5UAD

MET Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of an HGF Antibody

Summary for 5UAD

• Entry DOI: 10.2210/pdb5uad/pdb
• Related: 5UAB 5UAF
• Descriptor: Hepatocyte growth factor receptor, N-(6-{[6-(1-methyl-1H-pyrazol-4-yl)-1H-benzotriazol-1-yl]methyl}imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: met, tyrosine kinase, inhibitor, antitumor, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581
• Total number of polymer chains: 1
• Total formula weight: 39027.39

Authors

Hoffman, I.D.,Lawson, J.D. (deposition date: 2016-12-19, release date: 2017-05-31, Last modification date: 2024-03-06)

• Primary citation: Farrell, P.J.,Matuszkiewicz, J.,Balakrishna, D.,Pandya, S.,Hixon, M.S.,Kamran, R.,Chu, S.,Lawson, J.D.,Okada, K.,Hori, A.,Mizutani, A.,Iwata, H.,de Jong, R.,Hibner, B.,Vincent, P.; MET Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of an HGF Antibody.; Mol. Cancer Ther., 16:1269-1278, 2017; PubMed: 28341789; DOI: 10.1158/1535-7163.MCT-16-0771

Experimental method

X-RAY DIFFRACTION (2.25 Å)