PDB: 46006 件ウェブページステータス検索Chemie searchBIRD

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1KHU	Smad1 crystal structure reveals the details of BMP signaling pathway 分子名称: SMAD1 著者 Qin, B.Y, Lin, K. 登録日 2001-12-01 公開日 2001-12-12 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis of Smad1 activation by receptor kinase phosphorylation. Mol.Cell, 8, 2001
7N03	Crystal structure of MTH1 in complex with compound 31 分子名称: 4-anilino-6-(hexylamino)-N-methylquinoline-3-carboxamide, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION 著者 Eron, S.J. 登録日 2021-05-24 公開日 2021-11-03 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.13 Å) 主引用文献 Development of an AchillesTAG degradation system and its application to control CAR-T activity Curr Res Chem Biol, 1, 2021
1KHW	Crystal Structure of Rabbit Hemorrhagic Disease Virus RNA-dependent RNA polymerase complexed with Mn2+ 分子名称: MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE 著者 Ng, K.K, Cherney, M.M, Vazquez, A.L, Machin, A, Alonso, J.M, Parra, F, James, M.N. 登録日 2001-12-01 公開日 2002-01-16 最終更新日 2019-07-24 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structures of active and inactive conformations of a caliciviral RNA-dependent RNA polymerase. J.Biol.Chem., 277, 2002
7N13	Crystal structure of MTH1 in complex with compound 32 分子名称: 4-anilino-6-[4-(butylcarbamoyl)-3-fluorophenyl]-N-cyclopropyl-7-fluoroquinoline-3-carboxamide, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION 著者 Eron, S.J. 登録日 2021-05-26 公開日 2021-11-03 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Development of an AchillesTAG degradation system and its application to control CAR-T activity Curr Res Chem Biol, 1, 2021
3PJA	Crystal structure of human C3PO complex 分子名称: Translin, Translin-associated protein X 著者 Huang, N, Zhang, H. 登録日 2010-11-09 公開日 2011-05-11 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure of C3PO and mechanism of human RISC activation. Nat.Struct.Mol.Biol., 18, 2011
6GLT	Crystal structure of hMTH1 D120N in the presence of acetate 分子名称: 7,8-dihydro-8-oxoguanine triphosphatase, DIMETHYL SULFOXIDE 著者 Eberle, S.A, Wiedmer, L, Sledz, P, Caflisch, A. 登録日 2018-05-23 公開日 2019-02-20 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.596 Å) 主引用文献 in progress To Be Published
1KPE	PKCI-TRANSITION STATE ANALOG 分子名称: ADENOSINE-5'-DITUNGSTATE, PROTEIN KINASE C INTERACTING PROTEIN 著者 Lima, C.D, Klein, M.G, Hendrickson, W.A. 登録日 1997-09-25 公開日 1998-03-25 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure-based analysis of catalysis and substrate definition in the HIT protein family. Science, 278, 1997
6V6L	Co-structure of human glycogen synthase kinase beta with 1-(6-((2-((6-amino-5-nitropyridin-2-yl)amino)ethyl)amino)-2-(2,4-dichlorophenyl)pyridin-3-yl)-4-methylpiperazin-2-one 分子名称: 1-(6-((2-((6-amino-5-nitropyridin-2-yl)amino)ethyl)amino)-2-(2,4-dichlorophenyl)pyridin-3-yl)-4-methylpiperazin-2-one, Glycogen synthase kinase-3 beta, PHOSPHATE ION 著者 Bussiere, D.E, Fang, E, Shu, W. 登録日 2019-12-05 公開日 2020-01-15 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 Discovery and optimization of novel pyridines as highly potent and selective glycogen synthase kinase 3 inhibitors. Bioorg.Med.Chem.Lett., 30, 2020
5T0Z	PelC from Geobacter metallireducens 分子名称: Lipoprotein, putative 著者 Marmont, L.S, Howell, P.L. 登録日 2016-08-17 公開日 2017-03-15 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.255 Å) 主引用文献 Oligomeric lipoprotein PelC guides Pel polysaccharide export across the outer membrane of Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
