6W49

Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC010)

Summary for 6W49

• Entry DOI: 10.2210/pdb6w49/pdb
• Descriptor: Malic enzyme, CITRIC ACID, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (5 entities in total)
• Functional Keywords: inhibitor, complex, isomerase, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• Biological source: Trypanosoma cruzi
• Total number of polymer chains: 1
• Total formula weight: 62413.21

Authors

Mercaldi, G.F.,Fagundes, M.,Faria, J.N.,Cordeiro, A.T. (deposition date: 2020-03-10, release date: 2021-04-07, Last modification date: 2023-10-18)

• Primary citation: Mercaldi, G.F.,Eufrasio, A.G.,Ranzani, A.T.,do Nascimento Faria, J.,Mota, S.G.R.,Fagundes, M.,Bruder, M.,Cordeiro, A.T.; Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box.; Acs Infect Dis., 7:2455-2471, 2021; PubMed: 34279922; DOI: 10.1021/acsinfecdis.1c00231

Experimental method

X-RAY DIFFRACTION (1.7 Å)