4XRJ
| Crystal structure of ERK2 in complex with an inhibitor | 分子名称: | Mitogen-activated protein kinase 1, N~1~-[3-(benzyloxy)benzyl]-1H-tetrazole-1,5-diamine, SULFATE ION | 著者 | Gelin, M, Allemand, F, Labesse, G, Guichou, J.F. | 登録日 | 2015-01-21 | 公開日 | 2015-08-12 | 最終更新日 | 2015-08-19 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography. Acta Crystallogr.,Sect.D, 71, 2015
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7S4E
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6SIS
| Crystal structure of macrocyclic PROTAC 1 in complex with the second bromodomain of human Brd4 and pVHL:ElonginC:ElonginB | 分子名称: | Bromodomain-containing protein 4, Elongin-B, Elongin-C, ... | 著者 | Hughes, S.J, Testa, A, Ciulli, A. | 登録日 | 2019-08-10 | 公開日 | 2019-12-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Structure-Based Design of a Macrocyclic PROTAC. Angew.Chem.Int.Ed.Engl., 59, 2020
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3MVM
| P38 Alpha Map Kinase complexed with pyrrolotriazine inhibitor 7V | 分子名称: | 4-{[5-(isoxazol-3-ylcarbamoyl)-2-methylphenyl]amino}-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide, Mitogen-activated protein kinase 14 | 著者 | Sack, J.S. | 登録日 | 2010-05-04 | 公開日 | 2010-10-13 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Discovery of 4-(5-(Cyclopropylcarbamoyl)-2-Methylphenylamino)-5-Methyl-Npropylpyrrolo[1,2-F][1,2,4] Triazine-6-Carboxamide (Bms-582949), a Clinical P38? Map Kinase Inhibitor for the Treatment of Inflammatory Diseases J.Med.Chem., 53, 2010
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3MVL
| P38 Alpha Map Kinase complexed with pyrrolotriazine inhibitor 7K | 分子名称: | 4-{[5-(cyclopropylcarbamoyl)-2-methylphenyl]amino}-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide, Mitogen-activated protein kinase 14 | 著者 | Sack, J.S. | 登録日 | 2010-05-04 | 公開日 | 2010-10-13 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Discovery of 4-(5-(Cyclopropylcarbamoyl)-2-Methylphenylamino)-5-Methyl-Npropylpyrrolo[1,2-F][1,2,4] Triazine-6-Carboxamide (Bms-582949), a Clinical P38 Map Kinase Inhibitor for the Treatment of Inflammatory Diseases J.Med.Chem., 53, 2010
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8PEP
| H3K36me2 nucleosome-LEDGF/p75 PWWP domain complex - pose 2 | 分子名称: | Histone H2A, Histone H2B 1.1, Histone H3, ... | 著者 | Koutna, E, Kouba, T, Veverka, V. | 登録日 | 2023-06-14 | 公開日 | 2023-08-16 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.33 Å) | 主引用文献 | Multivalency of nucleosome recognition by LEDGF. Nucleic Acids Res., 51, 2023
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6R3S
| CRYSTAL STRUCTURE OF CDK8-CycC IN COMPLEX WITH COMPOUND 1 | 分子名称: | 1,2-ETHANEDIOL, 6-[5-chloranyl-4-[(1~{S})-1-oxidanylethyl]pyridin-3-yl]-3,4-dihydro-2~{H}-1,8-naphthyridine-1-carboxamide, Cyclin-C, ... | 著者 | Boettcher, J. | 登録日 | 2019-03-21 | 公開日 | 2020-04-08 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance. Mol.Cancer Ther., 19, 2020
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7QPD
| Structure of the human MHC I peptide-loading complex editing module | 分子名称: | Beta-2-microglobulin, Calreticulin, HLA class I histocompatibility antigen, ... | 著者 | Domnick, A, Susac, L, Trowitzsch, S, Thomas, C, Tampe, R. | 登録日 | 2022-01-03 | 公開日 | 2022-07-20 | 最終更新日 | 2022-08-24 | 実験手法 | ELECTRON MICROSCOPY (3.73 Å) | 主引用文献 | Molecular basis of MHC I quality control in the peptide loading complex. Nat Commun, 13, 2022
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8OSJ
| Cryo-EM structure of CLOCK-BMAL1 bound to a nucleosomal E-box at position SHL-6.2 (DNA conformation 1) | 分子名称: | Basic helix-loop-helix ARNT-like protein 1, Circadian locomoter output cycles protein kaput, DNA (124-MER), ... | 著者 | Michael, A.K, Stoos, L, Kempf, G, Cavadini, S, Thoma, N.H. | 登録日 | 2023-04-19 | 公開日 | 2023-05-24 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (6.2 Å) | 主引用文献 | Cooperation between bHLH transcription factors and histones for DNA access. Nature, 619, 2023
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8OSL
| Cryo-EM structure of CLOCK-BMAL1 bound to the native Por enhancer nucleosome (map 2, additional 3D classification and flexible refinement) | 分子名称: | Basic helix-loop-helix ARNT-like protein 1, Circadian locomoter output cycles protein kaput, DNA (147-MER), ... | 著者 | Michael, A.K, Stoos, L, Kempf, G, Cavadini, S, Thoma, N. | 登録日 | 2023-04-19 | 公開日 | 2023-05-24 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | 主引用文献 | Cooperation between bHLH transcription factors and histones for DNA access. Nature, 619, 2023
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8OSK
| Cryo-EM structure of CLOCK-BMAL1 bound to a nucleosomal E-box at position SHL+5.8 (composite map) | 分子名称: | Basic helix-loop-helix ARNT-like protein 1, Circadian locomoter output cycles protein kaput, DNA (124-MER), ... | 著者 | Stoos, L, Michael, A.K, Kempf, G, Cavadini, S, Thoma, N.H. | 登録日 | 2023-04-19 | 公開日 | 2023-05-24 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Cooperation between bHLH transcription factors and histones for DNA access. Nature, 619, 2023
