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6UBW

MET Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of an HGF Antibody

Replaces:  5UAF
Summary for 6UBW
Entry DOI10.2210/pdb6ubw/pdb
DescriptorHepatocyte growth factor receptor, N-(6-{difluoro[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]methyl}imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide, CHLORIDE ION, ... (4 entities in total)
Functional Keywordsmet, tyrosine kinase, inhibitor, antitumor, transferase-transferase inhibitor complex, transferase-transferase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight39063.37
Authors
Hoffman, I.D.,Lawson, J.D. (deposition date: 2019-09-13, release date: 2020-02-12, Last modification date: 2021-08-25)
Primary citationFarrell, P.J.,Matuszkiewicz, J.,Balakrishna, D.,Pandya, S.,Hixon, M.S.,Kamran, R.,Chu, S.,Lawson, J.D.,Okada, K.,Hori, A.,Mizutani, A.,Iwata, H.,de Jong, R.,Hibner, B.,Vincent, P.
MET Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of an HGF Antibody.
Mol.Cancer Ther., 16:1269-1278, 2017
Cited by
PubMed: 28341789
DOI: 10.1158/1535-7163.MCT-16-0771
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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