PDB: 82554 件ウェブページステータス検索Chemie searchBIRD

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7S3F	Structure of cofactor pyridoxal 5-phosphate bound human ornithine decarboxylase in complex with its inhibitor 1-amino-oxy-3-aminopropane 分子名称: 3-AMINOOXY-1-AMINOPROPANE, Ornithine decarboxylase, PYRIDOXAL-5'-PHOSPHATE 著者 Zhou, X.E, Suino-Powell, K, Schultz, C.R, Aleiwi, B, Brunzelle, J.S, Lamp, J, Vega, I.E, Ellsworth, E, Bachmann, A.S, Melcher, K. 登録日 2021-09-06 公開日 2021-12-15 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 Structural basis of binding and inhibition of ornithine decarboxylase by 1-amino-oxy-3-aminopropane. Biochem.J., 478, 2021
8Q0P	Crystal Structure of an N-terminal Domain of Variant Surface Glycoprotein 21 (VSG21) of Trypanosome brucei brucei Lister 427 分子名称: Variant surface glycoprotein MITat 1.21 著者 Zeelen, J.P, Stebbins, C.E. 登録日 2023-07-28 公開日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 A structural classification of the variant surface glycoproteins of the African trypanosomey. Plos Negl Trop Dis, 17, 2023
8Q0E	Crystal Structure of the N-terminal Domain of Variant Surface Glycoprotein 545 (VSG545) of Trypanosome brucei brucei Lister 427 分子名称: Variant surface glycoprotein 545 著者 van Straaten, M, Stebbins, C.E. 登録日 2023-07-28 公開日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 A structural classification of the variant surface glycoproteins of the African trypanosomey. Plos Negl Trop Dis, 17, 2023
6OEL	Engineered Fab bound to IL-4 receptor 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, Interleukin-4 receptor subunit alpha, ... 著者 Jude, K.M, Moraga, I, Spangler, J.B, Garcia, K.C. 登録日 2019-03-27 公開日 2019-08-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 A strategy for the selection of monovalent antibodies that span protein dimer interfaces. J.Biol.Chem., 294, 2019
3NBK	Phosphopantetheine Adenylyltransferase from Mycobacterium tuberculosis in complex with 4'-phosphopantetheine 分子名称: 4'-PHOSPHOPANTETHEINE, NICKEL (II) ION, Phosphopantetheine adenylyltransferase 著者 Wubben, T.J, Mesecar, A.D. 登録日 2010-06-03 公開日 2010-09-15 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Kinetic, thermodynamic, and structural insight into the mechanism of phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis. J.Mol.Biol., 404, 2010
6CI9	RMM microcompartment-associated aminopropanol dehydrogenase NADP + aminoacetone holo-structure 分子名称: 1-aminopropan-2-one, 3-oxoacyl-[acyl-carrier-protein] reductase, CHLORIDE ION, ... 著者 Mallette, E, Kimber, M.S. 登録日 2018-02-23 公開日 2018-05-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure and Kinetics of the S-(+)-1-Amino-2-propanol Dehydrogenase from the RMM Microcompartment of Mycobacterium smegmatis. Biochemistry, 57, 2018
2I7N	Crystal structure of human PANK1 alpha: the catalytic core domain in complex with AcCoA 分子名称: ACETYL COENZYME *A, Pantothenate kinase 1 著者 Hong, B.S, Wang, L, Tempel, W, Loppnau, P, Allali-Hassani, A, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H.W. 登録日 2006-08-31 公開日 2006-12-26 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder. J.Biol.Chem., 282, 2007
2GJN	crystal structure of 2-nitropropane dioxygenase complexed with FMN and substrate 分子名称: 2-NITROPROPANE, FLAVIN MONONUCLEOTIDE, hypothetical protein PA1024 著者 Suh, S.W. 登録日 2006-03-31 公開日 2006-05-16 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal Structure of 2-Nitropropane Dioxygenase Complexed with FMN and Substrate: identification of the catalytic base J.Biol.Chem., 281, 2006
3BEX	Type III pantothenate kinase from Thermotoga maritima complexed with pantothenate 分子名称: PANTOTHENOIC ACID, PHOSPHATE ION, Type III pantothenate kinase 著者 Yang, K, Huerta, C, Strauss, E, Zhang, H. 登録日 2007-11-20 公開日 2008-06-24 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.51 Å) 主引用文献 Structural basis for substrate binding and the catalytic mechanism of type III pantothenate kinase. Biochemistry, 47, 2008
6W29	Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC013) 分子名称: 3,5-bis(fluoranyl)-~{N}-[3-[(4-methoxyphenyl)sulfamoyl]phenyl]benzamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CITRIC ACID, ... 著者 Mercaldi, G.F, Fagundes, M, Faria, J.N, Cordeiro, A.T. 登録日 2020-03-05 公開日 2021-03-10 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box. Acs Infect Dis., 7, 2021
6W2N	Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC009) 分子名称: 3,5-bis(fluoranyl)-~{N}-[3-[(2-fluoranyl-4-methoxy-phenyl)sulfamoyl]phenyl]benzamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CITRIC ACID, ... 著者 Mercaldi, G.F, Fagundes, M, Faria, J.N, Cordeiro, A.T. 登録日 2020-03-06 公開日 2021-03-10 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box. Acs Infect Dis., 7, 2021
6W59	Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC063) 分子名称: 3,5-bis(fluoranyl)-~{N}-[3-[[4-(trifluoromethyloxy)phenyl]sulfamoyl]phenyl]benzamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Malic enzyme 著者 Mercaldi, G.F, Fagundes, M, Faria, J.N, Cordeiro, A.T. 登録日 2020-03-12 公開日 2021-03-17 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box. Acs Infect Dis., 7, 2021
