1D20
 
 | | SOLUTION STRUCTURE OF PHAGE LAMBDA HALF-OPERATOR DNA | | 分子名称: | DNA (5'-D(*CP*GP*GP*TP*GP*AP*TP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*TP*CP*AP*CP*CP*G)-3') | | 著者 | Baleja, J.D, Sykes, B.D. | | 登録日 | 1990-08-01 | | 公開日 | 1991-07-15 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of phage lambda half-operator DNA by use of NMR, restrained molecular dynamics, and NOE-based refinement.
Biochemistry, 29, 1990
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6P4B
 | | HyHEL10 fab variant HyHEL10-4x (heavy chain mutations L4F, Y33H, S56N, and Y58F) bound to hen egg lysozyme variant HEL2x-flex (mutations R21Q, R73E, C76S, and C94S) | | 分子名称: | CHLORIDE ION, HyHEL10 Fab heavy chain, HyHEL10 Fab light chain, ... | | 著者 | Langley, D.B, Christ, D. | | 登録日 | 2019-05-27 | | 公開日 | 2020-05-27 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens.
Proc.Natl.Acad.Sci.USA, 117, 2020
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5YCW
 | | Double domain swapped dimer of engineered hairpin loop1 and loop3 mutant in Single-chain Monellin | | 分子名称: | single chain monellin | | 著者 | Surana, P, Nandwani, N, Udgaonkar, J.B, Gosavi, S, Das, R. | | 登録日 | 2017-09-08 | | 公開日 | 2018-11-28 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.285 Å) | | 主引用文献 | A five-residue motif for the design of domain swapping in proteins.
Nat Commun, 10, 2019
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3OF1
 | | Crystal Structure of Bcy1, the Yeast Regulatory Subunit of PKA | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, cAMP-dependent protein kinase regulatory subunit | | 著者 | Rinaldi, J, Wu, J, Yang, J, Ralston, C.Y, Sankaran, B, Moreno, S, Taylor, S.S. | | 登録日 | 2010-08-13 | | 公開日 | 2010-12-01 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | Structure of Yeast Regulatory Subunit: A Glimpse into the Evolution of PKA Signaling.
Structure, 18, 2010
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4KXO
 | | Crystal Structure of BBBB at pH 10.0 with MPD as the cryoprotectant | | 分子名称: | Histo-blood group ABO system transferase | | 著者 | Johal, A.R, Blackler, R.J, Alfaro, J.A, Schuman, B, Borisova, S.N, Evans, S.V. | | 登録日 | 2013-05-27 | | 公開日 | 2014-04-09 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | pH-induced conformational changes in human ABO(H) blood group glycosyltransferases confirm the importance of electrostatic interactions in the formation of the semi-closed state.
Glycobiology, 24, 2014
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3K9P
 | | The crystal structure of E2-25K and ubiquitin complex | | 分子名称: | Ubiquitin, Ubiquitin-conjugating enzyme E2 K | | 著者 | Kang, G.B, Ko, S, Song, S.M, Lee, W, Eom, S.H. | | 登録日 | 2009-10-16 | | 公開日 | 2010-09-08 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural basis of E2-25K/UBB+1 interaction leading to proteasome inhibition and neurotoxicity
J.Biol.Chem., 285, 2010
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3OHR
 | | Crystal structure of fructokinase from bacillus subtilis complexed with ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Putative fructokinase, SULFATE ION, ... | | 著者 | Nocek, B, Volkart, L, Cuff, M, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2010-08-17 | | 公開日 | 2010-09-15 | | 最終更新日 | 2012-10-10 | | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | | 主引用文献 | Structural studies of ROK fructokinase YdhR from Bacillus subtilis: insights into substrate binding and fructose specificity.
J.Mol.Biol., 406, 2011
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5UAB
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4NLU
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3K9Z
 | | Rational Design of a Structural and Functional Nitric Oxide Reductase | | 分子名称: | FE (II) ION, Myoglobin, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Yeung, N, Lin, Y.-W, Gao, Y.-G, Zhao, X, Russell, B.S, Lei, L, Miner, K.D, Robinson, H, Lu, Y. | | 登録日 | 2009-10-16 | | 公開日 | 2009-12-01 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | Rational design of a structural and functional nitric oxide reductase.
Nature, 462, 2009
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4NLW
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4NLV
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4NLY
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6F1N
 | | Estimation of relative drug-target residence times by random acceleration molecular dynamics simulation | | 分子名称: | 4-[5-[2-aminocarbonyl-3,6-bis(azanyl)-5-cyano-thieno[2,3-b]pyridin-4-yl]-2-methoxy-phenoxy]butanoic acid, Heat shock protein HSP 90-alpha, SULFATE ION | | 著者 | Musil, D, Lehmann, M, Eggenweiler, H.-M. | | 登録日 | 2017-11-22 | | 公開日 | 2018-05-30 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | Estimation of Drug-Target Residence Times by tau-Random Acceleration Molecular Dynamics Simulations.
