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5IF2
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Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to fragment hit EBSI-576 (5,6-dichloro-1H-1,3-benzodiazol-2-yl)methanol
分子名称: (5,6-dichloro-1H-benzimidazol-2-yl)methanol, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2016-02-25
公開日2017-02-22
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Fragment screening by STD NMR identifies novel site binders against influenza A virus polymerase PA
To Be Published
3SPY
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BU of 3spy by Molmil
RB69 DNA Polymerase(L415A/L561A/S565G/Y567A) Ternary Complex with dUpCpp Opposite dA
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]uridine, 5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*C)-3', 5'-D(*TP*CP*GP*AP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3', ...
著者Xia, S, Konigsberg, W.H, Wang, J.
登録日2011-07-04
公開日2011-10-12
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Structural Insights into Complete Metal Ion Coordination from Ternary Complexes of B Family RB69 DNA Polymerase.
Biochemistry, 50, 2011
3SQ1
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RB69 DNA Polymerase Ternary Complex with dUpCpp Opposite dA
分子名称: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, 5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*(DOC))-3', 5'-D(*TP*CP*GP*AP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3', ...
著者Xia, S, Konigsberg, W.H, Wang, J.
登録日2011-07-04
公開日2011-10-12
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Structural Insights into Complete Metal Ion Coordination from Ternary Complexes of B Family RB69 DNA Polymerase.
Biochemistry, 50, 2011
6EB9
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Crystal Structure of the Nipah Virus Phosphoprotein Multimerization Domain Delta 542-544
分子名称: Phosphoprotein
著者Bruhn, J.F, Saphire, E.O.
登録日2018-08-06
公開日2019-03-13
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A Conserved Basic Patch and Central Kink in the Nipah Virus Phosphoprotein Multimerization Domain Are Essential for Polymerase Function.
Structure, 27, 2019
6EB8
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Crystal Structure of the Nipah Virus Phosphoprotein Multimerization Domain G519N
分子名称: Phosphoprotein
著者Bruhn, J.F, Saphire, E.O.
登録日2018-08-06
公開日2019-03-13
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献A Conserved Basic Patch and Central Kink in the Nipah Virus Phosphoprotein Multimerization Domain Are Essential for Polymerase Function.
Structure, 27, 2019
2PJP
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BU of 2pjp by Molmil
Structure of the mRNA-binding domain of elongation factor SelB from E.coli in complex with SECIS RNA
分子名称: CALCIUM ION, CHLORIDE ION, MAGNESIUM ION, ...
著者Soler, N, Fourmy, D, Yoshizawa, S.
登録日2007-04-16
公開日2007-10-30
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural insight into a molecular switch in tandem winged-helix motifs from elongation factor SelB.
J.Mol.Biol., 370, 2007
3SQ0
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BU of 3sq0 by Molmil
DNA Polymerase(L561A/S565G/Y567A) Ternary Complex with dUpNpp Opposite dA (Mn2+)
分子名称: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, 5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*(DOC))-3', 5'-D(*TP*CP*AP*AP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3', ...
著者Xia, S, Konigsberg, W.H, Wang, J.
登録日2011-07-04
公開日2011-10-12
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Insights into Complete Metal Ion Coordination from Ternary Complexes of B Family RB69 DNA Polymerase.
Biochemistry, 50, 2011
5KAL
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BU of 5kal by Molmil
Terminal uridylyl transferase 4 from Trypanosoma brucei with bound UTP and UpU
分子名称: MAGNESIUM ION, RNA (5'-R(*UP*U)-3'), RNA uridylyltransferase 4, ...
著者Stagno, J.R, Luecke, H, Afasizhev, R.
登録日2016-06-01
公開日2016-10-26
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献RNA Editing TUTase 1: structural foundation of substrate recognition, complex interactions and drug targeting.
Nucleic Acids Res., 44, 2016
1X9W
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BU of 1x9w by Molmil
T7 DNA polymerase in complex with a primer/template DNA containing a disordered N-2 aminofluorene on the template, crystallized with dideoxy-ATP as the incoming nucleotide.
分子名称: 5'-D(*CP*CP*CP*(AFG)*AP*TP*CP*AP*CP*AP*CP*TP*AP*CP*CP*AP*AP*TP*CP*AP*CP*TP*CP*TP*CP*C)-3', 5'-D(*GP*GP*AP*GP*AP*GP*TP*GP*AP*TP*T*GP*GP*T*AP*GP*TP*GP*TP*GP*AP*(2DT))-3', DNA polymerase, ...
著者Dutta, S, Li, Y, Johnson, D, Dzantiev, L, Richardson, C.C, Romano, L.J, Ellenberger, T.
登録日2004-08-24
公開日2004-10-26
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structures of 2-acetylaminofluorene and 2-aminofluorene in complex with T7 DNA polymerase reveal mechanisms of mutagenesis.
Proc.Natl.Acad.Sci.Usa, 101, 2004
1X9S
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BU of 1x9s by Molmil
T7 DNA polymerase in complex with a primer/template DNA containing a disordered N-2 aminofluorene on the template, crystallized with dideoxy-CTP as the incoming nucleotide.