1CTL	STRUCTURE OF THE CARBOXY-TERMINAL LIM DOMAIN FROM THE CYSTEINE RICH PROTEIN CRP 分子名称: AVIAN CYSTEINE RICH PROTEIN, ZINC ION 著者 Perez-Alvarado, G.C, Miles, C, Michelsen, J.W, Louis, H.A, Winge, D.R, Beckerle, M.C, Summers, M.F. 登録日 1995-01-06 公開日 1995-06-03 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Structure of the carboxy-terminal LIM domain from the cysteine rich protein CRP. Nat.Struct.Biol., 1, 1994
5H66	Crystal structure of the Bacillus subtilis SMC head domain complexed with the cognate ScpA C-terminal domain 分子名称: Chromosome partition protein Smc, Segregation and condensation protein A 著者 Kamada, K, Hirano, T. 登録日 2016-11-11 公開日 2017-03-15 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.82194769 Å) 主引用文献 Overall Shapes of the SMC-ScpAB Complex Are Determined by Balance between Constraint and Relaxation of Its Structural Parts Structure, 25, 2017
5TLU	Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the PEG-linked Dimeric Estrogen, EE2-(eg)6-EE2-amine 分子名称: (14beta,17alpha)-21-(4-aminophenyl)-19-norpregna-1(10),2,4-trien-20-yne-3,17-diol, Estrogen receptor, NUCLEAR RECEPTOR COACTIVATOR 2 著者 Nwachukwu, J.C, Srinivasan, S, Bruno, N.E, Nowak, J, Kojetin, D.J, Elemento, O, Katzenellenbogen, J.A, Nettles, K.W. 登録日 2016-10-12 公開日 2017-01-18 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.223 Å) 主引用文献 Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24, 2017
5TM3	Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with 2,3-bis(2-chloro-4-hydroxyphenyl)thiophene 1-oxide 分子名称: (1S)-2,3-bis(2-chloro-4-hydroxyphenyl)-1H-1lambda~4~-thiophen-1-one, Estrogen receptor, Nuclear receptor coactivator 2 著者 Nwachukwu, J.C, Erumbi, R, Srinivasan, S, Bruno, N.E, Nowak, J, Izard, T, Kojetin, D.J, Elemento, O, Katzenellenbogen, J.A, Nettles, K.W. 登録日 2016-10-12 公開日 2017-01-18 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.194 Å) 主引用文献 Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24, 2017
5TML	Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the OBHS-ASC compound, (E)-6-(4-((1R,4S,6R)-6-((3-chlorophenoxy)sulfonyl)-3-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-2-en-2-yl)phenyl)hex-5-enoic acid 分子名称: 6-{4-[(1S,4S,6R)-6-[(3-chlorophenoxy)sulfonyl]-3-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-2-en-2-yl]phenyl}hex-5-enoic acid, Estrogen receptor, Nuclear receptor coactivator 2 著者 Nwachukwu, J.C, Erumbi, R, Srinivasan, S, Bruno, N.E, Nowak, J, Izard, T, Kojetin, D.J, Elemento, O, Katzenellenbogen, J.A, Nettles, K.W. 登録日 2016-10-13 公開日 2017-01-18 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24, 2017
5T5X	High resolution structure of mouse Cryptochrome 1 分子名称: CHLORIDE ION, Cryptochrome-1 著者 Michael, A.K, Tripathi, S, Partch, C.L. 登録日 2016-08-31 公開日 2017-02-08 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Formation of a repressive complex in the mammalian circadian clock is mediated by the secondary pocket of CRY1. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5THS	Crystal Structure of G302A HDAC8 in complex with M344 分子名称: 1,2-ETHANEDIOL, 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, Histone deacetylase 8, ... 著者 Porter, N.J, Christianson, D.W. 登録日 2016-09-30 公開日 2016-12-21 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural and Functional Influence of the Glycine-Rich Loop G302GGGY on the Catalytic Tyrosine of Histone Deacetylase 8. Biochemistry, 55, 2016
5TII	Comprehensive Analysis of a Novel Ketoreductase for Pentangular Polyphenol Biosynthesis 分子名称: 3-oxoacyl-ACP reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Valentic, T.R, Tsai, S.C, Brady, S.F. 登録日 2016-10-03 公開日 2016-11-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Comprehensive Analysis of a Novel Ketoreductase for Pentangular Polyphenol Biosynthesis. ACS Chem. Biol., 11, 2016
