7MCE
CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH 2-{(7P)-7-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-8-fluoro-5-[(S)-(oxan-4-yl)(phenyl)methyl]-5H-pyrido[3,2-b]indol-3-yl}propan-2-ol
Summary for 7MCE
Entry DOI | 10.2210/pdb7mce/pdb |
Descriptor | Bromodomain-containing protein 4, 2-{(7P)-7-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-8-fluoro-5-[(S)-(oxan-4-yl)(phenyl)methyl]-5H-pyrido[3,2-b]indol-3-yl}propan-2-ol (3 entities in total) |
Functional Keywords | bromodomain-containing protein 4 isoform long, brd4, bromodomain containing protein 4, cap, hunk1, mcap, mitotic chromosome associated protein sgc, cell cycle |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 15721.10 |
Authors | Sheriff, S. (deposition date: 2021-04-02, release date: 2021-09-29, Last modification date: 2023-10-18) |
Primary citation | Hill, M.D.,Quesnelle, C.,Tokarski, J.,Fang, H.,Fanslau, C.,Haarhoff, Z.,Kramer, M.,Madari, S.,Wiebesiek, A.,Morrison, J.,Simmermacher-Mayer, J.,Sinz, M.,Westhouse, R.,Xie, C.,Zhao, J.,Huang, L.,Sheriff, S.,Yan, C.,Marsilio, F.,Everlof, G.,Zvyaga, T.,Lee, F.,Gavai, A.V.,Degnan, A.P. Development of BET inhibitors as potential treatments for cancer: A new carboline chemotype. Bioorg.Med.Chem.Lett., 51:128376-128376, 2021 Cited by PubMed: 34560263DOI: 10.1016/j.bmcl.2021.128376 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.76 Å) |
Structure validation
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