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6UBW

MET Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of an HGF Antibody

Replaces:  5UAF
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AHepatocyte growth factor receptorpolymer34338578.51UniProt (P08581)
Pfam (PF07714)
In PDB
Homo sapiens (Human)HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met
2AN-(6-{difluoro[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]methyl}imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamidenon-polymer449.41Chemie (84S)
3ACHLORIDE IONnon-polymer35.51Chemie (CL)
4waterwater18.0166Chemie (HOH)
Sequence modifications
A: 1024 - 1360 (UniProt: P08581)
PDBExternal DatabaseDetails
Gly 1019-expression tag
Ala 1020-expression tag
Met 1021-expression tag
Gly 1022-expression tag
Ser 1023-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight38578.5
Non-Polymers*Number of molecules2
Total formula weight484.9
All*Total formula weight39063.4
*Water molecules are not included.

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PDB entries from 2024-04-24

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