分子名称: 5'-D(*CP*CP*CP*(AFG)P*AP*TP*CP*AP*CP*AP*CP*TP*AP*CP*CP*AP*AP*TP*CP*AP*CP*TP*CP*TP*CP*C)-3', 5'-D(*GP*GP*AP*GP*AP*GP*TP*GP*AP*TP*T*GP*GP*TP*AP*GP*TP*GP*TP*GP*AP*(2DT))-3', DNA polymerase, ...
著者Dutta, S, Li, Y, Johnson, D, Dzantiev, L, Richardson, C.C, Romano, L.J, Ellenberger, T.
登録日2004-08-24
公開日2004-10-26
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structures of 2-acetylaminofluorene and 2-aminofluorene in complex with T7 DNA polymerase reveal mechanisms of mutagenesis.
Proc.Natl.Acad.Sci.Usa, 101, 2004
3SPZ
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BU of 3spz by Molmil
DNA Polymerase(L415A/L561A/S565G/Y567A) Ternary Complex with dUpCpp Opposite dA (Ca2+)
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]uridine, 5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*C)-3', 5'-D(P*GP*AP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3', ...
著者Xia, S, Konigsberg, W.H, Wang, J.
登録日2011-07-04
公開日2011-10-12
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.43 Å)
主引用文献Structural Insights into Complete Metal Ion Coordination from Ternary Complexes of B Family RB69 DNA Polymerase.
Biochemistry, 50, 2011
3W5Q
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BU of 3w5q by Molmil
Crystal structure of complexes of vitamin D receptor ligand binding domain with lithocholic acid derivatives
分子名称: (5beta,9beta)-3-oxocholan-24-oic acid, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor
著者Masuno, H, Ikura, T, Ito, N.
登録日2013-02-05
公開日2013-06-26
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structures of complexes of vitamin D receptor ligand-binding domain with lithocholic acid derivatives.
J.Lipid Res., 54, 2013
3W5R
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BU of 3w5r by Molmil
Crystal structure of complexes of vitamin D receptor ligand binding domain with lithocholic acid derivatives
分子名称: (3beta,5beta,9beta)-3-(acetyloxy)cholan-24-oic acid, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor
著者Masuno, H, Ikura, T, Ito, N.
登録日2013-02-06
公開日2013-06-26
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structures of complexes of vitamin D receptor ligand-binding domain with lithocholic acid derivatives.
J.Lipid Res., 54, 2013
4H62
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BU of 4h62 by Molmil
Structure of the Saccharomyces cerevisiae Mediator subcomplex Med17C/Med11C/Med22C
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Mediator of RNA polymerase II transcription subunit 11, Mediator of RNA polymerase II transcription subunit 17, ...
著者Lariviere, L, Plaschka, C, Seizl, M, Wenzeck, L, Kurth, F, Cramer, P.
登録日2012-09-19
公開日2012-10-31
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure of the Mediator head module.
Nature, 492, 2012
3W5P
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BU of 3w5p by Molmil
Crystal structure of complexes of vitamin D receptor ligand binding domain with lithocholic acid derivatives
分子名称: (3beta,5beta,14beta,17alpha)-3-hydroxycholan-24-oic acid, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor
著者Masuno, H, Ikura, T, Ito, N.
登録日2013-02-05
公開日2013-06-26
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structures of complexes of vitamin D receptor ligand-binding domain with lithocholic acid derivatives.
J.Lipid Res., 54, 2013
3RJ1
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BU of 3rj1 by Molmil
Architecture of the Mediator Head module
分子名称: Mediator of RNA polymerase II transcription subunit 11, Mediator of RNA polymerase II transcription subunit 17, Mediator of RNA polymerase II transcription subunit 18, ...
著者Imasaki, T, Calero, G, Cai, G, Tsai, K.L, Yamada, K, Cardelli, F, Erdjument-Bromage, H, Tempst, P, Berger, I, Kornberg, G.L, Asturias, F.J, Kornberg, R.D, Takagi, Y.
登録日2011-04-14
公開日2011-07-27
最終更新日2017-08-02
実験手法X-RAY DIFFRACTION (4.3 Å)
主引用文献Architecture of the Mediator head module.
Nature, 475, 2011
3W5T
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BU of 3w5t by Molmil
Crystal structure of complexes of vitamin D receptor ligand binding domain with lithocholic acid derivatives
分子名称: (3beta,5beta,9beta)-3-(propanoyloxy)cholan-24-oic acid, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor
著者Masuno, H, Ikura, T, Ito, N.
登録日2013-02-06
公開日2013-06-26
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Crystal structures of complexes of vitamin D receptor ligand-binding domain with lithocholic acid derivatives.
J.Lipid Res., 54, 2013
1TVA
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BU of 1tva by Molmil
HUMAN DNA POLYMERASE BETA COMPLEXED WITH NICKED DNA CONTAINING A MISMATCHED TEMPLATE THYMIDINE AND INCOMING CYTIDINE
分子名称: 5'-D(*CP*CP*GP*AP*CP*TP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ...