J Chem Theory Comput, 14, 2018
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2EAO
 | | Solution structure of the C-terminal SAM-domain of mouse ephrin type-B receptor 1 precursor (EC 2.7.1.112) | | 分子名称: | Ephrin type-B receptor 1 | | 著者 | Goroncy, A.K, Sato, M, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2007-01-31 | | 公開日 | 2007-07-31 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the C-terminal SAM-domain of mouse ephrin type-B receptor 1 precursor (EC 2.7.1.112)
To be Published
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5UAD
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7UY8
 | | Tetrahymena Polymerase alpha-Primase | | 分子名称: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | | 著者 | He, Y, Song, H, Chan, H, Wang, Y, Liu, B, Susac, L, Zhou, Z.H, Feigon, J. | | 登録日 | 2022-05-06 | | 公開日 | 2022-07-13 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Structure of Tetrahymena telomerase-bound CST with polymerase alpha-primase.
Nature, 608, 2022
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8BQW
 | | Cryo-EM structure of alpha-synuclein filaments doublet from Juvenile-onset synucleinopathy | | 分子名称: | Alpha-synuclein, Unknown protein | | 著者 | Yang, Y, Garringer, J.H, Shi, Y, Lovestam, S, Peak-Chew, S.Y, Zhang, X.J, Kotecha, A, Bacioglu, M, Koto, A, Takao, M, Spillantini, G.M, Ghetti, B, Vidal, R, Murzin, G.A, Scheres, H.W.S, Goedert, M. | | 登録日 | 2023-01-18 | | 公開日 | 2023-02-22 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | | 主引用文献 | New SNCA mutation and structures of alpha-synuclein filaments from juvenile-onset synucleinopathy.
Acta Neuropathol, 145, 2023
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6XZ1
 | | Conjugate of the HECT domain of HUWE1 with ubiquitin | | 分子名称: | HECT, UBA and WWE domain containing 1, isoform CRA_a, ... | | 著者 | Liu, B, Seenivasan, A, Nair, R, Chen, D, Lowe, E.D, Lorenz, S. | | 登録日 | 2020-01-31 | | 公開日 | 2021-08-25 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Reconstitution and Structural Analysis of a HECT Ligase-Ubiquitin Complex via an Activity-Based Probe.
Acs Chem.Biol., 16, 2021
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4YD0
 | | Influenza polymerase basic protein 2 (PB2) bound to an azaindole-tetrazole inhibitor | | 分子名称: | 2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoro-N-[(1R,2S,3S,4R)-3-(1H-tetrazol-5-yl)bicyclo[2.2.2]oct-2-yl]pyrimidin-4-amine, Polymerase basic protein 2 | | 著者 | Jacobs, M.D. | | 登録日 | 2015-02-20 | | 公開日 | 2015-04-15 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | | 主引用文献 | Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors.
Bioorg.Med.Chem.Lett., 25, 2015
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7MCE
 | | CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH 2-{(7P)-7-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-8-fluoro-5-[(S)-(oxan-4-yl)(phenyl)methyl]-5H-pyrido[3,2-b]indol-3-yl}propan-2-ol | | 分子名称: | 2-{(7P)-7-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-8-fluoro-5-[(S)-(oxan-4-yl)(phenyl)methyl]-5H-pyrido[3,2-b]indol-3-yl}propan-2-ol, Bromodomain-containing protein 4 | | 著者 | Sheriff, S. | | 登録日 | 2021-04-02 | | 公開日 | 2021-09-29 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Development of BET inhibitors as potential treatments for cancer: A new carboline chemotype.
Bioorg.Med.Chem.Lett., 51, 2021
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7M2F
 | | CDK2 with compound 14 inhibitor with carboxylate | | 分子名称: | Cyclin-dependent kinase 2, [(1r,4r)-4-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}cyclohexyl]acetic acid | | 著者 | Longenecker, K.L, Qiu, W, Korepanova, A, Tong, Y. | | 登録日 | 2021-03-16 | | 公開日 | 2021-07-07 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.632 Å) | | 主引用文献 | Balancing Properties with Carboxylates: A Lead Optimization Campaign for Selective and Orally Active CDK9 Inhibitors.
Acs Med.Chem.Lett., 12, 2021
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5T9B
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1DDP
 | | Solution structure of a CISPLATIN-INDUCED [CATAGCTATG]2 Interstrand cross-link | | 分子名称: | Cisplatin, DNA (5'-D(*CP*AP*TP*AP*GP*CP*TP*AP*TP*G)-3') | | 著者 | Zhu, L, Huang, H, Reid, B.R, Drobny, G.P, Hopkins, P.B. | | 登録日 | 1995-10-26 | | 公開日 | 1996-03-08 | | 最終更新日 | 2024-03-13 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of a cisplatin-induced DNA interstrand cross-link.
Science, 270, 1995
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6BXJ
 | | Structure of a single-chain beta3 integrin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Chimera protein of Integrin beta-3 and Integrin alpha-L, MAGNESIUM ION | | 著者 | Thinn, A.M.M, Wang, Z, Zhou, D, Zhao, Y, Curtis, B.R, Zhu, J. | | 登録日 | 2017-12-18 | | 公開日 | 2018-10-03 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.092 Å) | | 主引用文献 | Autonomous conformational regulation of beta3integrin and the conformation-dependent property of HPA-1a alloantibodies.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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