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7KDJ
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SARS-CoV-2 D614G 1-RBD-up Spike Protein Trimer fully cleaved by furin without the P986-P987 stabilizing mutations (S-RRAR-D614G)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Gobeil, S, Acharya, P.
登録日2020-10-08
公開日2020-11-04
最終更新日2021-03-31
実験手法ELECTRON MICROSCOPY (3.49 Å)
主引用文献D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction.
Cell Rep, 34, 2021
7JFN
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Crystal Structure of Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein from Brucella ovis, closed conformation
分子名称: 1,2-ETHANEDIOL, NITRATE ION, POTASSIUM ION, ...
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2020-07-17
公開日2020-07-29
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal Structure of Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein from Brucella ovis, closed conformation
to be published
7JJF
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Sarcin-ricin loop with modified residue.
分子名称: MAGNESIUM ION, RNA/DNA (27-mer)
著者Harp, J.M, Pallan, P.S, Egli, M.
登録日2020-07-25
公開日2020-12-23
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Incorporating a Thiophosphate Modification into a Common RNA Tetraloop Motif Causes an Unanticipated Stability Boost.
Biochemistry, 59, 2020
7JJU
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Crystal structure of en exoribonuclease-resistant RNA (xrRNA) from Potato leafroll virus (PLRV)
分子名称: CACODYLATE ION, Guanidinium, IRIDIUM HEXAMMINE ION, ...
著者Steckelberg, A.-L, Vicens, Q, Auffinger, P, Costantino, D.C, Nix, J.C, Kieft, J.S.
登録日2020-07-27
公開日2020-09-09
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.604 Å)
主引用文献The crystal structure of a Polerovirus exoribonuclease-resistant RNA shows how diverse sequences are integrated into a conserved fold.
Rna, 26, 2020
7JKC
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Sheep Connexin-46 at 1.9 angstroms resolution by CryoEM
分子名称: 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, Gap junction alpha-3 protein
著者Flores, J.A, Haddad, B.G, Dolan, K.D, Myers, J.B, Yoshioka, C.C, Copperman, J, Zuckerman, D.M, Reichow, S.L.
登録日2020-07-28
公開日2020-09-09
最終更新日2024-10-16
実験手法ELECTRON MICROSCOPY (1.9 Å)
主引用文献Connexin-46/50 in a dynamic lipid environment resolved by CryoEM at 1.9 angstrom.
Nat Commun, 11, 2020
7K6E
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SARS-CoV-2 Main Protease Co-Crystal Structure with Telaprevir Determined from Crystals Grown with 40 nL Acoustically Ejected Mpro Droplets at 1.63 A Resolution (Direct Vitrification)
分子名称: (1S,3aR,6aS)-2-[(2S)-2-({(2S)-2-cyclohexyl-2-[(pyrazin-2-ylcarbonyl)amino]acetyl}amino)-3,3-dimethylbutanoyl]-N-[(2R,3S)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl]octahydrocyclopenta[c]pyrrole-1-carboxamide, 3C-like proteinase, DIMETHYL SULFOXIDE
著者Kreitler, D.F, Andi, B, Kumaran, D, Soares, A.S, Shi, W, Jakoncic, J, Fuchs, M.R, Keereetaweep, J, Shanklin, J, McSweeney, S.
登録日2020-09-19
公開日2020-09-30
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Hepatitis C virus NS3/4A inhibitors and other drug-like compounds as covalent binders of SARS-CoV-2 main protease.
Sci Rep, 12, 2022
8WIL
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BU of 8wil by Molmil
Crystal structure of Jingmen tick virus RNA-dependent RNA polymerase (D55 construct)
分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, Jingmen tick virus NSP1, ...
著者Wang, X, Jing, X, Deng, F, Gong, P.
登録日2023-09-24
公開日2024-01-17
最終更新日2024-04-24
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A jingmenvirus RNA-dependent RNA polymerase structurally resembles the flavivirus counterpart but with different features at the initiation phase.
Nucleic Acids Res., 52, 2024
7K84
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Crystal structure of BoNT/E LC-HN domain in complex with VHH JLE-E5
分子名称: Botulinum neurotoxin type E, JLE-E5, SULFATE ION, ...
著者Lam, K, Jin, R.
登録日2020-09-25
公開日2020-10-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Two VHH Antibodies Neutralize Botulinum Neurotoxin E1 by Blocking Its Membrane Translocation in Host Cells.
Toxins, 12, 2020
7KDK
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SARS-CoV-2 D614G 3 RBD down Spike Protein Trimer without the P986-P987 stabilizing mutations (S-GSAS-D614G)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Gobeil, S, Acharya, P.
登録日2020-10-08
公開日2020-11-04
最終更新日2021-03-31
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction.
Cell Rep, 34, 2021
7K3L
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BU of 7k3l by Molmil
Crystal structure of dLC8 in complex with Panoramix TQ peptide
分子名称: 1,2-ETHANEDIOL, Dynein light chain 1, cytoplasmic, ...
著者Wang, J, Patel, D.J.
登録日2020-09-11
公開日2021-03-03
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Molecular principles of Piwi-mediated cotranscriptional silencing through the dimeric SFiNX complex.
Genes Dev., 35, 2021
7JTG
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BU of 7jtg by Molmil
Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody RM11-43
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein E2, ...
著者Tzarum, N, Wilson, I.A, Law, M.
登録日2020-08-17
公開日2021-03-10
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献HCV Env immunization elicits a rapid VH1-69-like broadly neutralizing antibody response in rhesus macaques
Immunity, 2021
7JTF
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Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody RM2-01
分子名称: Envelope glycoprotein E2, RM2-01 Fab heavy chain, RM2-01 Fab light chain
著者Tzarum, N, Wilson, I.A, Law, M.