3GOO	Strontium bound to the Holliday junction sequence d(TCGGCGCCGA)4 分子名称: 5'-D(*TP*CP*GP*GP*CP*GP*CP*CP*GP*A)-3', STRONTIUM ION 著者 Naseer, A, Cardin, C.J. 登録日 2009-03-19 公開日 2009-04-07 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Strontium bound to the Holliday junction sequence d(TCGGCGCCGA)4 To be Published
5HLN	X-RAY CRYSTAL STRUCTURE OF GSK3B IN COMPLEX WITH CHIR99021 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHIR99021, Glycogen synthase kinase-3 beta, ... 著者 White, A, Lakshminarasimhan, D, Nadupalli, A, Suto, R.K. 登録日 2016-01-15 公開日 2016-05-25 最終更新日 2016-07-27 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects. Acs Chem.Biol., 11, 2016
5TLO	Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with a Squaric Acid-linked Dimeric Estrogen 分子名称: (14beta,17alpha)-21-(4-aminophenyl)-19-norpregna-1(10),2,4-trien-20-yne-3,17-diol, Estrogen receptor, NUCLEAR RECEPTOR COACTIVATOR 2 著者 Nwachukwu, J.C, Srinivasan, S, Bruno, N.E, Nowak, J, Kojetin, D.J, Elemento, O, Katzenellenbogen, J.A, Nettles, K.W. 登録日 2016-10-11 公開日 2017-01-18 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24, 2017
4PL6	Structure of the chromodomain of MRG2 in complex with H3K4me3 分子名称: At1g02740, H3K4me3 著者 Liu, Y.C, Huang, Y. 登録日 2014-05-16 公開日 2015-07-22 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.681 Å) 主引用文献 Regulation of arabidopsis flowering by the histone mark readers MRG1/2 via interaction with CONSTANS to modulate FT expression. Plos Genet., 10, 2014
5UKJ	The co-structure of N,N-dimethyl-4-[(6R)-6-methyl-5-(1H-pyrrolo[2,3- b]pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5- a]pyrazin-3-yl]benzenesulfonamide and a rationally designed PI3K-alpha mutant that mimics ATR 分子名称: N,N-dimethyl-4-[(6R)-6-methyl-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl]benzenesulfonamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 著者 Knapp, M.S, Elling, R.A, Mamo, M. 登録日 2017-01-23 公開日 2017-05-10 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Rationally Designed PI3K alpha Mutants to Mimic ATR and Their Use to Understand Binding Specificity of ATR Inhibitors. J. Mol. Biol., 429, 2017
6VNW	Cryo-EM structure of apo-BBSome 分子名称: BBS1 domain-containing protein, Bardet-Biedl syndrome 18 protein, Bardet-Biedl syndrome 2 protein homolog, ... 著者 Yang, S, Walz, T, Nachury, M, Chou, H. 登録日 2020-01-29 公開日 2020-07-01 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.44 Å) 主引用文献 Near-atomic structures of the BBSome reveal the basis for BBSome activation and binding to GPCR cargoes. Elife, 9, 2020
7MFF	Dimeric (BRAF)2:(14-3-3)2 complex bound to SB590885 Inhibitor 分子名称: (1Z)-5-(2-{4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL}-5-PYRIDIN-4-YL-1H-IMIDAZOL-4-YL)INDAN-1-ONE OXIME, 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf 著者 Martinez Fiesco, J.A, Ping, Z, Durrant, D.E, Morrison, D.K. 登録日 2021-04-09 公開日 2022-01-26 最終更新日 2022-02-09 実験手法 ELECTRON MICROSCOPY (3.89 Å) 主引用文献 Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding. Nat Commun, 13, 2022
8K81	Solution NMR Structure of ZF3 (fragment 346-396) from human Insulinoma-associated protein 1(INSM1) 分子名称: Insulinoma-associated protein 1, ZINC ION 著者 He, X.L, Yang, Y.H. 登録日 2023-07-28 公開日 2024-07-31 実験手法 SOLUTION NMR 主引用文献 Solution NMR Structure of ZF3 (fragment 346-396) from human Insulinoma-associated protein 1(INSM1) To Be Published

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