6W49	Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC010) 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CITRIC ACID, Malic enzyme, ... 著者 Mercaldi, G.F, Fagundes, M, Faria, J.N, Cordeiro, A.T. 登録日 2020-03-10 公開日 2021-04-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box. Acs Infect Dis., 7, 2021
6W57	Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC069) 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Malic enzyme, ~{N}-[5-[[4-[bis(fluoranyl)methoxy]phenyl]sulfamoyl]-2-chloranyl-phenyl]-3,5-bis(fluoranyl)benzamide 著者 Mercaldi, G.F, Fagundes, M, Faria, J.N, Cordeiro, A.T. 登録日 2020-03-12 公開日 2021-04-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box. Acs Infect Dis., 7, 2021
6W53	Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC070) 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Malic enzyme, N-(2-chloro-5-{[4-(trifluoromethoxy)phenyl]sulfamoyl}phenyl)-3,5-difluorobenzamide 著者 Mercaldi, G.F, Fagundes, M, Faria, J.N, Cordeiro, A.T. 登録日 2020-03-12 公開日 2021-04-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box. Acs Infect Dis., 7, 2021
6W56	Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC062) 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Malic enzyme, ~{N}-[3-[[4-[bis(fluoranyl)methoxy]phenyl]sulfamoyl]phenyl]-3,5-bis(fluoranyl)benzamide 著者 Mercaldi, G.F, Fagundes, M, Faria, J.N, Cordeiro, A.T. 登録日 2020-03-12 公開日 2021-04-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box. Acs Infect Dis., 7, 2021
8RD2	Trypanosoma brucei Invariant Surface Glycoprotein 75 (ISG75) 分子名称: Invariant surface glycoprotein 著者 Stodkilde-Jorgensen, K, Mikkelsen, J.H. 登録日 2023-12-07 公開日 2024-02-14 最終更新日 2024-04-10 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Trypanosoma brucei Invariant Surface Glycoprotein 75 Is an Immunoglobulin Fc Receptor Inhibiting Complement Activation and Antibody-Mediated Cellular Phagocytosis. J Immunol., 212, 2024
2I7P	Crystal structure of human PANK3 in complex with AcCoA 分子名称: ACETYL COENZYME *A, Pantothenate kinase 3 著者 Hong, B.S, Wang, L, Shen, L, Tempel, W, Loppnau, P, Finerty, P, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H.W, Structural Genomics Consortium (SGC) 登録日 2006-08-31 公開日 2006-12-26 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder. J.Biol.Chem., 282, 2007
6SR7	Structure of the U1A variant A1-98 Y31H/Q36R/K98W 分子名称: SULFATE ION, U1 small nuclear ribonucleoprotein A 著者 Rosenbach, H, Span, I. 登録日 2019-09-05 公開日 2020-05-13 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Expanding crystallization tools for nucleic acid complexes using U1A protein variants. J.Struct.Biol., 210, 2020
6SQV	Structure of the U1A variant A1-98 Y31H/Q36R/R70W 分子名称: SULFATE ION, U1 small nuclear ribonucleoprotein A 著者 Rosenbach, H, Span, I. 登録日 2019-09-04 公開日 2020-05-13 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Expanding crystallization tools for nucleic acid complexes using U1A protein variants. J.Struct.Biol., 210, 2020
6SQT	Structure of the U1A variant A1-98 Y31H/Q36R/F56W triple mutant 分子名称: U1 small nuclear ribonucleoprotein A 著者 Rosenbach, H, Span, I. 登録日 2019-09-04 公開日 2020-05-13 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Expanding crystallization tools for nucleic acid complexes using U1A protein variants. J.Struct.Biol., 210, 2020
6SQN	Structure of the U1A variant A1-98 Y31H/Q36R/F56W triple mutant co-crystallized with RNA 分子名称: RNA hairpin, U1 small nuclear ribonucleoprotein A 著者 Rosenbach, H, Span, I. 登録日 2019-09-04 公開日 2020-05-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Expanding crystallization tools for nucleic acid complexes using U1A protein variants. J.Struct.Biol., 210, 2020
6SQQ	Structure of the U1A variant A1-98 Y31H/Q36R/F56W triple mutant in complex with RNA obtained by soaking 分子名称: MAGNESIUM ION, RNA hairpin, U1 small nuclear ribonucleoprotein A 著者 Rosenbach, H, Span, I. 登録日 2019-09-04 公開日 2020-05-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.37 Å) 主引用文献 Expanding crystallization tools for nucleic acid complexes using U1A protein variants. J.Struct.Biol., 210, 2020
7F8O	Cryo-EM structure of the C-terminal deletion mutant of human PANX1 in a nanodisc 分子名称: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Pannexin-1 著者 Kuzuya, M, Hirano, H, Hayashida, K, Watanabe, M, Kobayashi, K, Tani, K, Fujiyoshi, Y, Oshima, A. 登録日 2021-07-02 公開日 2022-01-26 最終更新日 2022-02-23 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids. Sci.Signal., 15, 2022
3QFX	Trypanosoma brucei dihydrofolate reductase pyrimethamine complex 分子名称: 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE, Bifunctional dihydrofolate reductase-thymidylate synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Vanichtanankul, J, Yuvaniyama, J, Taweechai, S, Chitnumsub, P, Kamchonwongpaisan, S, Yuthavong, Y. 登録日 2011-01-24 公開日 2011-06-29 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Trypanosomal dihydrofolate reductase reveals natural antifolate resistance Acs Chem.Biol., 6, 2011

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