著者Krahn, J.M, Beard, W.A, Wilson, S.H.
登録日2004-06-29
公開日2004-11-23
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural insights into DNA polymerase Beta deterrents for misincorporation support an induced-fit mechanism for fidelity
Structure, 12, 2004
5OXJ
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BU of 5oxj by Molmil
Crystal structure of KlenTaq mutant M747K in a closed ternary complex with a O6-MeG:BenziTP base pair
分子名称: ACETATE ION, DNA polymerase I, thermostable, ...
著者Betz, K, Diederichs, K, Marx, A.
登録日2017-09-06
公開日2017-11-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase.
Chem. Commun. (Camb.), 53, 2017
1ZYQ
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T7 DNA polymerase in complex with 8oG and incoming ddATP
分子名称: 2',3'-DIDEOXYADENOSINE-5'-TRIPHOSPHATE, 5'-D(*CP*CP*CP*(8OG)P*CP*TP*GP*GP*CP*AP*CP*TP*GP*GP*CP*CP*GP*TP*CP*GP*TP*TP*TP*TP*CP*G)-3', 5'-D(*CP*GP*AP*AP*AP*AP*CP*GP*AP*CP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*AP*(DDG))-3', ...
著者Brieba, L.G, Kokoska, R.J, Bebenek, K, Kunkel, T.A, Ellenberger, T.
登録日2005-06-10
公開日2005-11-22
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献A lysine residue in the fingers subdomain of t7 DNA polymerase modulates the miscoding potential of 8-oxo-7,8-dihydroguanosine.
Structure, 13, 2005
5VU6
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TNA polymerase binary complex with primer/template duplex
分子名称: DNA polymerase, DNA template, DNA/TNA hybrid primer
著者Chim, N, Chaput, J.C.
登録日2017-05-18
公開日2017-12-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural basis for TNA synthesis by an engineered TNA polymerase.
Nat Commun, 8, 2017
5IEQ
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BU of 5ieq by Molmil
Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to fragment hit EBSI-747 1-(4-chlorophenyl)-1H-imidazole
分子名称: 1-(4-CHLOROPHENYL)-1H-IMIDAZOLE, DIMETHYL SULFOXIDE, Polymerase acidic protein
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2016-02-25
公開日2017-02-22
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Fragment screening by STD NMR identifies novel site binders against influenza A virus polymerase PA
To Be Published
5IFD
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BU of 5ifd by Molmil
Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to follow on fragment EBSI-4721 1-(4-fluorophenyl)-1H-imidazole
分子名称: 1-(4-fluorophenyl)-1H-imidazole, DIMETHYL SULFOXIDE, Polymerase acidic protein
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2016-02-25
公開日2017-02-22
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Fragment screening by STD NMR identifies novel site binders against influenza A virus polymerase PA
To Be Published
2JEG
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The Molecular Basis of Selectivity of Nucleoside Triphosphate Incorporation Opposite O6-Benzylguanine by Sulfolobus solfataricus DNA Polymerase IV: Steady-state and Pre-steady-state Kinetics and X- Ray Crystallography of Correct and Incorrect Pairing
分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP *TP*TP*CP*DOC)-3', 5'-D(*TP*CP*AP*C BZGP*GP*AP*AP*TP*CP *CP*TP*TP*CP*CP*CP*CP*C)-3', ...
著者Eoff, R.L, Angel, K.C, Kosekov, I.D, Egli, M, Guengerich, F.P.
登録日2007-01-17
公開日2007-03-13
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.38 Å)
主引用文献Molecular Basis of Selectivity of Nucleoside Triphosphate Incorporation Opposite O6-Benzylguanine by Sulfolobus Solfataricus DNA Polymerase Dpo4: Steady-State and Pre-Steady-State Kinetics and X-Ray Crystallography of Correct and Incorrect Pairing.
J.Biol.Chem., 282, 2007
2JEI
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The Molecular Basis of Selectivity of Nucleoside Triphosphate Incorporation Opposite O6-Benzylguanine by Sulfolobus solfataricus DNA Polymerase IV: Steady-state and Pre-steady-state Kinetics and X- Ray Crystallography of Correct and Incorrect Pairing
分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP *TP*TP*CP*T)-3', 5'-D(*TP*CP*AP*C BZGP*GP*AP*AP*TP*CP*CP *TP*TP*CP*CP*CP*CP*C)-3', ...
著者Eoff, R.L, Angel, K.C, Kosekov, I.D, Egli, M, Guengerich, F.P.
登録日2007-01-17
公開日2007-03-13
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Molecular Basis of Selectivity of Nucleoside Triphosphate Incorporation Opposite O6-Benzylguanine by Sulfolobus Solfataricus DNA Polymerase Dpo4: Steady-State and Pre-Steady-State Kinetics and X-Ray Crystallography of Correct and Incorrect Pairing.
J.Biol.Chem., 282, 2007

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