登録日2020-08-17
公開日2021-03-10
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.35 Å)
主引用文献HCV Env immunization elicits a rapid VH1-69-like broadly neutralizing antibody response in rhesus macaques
Immunity, 2021
7K62
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BU of 7k62 by Molmil
Crystal Structure of Dihydrofolate reductase from Mycobacterium kansasii in complex with NADP and inhibitor P218
分子名称: 1,2-ETHANEDIOL, 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, Dihydrofolate reductase, ...
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2020-09-18
公開日2021-03-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Crystal Structure of Dihydrofolate reductase from Mycobacterium kansasii in complex with NADP and inhibitor P218
To Be Published
7K65
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Hedgehog receptor Patched (PTCH1) in complex with conformation selective nanobody TI23
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside, ...
著者Zhang, Y, Bulkley, D.P, Liang, J, Manglik, A, Cheng, Y, Beachy, P.A.
登録日2020-09-18
公開日2021-03-17
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit.
Proc.Natl.Acad.Sci.USA, 117, 2020
7KDV
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BU of 7kdv by Molmil
Murine core lysosomal multienzyme complex (LMC) composed of acid beta-galactosidase (GLB1) and protective protein cathepsin A (PPCA, CTSA)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-galactosidase, ...
著者Gorelik, A, Illes, K, Hasan, S.M.N, Nagar, B, Mazhab-Jafari, M.T.
登録日2020-10-09
公開日2021-03-17
最終更新日2021-05-26
実験手法ELECTRON MICROSCOPY (4.59 Å)
主引用文献Structure of the murine lysosomal multienzyme complex core.
Sci Adv, 7, 2021
7K6A
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BU of 7k6a by Molmil
Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001575
分子名称: 1,2-ETHANEDIOL, 6-ethyl-5-[3-({3-[4-(trifluoromethyl)piperidin-1-yl]pyridin-2-yl}oxy)propoxy]pyrimidine-2,4-diamine, CHLORIDE ION, ...
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2020-09-19
公開日2021-03-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001575
to be published
7KDD
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BU of 7kdd by Molmil
HCMV postfusion gB in complex with SM5-1 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Envelope glycoprotein B, ...
著者Liu, Y, Heim, P.K, Che, Y, Chi, X, Qiu, X, Han, S, Dormitzer, P.R, Yang, X.
登録日2020-10-08
公開日2021-03-17
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Prefusion structure of human cytomegalovirus glycoprotein B and structural basis for membrane fusion.
Sci Adv, 7, 2021
7K69
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BU of 7k69 by Molmil
Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001574
分子名称: 1-{2-[2-(2,4-diamino-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)-2-oxoethoxy]phenyl}piperidine-4-carboxylic acid, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2020-09-19
公開日2021-03-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001574
To Be Published
7JTZ
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BU of 7jtz by Molmil
Yeast Glo3 GAP domain
分子名称: ADP-ribosylation factor GTPase-activating protein GLO3, GLYCEROL, ZINC ION
著者Xie, B, Jackson, L.P.
登録日2020-08-18
公開日2021-03-24
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献The Glo3 GAP crystal structure supports the molecular niche model for ArfGAPs in COPI coats.
Adv Biol Regul, 79, 2021
7K68
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Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001565
分子名称: 3-(3-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, CHLORIDE ION, Dihydrofolate reductase, ...
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2020-09-19
公開日2021-03-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001565
To Be Published
7K0X
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BU of 7k0x by Molmil
Marsupial T cell receptor Spl_145
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, T cell receptor gamma chain, T cell receptor mu chain, ...
著者Wegrecki, M, Kannan Sivaraman, K, Le Nours, J, Rossjohn, J.
登録日2020-09-06
公開日2021-03-24
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献The molecular assembly of the marsupial gamma mu T cell receptor defines a third T cell lineage.
Science, 371, 2021
7JO7
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BU of 7jo7 by Molmil
Crystal Structure of Human Scribble PDZ2
分子名称: 1,2-ETHANEDIOL, Protein scribble homolog
著者How, J.Y, Kvansakul, M.
登録日2020-08-06
公開日2021-03-24
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.44 Å)
主引用文献Structural basis of the human Scribble-Vangl2 association in health and disease.
Biochem.J., 478, 2021
7K0Z
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Marsupial T cell receptor Spl_157
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, T cell receptor gamma chain, T cell receptor mu chain
著者Wegrecki, M, Kannan Sivaraman, K, Le Nours, J, Rossjohn, J.
登録日2020-09-06
公開日2021-03-24
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献The molecular assembly of the marsupial gamma mu T cell receptor defines a third T cell lineage.
Science, 371, 2021
7KC2
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BU of 7kc2 by Molmil
Symmetry in Yeast Alcohol Dehydrogenase 1 -Closed Form with NADH
分子名称: Alcohol dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ZINC ION
著者Subramanian, R, Chang, L, Li, Z, Plapp, B.V.
登録日2020-10-04
公開日2021-03-31
最終更新日2024-09-04
実験手法ELECTRON MICROSCOPY (2.67 Å)
主引用文献Cryo-Electron Microscopy Structures of Yeast Alcohol Dehydrogenase.
Biochemistry, 60, 2021
7JLN
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BU of 7jln by Molmil
Crystal structure of glVRC01 Fab in complex with anti-idiotype iv9 Fab
分子名称: AMMONIUM ION, SODIUM ION, glVRC01 Heavy Chain, ...
著者Weidle, C, Pancera, M.
登録日2020-07-30
公開日2021-03-31
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.57 Å)
主引用文献Development of a VRC01-class germline targeting immunogen derived from anti-idiotypic antibodies.
Cell Rep, 35, 2021

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