-25 | 公開日 | 2024-07-03 | 最終更新日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Visualizing chaperonin function in situ by cryo-electron tomography Nature, 2024
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8EJ1
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6D5B
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![BU of 6d5b by Molmil](/molmil-images/mine/6d5b) | |
7NGP
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![BU of 7ngp by Molmil](/molmil-images/mine/7ngp) | D1-state of wild type human mitochondrial LONP1 protease | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial | 著者 | Mohammed, I, Schmitz, K.A, Schenck, N, Maier, T, Abrahams, J.P. | 登録日 | 2021-02-09 | 公開日 | 2021-04-28 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (15 Å) | 主引用文献 | Catalytic cycling of human mitochondrial Lon protease. Structure, 30, 2022
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7NGL
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![BU of 7ngl by Molmil](/molmil-images/mine/7ngl) | R-state of wild type human mitochondrial LONP1 protease bound to endogenous ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial | 著者 | Mohammed, I, Schmitz, K.A, Schenck, N, Maier, T, Abrahams, J.P. | 登録日 | 2021-02-09 | 公開日 | 2021-04-28 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Catalytic cycling of human mitochondrial Lon protease. Structure, 30, 2022
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4K90
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![BU of 4k90 by Molmil](/molmil-images/mine/4k90) | Extracellular metalloproteinase from Aspergillus | 分子名称: | BORIC ACID, CALCIUM ION, Extracellular metalloproteinase mep, ... | 著者 | Fernandez, D, Russi, S, Vendrell, J, Monod, M, Pallares, I. | 登録日 | 2013-04-19 | 公開日 | 2013-10-23 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | A functional and structural study of the major metalloprotease secreted by the pathogenic fungus Aspergillus fumigatus. Acta Crystallogr.,Sect.D, 69, 2013
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8EIG
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![BU of 8eig by Molmil](/molmil-images/mine/8eig) | The complex of phosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) with elexacaftor (VX-445) and ATP/Mg | 分子名称: | (6P)-N-(1,3-dimethyl-1H-pyrazole-4-sulfonyl)-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, ... | 著者 | Fiedorczuk, K, Chen, J. | 登録日 | 2022-09-15 | 公開日 | 2022-10-19 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Molecular structures reveal synergistic rescue of Delta 508 CFTR by Trikafta modulators. Science, 378, 2022
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6D7F
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![BU of 6d7f by Molmil](/molmil-images/mine/6d7f) | Bacteroides uniformis beta-glucuronidase 1 bound to thiophenyl-beta-D-glucuronide | 分子名称: | Beta-galactosidase/beta-glucuronidase, CHLORIDE ION, GLYCEROL, ... | 著者 | Walton, W.G, Pellock, S.J, Redinbo, M.R. | 登録日 | 2018-04-24 | 公開日 | 2018-10-17 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Three structurally and functionally distinct beta-glucuronidases from the human gut microbeBacteroides uniformis. J. Biol. Chem., 293, 2018
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8EIO
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![BU of 8eio by Molmil](/molmil-images/mine/8eio) | The complex of phosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) with elexacaftor (VX-445), lumacaftor (VX-809) and ATP/Mg | 分子名称: | (6P)-N-(1,3-dimethyl-1H-pyrazole-4-sulfonyl)-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, ... | 著者 | Fiedorczuk, K, Chen, J. | 登録日 | 2022-09-15 | 公開日 | 2022-10-19 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Molecular structures reveal synergistic rescue of Delta 508 CFTR by Trikafta modulators. Science, 378, 2022
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8EIQ
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![BU of 8eiq by Molmil](/molmil-images/mine/8eiq) | The complex of phosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) with Trikafta [elexacaftor (VX-445), tezacaftor (VX-661), ivacaftor (VX-770)] and ATP/Mg | 分子名称: | (6P)-N-(1,3-dimethyl-1H-pyrazole-4-sulfonyl)-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, ... | 著者 | Fiedorczuk, K, Chen, J. | 登録日 | 2022-09-15 | 公開日 | 2022-10-19 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Molecular structures reveal synergistic rescue of Delta 508 CFTR by Trikafta modulators. Science, 378, 2022
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6D9A
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8EW3
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![BU of 8ew3 by Molmil](/molmil-images/mine/8ew3) | Cryo EM structure of Vibrio cholerae NQR | 分子名称: | FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, Na(+)-translocating NADH-quinone reductase subunit A, ... | 著者 | Fuller, J.R, Juarez, O. | 登録日 | 2022-10-21 | 公開日 | 2022-11-16 | 実験手法 | ELECTRON MICROSCOPY (2.65159 Å) | 主引用文献 | Novel cofactor binding motifs, electron transfer and ion pumping mechanisms of the respiratory complex NQR To Be Published
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8EP1
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8EH2
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8EOW
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![BU of 8eow by Molmil](/molmil-images/mine/8eow) | |
6D5D
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![BU of 6d5d by Molmil](/molmil-images/mine/6d5d) | |
4KA2
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8EZ0
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![BU of 8ez0 by Molmil](/molmil-images/mine/8ez0) | Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S; denoted as IR-3CS) Symmetric conformation | 分子名称: | Insulin, Insulin receptor | 著者 | Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. | 登録日 | 2022-10-29 | 公開日 | 2022-11-09 | 最終更新日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor. Elife, 11, 2022
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4KDL
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![BU of 4kdl by Molmil](/molmil-images/mine/4kdl) | Crystal structure of p97/VCP N in complex with OTU1 UBXL | 分子名称: | Transitional endoplasmic reticulum ATPase, Ubiquitin thioesterase OTU1 | 著者 | Kim, S.J, Kim, E.E. | 登録日 | 2013-04-25 | 公開日 | 2014-03-19 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Structural Basis for Ovarian Tumor Domain-containing Protein 1 (OTU1) Binding to p97/Valosin-containing Protein (VCP). J.Biol.Chem., 289, 2014
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6DAX
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![BU of 6dax by Molmil](/molmil-images/mine/6dax) | X-ray crystal structure of VioC bound to Fe(II), L-homoarginine, and 2-oxoglutarate | 分子名称: | 2-OXOGLUTARIC ACID, Alpha-ketoglutarate-dependent L-arginine hydroxylase, FE (II) ION, ... | 著者 | Dunham, N.P, Mitchell, A.J, Boal, A.K. | 登録日 | 2018-05-02 | 公開日 | 2018-05-16 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Two Distinct Mechanisms for C-C Desaturation by Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenases: Importance of alpha-Heteroatom Assistance. J. Am. Chem. Soc., 140, 2018
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7NDH
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![BU of 7ndh by Molmil](/molmil-images/mine/7ndh) | Crystal structure of ZC3H12C PIN domain | 分子名称: | 1,2-ETHANEDIOL, Probable ribonuclease ZC3H12C, SODIUM ION | 著者 | Garg, A, Heinemann, U. | 登録日 | 2021-02-01 | 公開日 | 2021-05-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | PIN and CCCH Zn-finger domains coordinate RNA targeting in ZC3H12 family endoribonucleases. Nucleic Acids Res., 49, 2021
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7NDI
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6DC5
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7NDK
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8EYX
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![BU of 8eyx by Molmil](/molmil-images/mine/8eyx) | Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S; denoted as IR-3CS) Asymmetric conformation 1 | 分子名称: | Insulin, Insulin receptor | 著者 | Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. | 登録日 | 2022-10-29 | 公開日 | 2022-11-09 | 最終更新日 | 2022-12-07 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor. Elife, 11, 2022
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