7K6A
Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001575
Summary for 7K6A
Entry DOI | 10.2210/pdb7k6a/pdb |
Descriptor | Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-ethyl-5-[3-({3-[4-(trifluoromethyl)piperidin-1-yl]pyridin-2-yl}oxy)propoxy]pyrimidine-2,4-diamine, ... (6 entities in total) |
Functional Keywords | ssgcid, sddc, inhibitor, structural genomics, seattle structural genomics center for infectious disease, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Mycobacterium ulcerans (strain Agy99) |
Total number of polymer chains | 1 |
Total formula weight | 20457.21 |
Authors | Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2020-09-19, release date: 2021-03-17, Last modification date: 2023-10-18) |
Primary citation | Abendroth, J.,Dranow, D.M.,Santhakumar, V.,Walpole, C.,Lorimer, D.D.,Horanyi, P.S.,Edwards, T.E. Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001575 to be published, |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
Download full validation report