6W59

Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC063)

Summary for 6W59

Entry DOI	10.2210/pdb6w59/pdb
Descriptor	Malic enzyme, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 3,5-bis(fluoranyl)-~{N}-[3-[[4-(trifluoromethyloxy)phenyl]sulfamoyl]phenyl]benzamide, ... (4 entities in total)
Functional Keywords	inhibitor, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
Biological source	Trypanosoma cruzi
Total number of polymer chains	1
Total formula weight	62321.10
Authors	Mercaldi, G.F.,Fagundes, M.,Faria, J.N.,Cordeiro, A.T. (deposition date: 2020-03-12, release date: 2021-03-17, Last modification date: 2023-10-18)
Primary citation	Mercaldi, G.F.,Eufrasio, A.G.,Ranzani, A.T.,do Nascimento Faria, J.,Mota, S.G.R.,Fagundes, M.,Bruder, M.,Cordeiro, A.T. Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box. Acs Infect Dis., 7:2455-2471, 2021 Cited by PubMed: 34279922 DOI: 10.1021/acsinfecdis.1c00231 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation