7N13

Crystal structure of MTH1 in complex with compound 32

Summary for 7N13

• Entry DOI: 10.2210/pdb7n13/pdb
• Related: 7N03
• Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, 4-anilino-6-[4-(butylcarbamoyl)-3-fluorophenyl]-N-cyclopropyl-7-fluoroquinoline-3-carboxamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 37836.69

Authors

Eron, S.J. (deposition date: 2021-05-26, release date: 2021-11-03, Last modification date: 2023-10-18)

• Primary citation: Veits, G.K.,Henderson, C.S.,Vogelaar, A.,Eron, S.J.,Lee, L.,Hart, A.,Deibler, R.W.,Baddour, J.,Elam, W.A.,Agafonov, R.V.,Freda, J.,Chaturvedi, P.,Ladd, B.,Carlson, M.W.,Vora, H.U.,Scott, T.G.,Tieu, T.,Jain, A.,Chen, C.L.,Kibbler, E.S.,Pop, M.S.,He, M.,Kern, G.,Maple, H.J.,Marsh, G.P.,Norley, M.C.,Oakes, C.S.,Henderson, J.A.,Sowa, M.E.,Phillips, A.J.,Proia, D.A.,Park, E.S.,Patel, J.S.,Fisher, S.L.,Nasveschuk, C.G.,Zeid, R.; Development of an AchillesTAG degradation system and its application to control CAR-T activity; Curr Res Chem Biol, 1:100010-, 2021; DOI: 10.1016/j.crchbi.2021.100010

Experimental method

X-RAY DIFFRACTION (1.59 Å)