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4XP3
| Crystal structure of ERK2 in complex with an inhibitor | 分子名称: | 2-amino-1,9-dihydro-6H-purine-6-thione, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ... | 著者 | Gelin, M, Allemand, F, Labesse, G, Guichou, J.F. | 登録日 | 2015-01-16 | 公開日 | 2015-08-12 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.782 Å) | 主引用文献 | Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography. Acta Crystallogr.,Sect.D, 71, 2015
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3UVQ
| Human p38 MAP Kinase in Complex with a Dibenzosuberone Derivative | 分子名称: | Mitogen-activated protein kinase 14, N-{5-[(7-{[(2R)-2,3-dihydroxypropyl]oxy}-5-oxo-10,11-dihydro-5H-dibenzo[a,d][7]annulen-2-yl)amino]-2-fluorophenyl}benzamide, octyl beta-D-glucopyranoside | 著者 | Mayer-Wrangowski, S.C, Richters, A, Gruetter, C, Rauh, D. | 登録日 | 2011-11-30 | 公開日 | 2012-12-05 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Dibenzosuberones as p38 mitogen-activated protein kinase inhibitors with low ATP competitiveness and outstanding whole blood activity. J.Med.Chem., 56, 2013
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4MK1
| 5-bromopyridine-2,3-diol bound to influenza 2009 pH1N1 endonuclease | 分子名称: | 1,2-ETHANEDIOL, 5-bromo-3-hydroxypyridin-2(1H)-one, MANGANESE (II) ION, ... | 著者 | Bauman, J.D, Patel, D, Das, K, Arnold, E. | 登録日 | 2013-09-04 | 公開日 | 2013-09-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors. Acs Chem.Biol., 8, 2013
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7VOI
| Structure of the human CNOT1(MIF4G)-CNOT6L-CNOT7 complex | 分子名称: | CCR4-NOT transcription complex subunit 1, CCR4-NOT transcription complex subunit 6-like, CCR4-NOT transcription complex subunit 7 | 著者 | Bartlam, M, Zhang, Q. | 登録日 | 2021-10-13 | 公開日 | 2022-06-01 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (4.38 Å) | 主引用文献 | Structure of the human Ccr4-Not nuclease module using X-ray crystallography and electron paramagnetic resonance spectroscopy distance measurements. Protein Sci., 31, 2022
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4WW5
| Crystal structure of binary complex Bud32-Cgi121 in complex with AMPP | 分子名称: | ACETATE ION, EKC/KEOPS complex subunit BUD32, EKC/KEOPS complex subunit CGI121, ... | 著者 | Zhang, W. | 登録日 | 2014-11-10 | 公開日 | 2015-03-18 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.997 Å) | 主引用文献 | Crystal structures of the Gon7/Pcc1 and Bud32/Cgi121 complexes provide a model for the complete yeast KEOPS complex. Nucleic Acids Res., 43, 2015
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4WW9
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7TYR
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8EWV
| DNA-encoded library (DEL)-enabled discovery of proximity inducing small molecules | 分子名称: | Bromodomain-containing protein 4, Elongin-B, Elongin-C, ... | 著者 | Schreiber, S.L, Shu, W, Ma, X, Michaud, G, Bonazzi, S, Berst, F. | 登録日 | 2022-10-24 | 公開日 | 2023-10-04 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | DNA-encoded library-enabled discovery of proximity-inducing small molecules. Nat.Chem.Biol., 20, 2024
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8I53
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4MK2
| 3-(5-hydroxy-6-oxo-1,6-dihydropyridin-3-yl)benzonitrile bound to influenza 2009 pH1N1 endonuclease | 分子名称: | 1,2-ETHANEDIOL, 3-(5-hydroxy-6-oxo-1,6-dihydropyridin-3-yl)benzonitrile, MANGANESE (II) ION, ... | 著者 | Bauman, J.D, Patel, D, Das, K, Arnold, E. | 登録日 | 2013-09-04 | 公開日 | 2013-09-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors. Acs Chem.Biol., 8, 2013
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4MWH
| Crystal structure of scCK2 alpha in complex with ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Casein kinase II subunit alpha, MAGNESIUM ION, ... | 著者 | Liu, H. | 登録日 | 2013-09-24 | 公開日 | 2013-11-20 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | The multiple nucleotide-divalent cation binding modes of Saccharomyces cerevisiae CK2 alpha indicate a possible co-substrate hydrolysis product (ADP/GDP) release pathway. Acta Crystallogr.,Sect.D, 70, 2014
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3FQG
| Crystal Structure of the S. pombe Rai1 | 分子名称: | MAGNESIUM ION, Protein din1 | 著者 | Xiang, S, Tong, L. | 登録日 | 2009-01-07 | 公開日 | 2009-02-03 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1. Nature, 458, 2009
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3FQD
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2HHU
| C:O6-methyl-guanine in the polymerase postinsertion site (-1 basepair position) | 分子名称: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*GP*CP*GP*AP*TP*CP*AP*GP*CP*CP*C)-3', 5'-D(*GP*TP*AP*CP*(6OG)P*GP*GP*CP*TP*GP*AP*TP*CP*GP*CP*A)-3', ... | 著者 | Warren, J.J, Forsberg, L.J, Beese, L.S. | 登録日 | 2006-06-28 | 公開日 | 2006-12-12 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | The structural basis for the mutagenicity of O6-methyl-guanine lesions. Proc.Natl.Acad.Sci.Usa, 103, 2006
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