7K68
Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001565
Summary for 7K68
Entry DOI | 10.2210/pdb7k68/pdb |
Descriptor | Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-(3-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, ... (5 entities in total) |
Functional Keywords | ssgcid, sddc, inhibitor, structural genomics, seattle structural genomics center for infectious disease, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Mycobacterium ulcerans (strain Agy99) |
Total number of polymer chains | 1 |
Total formula weight | 20190.95 |
Authors | Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2020-09-19, release date: 2021-03-17, Last modification date: 2023-10-18) |
Primary citation | Abendroth, J.,Dranow, D.M.,Santhakumar, V.,Walpole, C.,Lorimer, D.D.,Horanyi, P.S.,Edwards, T.E. Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001565 To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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